Special Seminar: Persistent HIV Reservoirs - Mechanisms of Immune Escape and Pathways to Clearance
Join us for a special Tenure-track professorship and CERC candidate seminar hosted by the Department of Laboratory Medicine and Pathobiology and the Department of Biochemistry at the University of Toronto.
Dr. Brad Jones, PhD
Associate Professor
Principal investigator, Weill Cornell Medicine
Talk title: “Persistent HIV Reservoirs: Mechanisms of Immune Escape and Pathways to Clearance”
Where and when
Wednesday, September 3, 2025
11:00 am – 12:00 pm
In person, Donnelly Centre, Red Room
No registration required, all are welcome.
Terrence Donnelly Centre for Cellular & Biomolecular Research
160 College St, Toronto, ON M5S 3E1
About the speaker: Dr. Brad Jones
Dr. Brad Jones is an Associate Professor of Immunology in Medicine at Weill Cornell Medicine, where his laboratory investigates how HIV reservoirs evade immune clearance and develops strategies to overcome this central barrier to cure.
Combining multi-omic profiling, advanced in vitro systems, and participant-derived xenograft (PDX) mouse models, his group has recently defined metabolic and oxidative stress states linked to cytotoxic T lymphocyte (CTL) resistance and established “authentic reservoir clones” from people on long-term therapy to map their immune vulnerability and resistance phenotypes. His team also contributes immunologic expertise to HIV cure-related clinical trials, including ACTG A5386, which is testing the IL-15 superagonist N-803 with broadly neutralizing antibodies as a latency-reversing and immune-enhancing intervention.
Dr. Jones leads and co-leads multiple NIH-funded HIV cure consortia, integrating mechanistic discovery, advanced modeling, and clinical translation to inform curative strategies for persistent viral infections.
