Brain & Neuroscience researchers study neuropyschology, neuroimmunology, neurogenetics, proteomics and neurological disease mechanisms. The goal of these investigations, and the study of their respective pathobiological networks, is to better understand and treat neurodegenerative diseases such as Alzheimer’s, brain cancer and, in general, all diseases related to the brain and nervous system.
Our broad spectrum of research includes:
- the role of ion channels
- receptors and signal transduction
- synapse formation and plasticity
- neural cell fate
- neuronal guidance
- neuronal networks
Faculty Involved in Brain & Neuroscience Research
As a devoted electron microscopist, I am interested in the utilization of advanced EM methodologies in the study of disease. These include analytical energy dispersive x-ray spectrometry, cryomicroscopy, immunogold labelling, morphometry and electron tomography. As a consequence I have been able to identify changes in diseases I have been studying that might not have been detected using conventional approaches.
The Brain Repair Group, led by Dr. Isabelle Aubert, focuses on developing therapies to stop neurodegeneration and promote regeneration under pathological conditions found in cases of Alzheimer's disease.
My research program is aimed at understanding myelinogenesis by oligodendrocytes. We are currently focusing on the structure and roles of myelin basic protein in interactions with the cytoskeleton and SH3-domain proteins and the role of glycosphingolipids in cell-surface phenomena. We are also studying the effect of estrogens on oligodendrocytes and myelin.
Our team focuses on the mechanisms and potential treatments of blinding eye disease. We take a fully integrated translational approach that includes pre-clinical models of disease, biomarker development, and early and late phase clinical trial.
My research focuses on two areas: (1) clinical utility of biomarkers (proteins & DNA) in lymphoproliferative and cerebrovascular diseases, and (2) practice-based research;
Our research program focuses on discovering and elucidating the molecular signaling pathways and transcription factors responsible for the development of the mechanosensory hair cells - cells that detect sound, and auditory neurons - cells that transmit sound information from the hair cells to the brain, in the mammalian inner ear.
Our lab is interested in the mechanisms that underlie the stem cell identity and direct cell fate in the normal brain and in glioblastoma.
Leveraging clinical neuropathology expertise and resources to develop novel approaches to the understanding of neurological diseases
Retinal disease, glaucoma, degeneration of vision pathways, neuroprotection and pharmacological treatment strategies, intraocular pressure regulation, the role of the lymphatic circulation in the eye, neuroimaging and clinical trials, public health
Dr. Halliday is a clinically oriented Neuropathologist with a longstanding interest in correlative studies, particularly clinical-pathological and radiological-pathological correlations. Expertise with morphological investigations is shared with collaborative research studies, especially in the area of oncology (retinoblastoma). Central nervous system traumatic injury, particularly as it relates to infants, is an ongoing interest.
Molecular mechanisms underlying long term effects of brain trauma, Chronic Traumatic Encephalopathy and Seizure disorder.
My areas of research include development of experimental models in forensic pathology and public health.
My research aims to understand the key molecular pathways responsible for neurodegeneration in Parkinson's disease and to develop novel therapies by targetting these pathways.
My laboratory focuses on understanding how chaperone molecules fail to maintain protein homeostasis in Parkinson's disease and other neurodegenerative disorders with the goal of developing novel molecular therapeutics for the treatment of these disorders.
Mechanisum as to how Ethanol does organ damage; Folate in women of child bearing age; Pharmacokinetis of drugs in the opiate dependent patient.
My academic interests include education, neuromuscular and neurodegenerative neuropathology.
Study of pituitary tumours using histology, immunohistochemistry, electron microscopy and, in collaboration, applying molecular/genetic methods. Tumour morphology is correlated with clinical findings, endocrinologic and imaging parameters. Investigations include: biomarkers, angiogenesis, biologic behaviour, prediction of prognosis and assessment of therapeutic responsiveness.
My research focuses on development of therapeutics to target protein-misfolding disorders, in particular Alzheimer’s disease. Stemming from the basic research of protein-lipid interactions, we identified a family of compounds that inhibit the formation of toxic soluble aggregates in Alzheimer’s disease that has added to our understanding of disease progression and human clinical trials.
His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer's disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis.He also publishes regularly on neuro-oncology and diagnostic aspects of general neuropathology.
The focus of our research is to study the cause(s) and cure(s ) of Amyotrophic Lateral Scelrosis.
My lab studies the molecular biology of human brain tumours. We have developed model systems to analyze the manner in which brain tumours grow, invade, and evade therapy. Our goal is to increase our understanding of brain tumour biology so that new treatments can be discovered in the lab.
Our work contributes to two strands of investigations at the interface of proteomics and neurodegenerative disease research: the development of strategies for the study of protein interactions and the application of these strategies to address questions in the context of neurodegenerative disease research.
Dr Shek's research addresses severe hemorrhage associated with coagulopathy that requires immediate blood loss control and fluid resuscitation. His other research area explores the application of magnetoencephalography for the objective diagnosis and assessment of post traumatic stress disorder (PTSD) and mild traumatic brain injury.
Our laboratory is investigating the molecular pathways directing tissue injury and repair responses in the eye. Current projects are investigating damage to the inner retina and optic nerve, associated with development of glaucoma, a leading cause of vision loss and blindness.
Research is focused on the identification and characterization of genetic conditions in psychiatric patients, particularly those with dual diagnosis (psychiatric disorder + intellectual disability). In collaboration with psychiatrists, the goal is to develop protocols and tools for psychiatrists and primary care physicians to optimize the diagnosis, management and treatment of psychiatric patients with underlying genetic disorders.
We use advanced genomic technologies to identify novel genetic variants responsible for neurodevelopmental disorders, with the ultimate goal of understanding the downstream biological pathways.
We use functional genomic and epigenomic tools to investigate how normal cells are turned into brain tumours. In addition, we use the genomic analyses results to create new animal models of medulloblastoma and ependymoma so that novel targeted therapies can be developed. This multi-layered approach allows for rapid clinically-important changes to brain tumour therapy, such that the quality of life of patients can be drastically improved.
My main interest is in Therapeutic Drug Monitoring (TDM) and Clinical Toxicology. Also interested in Genetic Metabolic Disease, (small molecule disease). Interested in detection of drugs in overdose cases by chromatographic and immunoassay methods for clinical applications. Quantitation of Immunosuppressives in blood for TDM. Development and evaluation of new methods for drug analysis.
The Wallace lab is working on the regulation of neurogenesis and neural progenitor transformation in the vertebrate CNS and regenrative medicine approaches to retina repair.
Current research interest in genetics and pharmacogenetics of neuropsychiatric disorders and suicidal behaviour. Secondary interests include rodent behavioural models and whole-genome study methods.