Research location: University of Toronto - St. George Campus (downtown)
Primary Research Area: Molecular & Cell Biology
Secondary Research Area: Cardiovascular
We study the role of calreticulin, a ubiquitous calcium-binding chaperone of the ER/SR, which affects calcium homeostasis and gene expression, in ES cell choice of fate. We discovered that calreticulin acts as a switch either promoting (bone) or suppressing (fat) stem cell differentiation, while it seems to deregulate cardiogenesis.