My work concentrates on the study of biomarkers in endocrine tumors and their role as prognostic and diagnostic markers.
My research program is based on the translation of basic findings to clinical tests for endocrine diseases. My work concentrates on the study of biomarkers in endocrine tumors and their role as prognostic and diagnostic markers. We have constructed tissue microarrays of several types of endocrine tumors; we analyse novel immunohistochemical and FISH probes. In collaboration with other members of the Endocrine Oncology Group at PMH/OCI, I also am involved in the analysis of mouse models of endocrine neoplasia.
An additional area of interest involves the application of Digital Analysis in Anatomical Pathology. I am carrying out a study of Computer-Assisted Diagnostics (CAD) in thyroid tumors and have assisted in a similar study of prostate carcinomas. This work will have significant impact for the practice of pathology in the future as we validate the applications of image analysis and neural networks in tissue pathology.
Mete O, Asa SL. Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation. Mod Pathol. 2011 Dec;24(12):1545-52.
Mete O, Ezzat S, Asa SL. Biomarkers of aggressive pituitary adenomas. J Mol Endocrinol. 2012; 49, R1-R11. PubMed PMID: 22822048.
Mete O, Rotstein L, Asa SL. Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension. Ann Surg Oncol. 2010 Feb;17(2):386-91.
Mete O, Asa SL. Oncocytes, oxyphils, Hürthle, and Askanazy cells: morphological and molecular features of oncocytic thyroid nodules. Endocr Pathol. 2010 Mar;21(1):16-24.
Mete O, Kapran Y, Güllüoğlu MG, Kiliçaslan I, Erbil Y, Senyürek YG, Dizdaroğlu F. Anti-CD10 (56C6) is expressed variably in adrenocortical tumors and cannot be used to discriminate clear cell renal cell carcinomas. Virchows Arch. 2010 May;456(5):515-21.
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