Special Seminar: Elaborate “eukaryotic-like” mechanisms for immune nuclease avoidance by a jumbo bacteriophage
Join us for a special Tenure-track professorship and CERC candidate seminar hosted by the Department of Laboratory Medicine and Pathobiology and the Department of Biochemistry at the University of Toronto.
Dr. Joseph Bondy-Denomy, PhD
Professor and Vice Chair
Department of Microbiology and Immunology
University of California, San Francisco
Title: “Elaborate “eukaryotic-like” mechanisms for immune nuclease avoidance by a jumbo bacteriophage”
Where and when
Monday, September 15, 2025
11 am – 12 pm
In person, Donnelly Centre, Red Room
No registration required, all are welcome.
Terrence Donnelly Centre for Cellular & Biomolecular Research
160 College St, Toronto, ON M5S 3E1
About the speaker: Dr. Joseph Bondy-Denomy
Dr. Joseph Bondy-Denomy is a Professor in the Department of Microbiology & Immunology at the University of California, San Francisco.
The Bondy-Denomy lab is broadly interested in understanding mechanisms of CRISPR-Cas evasion by bacteriophages, including “phage nucleus” compartments, anti-CRISPR enzymes, and phage base modifications. The lab also works extensively on the immunity and anti-immunity mechanisms of Gabija, restriction-modification, CBASS, Thoeris, Shango, and Jumbo phage killer defenses.
A long-term goal is to rationally identify causal barriers to phage success in clinical bacterial isolates and systematically engineer clinical phages to overcome those barriers.
Work in the Bondy-Denomy lab has been funded by the NIH, DARPA, the Searle Scholars Program, the Vallee Foundation, and the Innovative Genomics Institute.
Prior to coming to UCSF, Joe was a PhD student with Alan Davidson at the University of Toronto, where he studied CRISPR-Cas system and phage-encoded anti-CRISPR proteins.
