Jesse McLean
MSc, PhD
Completed PhD 2009
The decision to study neurodegenerative diseases at the PhD level was an exciting step forward for me. When choosing a graduate department, I recognized that my success would hinge upon exposure to cutting-edge research facilities and strong collaborations with passionate colleagues. Consequently, I was drawn to the breadth and depth of research performed within LMP, a department which brings together many elements of the research and medical communities in Toronto. I discovered that the extensive collaborations among LMP faculty, staff, and students, each with diverse research backgrounds, fostered innovative scientific discovery that was unparalleled among graduate programs in Canada. During my training, I had the opportunity to network with both faculty and alumni through courses, seminars, conferences, teaching appointments, and social events and these experiences ultimately helped me define my own individual path. My graduate studies with LMP prepared me for an exciting postdoctoral fellowship in translational neuroscience with Prof. Ole Isacson at Harvard Medical School. After four years, I am thrilled to be back working once again with LMP researchers in the hopes of using my postdoctoral knowledge and skills to find new therapies for neurodegenerative diseases.
Current Position: 
James Hunter and Family ALS Research Fellow, Tanz CRND
Research Focus: 

My current research focuses on developing stem cell and viral gene therapies for understanding and treating neurodegenerative diseases, with an emphasis on amyotrophic lateral sclerosis and Parkinson’s disease. I use CRISPR/Cas9 technology and patient-derived induced pluripotent stem cells to identify the molecular and cellular correlates of disease and to translate these findings into novel in vitro and in vivo therapeutic models.