Bruce Youngson

Bruce Youngson MSc, MD, FRCP
Assistant Professor
Anatomic Pathology
Department of Laboratory Medicine & Pathobiology
Bruce Youngson
Contact Info
T: (416) 340-5573
F: (416) 340-5517
University Health Network (UHN): Princess Margaret Hospital
200 Elizabeth St.
Lab Medicine Program, 11E-227
Toronto, ON, M5G 2C4
Appointment Status Primary
Clinical Interests
Anatomic Pathology, Breast Pathology
Research Interests

Staff Pathologist Toronto General Hospital 1991-current.      

Fellowship in Breast Pathology
Dept. of Pathology, Memorial Sloan-Kettering Cancer Center,
1275 York Avenue, New York, New York, U.S.A. 10021.
Supervisor Dr. P.P. Rosen  July 1993-June 1994

Fellow of the Royal College of Physicians and Surgeons of Canada [FRCP(C)]
Division of Medicine, Laboratory Specialties, Anatomical Pathology
Registration Date: June 1991

Diplomate of the American Board of Pathology in Anatomic Pathology
Registration Date: June 1991

Residency in Anatomic Pathology
Dept. of Pathology, University of Toronto, Banting Institute,
100 College Street, Toronto, Ontario, Canada, M5G 1L5
Program Directors Drs. C. Smith & T. Colgan  July 1987 - June 1991

Rotating Internship
St. Michael’s Hospital, University of Toronto,
30 Bond Street, Toronto, Ontario, Canada,
June 1984 - July 1985

General Medical Licence, The College of Physicians and Surgeons of Ontario
Registration Date: June 1985

Licentiate of the Medical Council of Canada
Registration Date: June 1984  

MD - University of Toronto 1984
MSc Pharmacology - University of Toronto 1980
BSc Pharmacology - University of Toronto 1977


Research Synopsis

The research I am involved in is clinically oriented and concentrates on my area of surgical pathology expertise: breast pathology. My most recent work has concentrated on sentinel lymph nodes and breast carcinoma. Other ongoing research work includes the pathology of ductal carcinoma in situ and lobular neoplasia, and predictive biomarkers and breast carcinoma.

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Cawthorn T.R., Moreno J.C., Dharsee M, Tran-Thanh D., Ackloo S, Zhu P.H., Sardana G, Chen J., Kupchak P., Jacks L.M., Miller N.M., Youngson B.J., Iakovlev V., Guidos C.J., Vallis K.A., Evans K.R., McCready D., Leong W.L., Done S.J.  (2012).  Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival.   PLoS ONE 7(2): 1-11.   

Sadi A.L., Wang D.Y., Youngson B.J., Miller N., Boerner S., Done S., Leong W. (2011).  Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens.  BMC Cancer 11:253-261.

Wang, C., Iakovlev V.V., Wong V., Leung S., Warren K., Iakvlva G., Arneson N.C.R., Pintilie M., Miller N., Youngson B., McCready D.R., Done S.J.  (2009).  Genomic alterations in primary breast cancers compared with their sentinel and more distal lymph node metastases:  An aCGH study. Genes Chromosomes & Cancer 48:1091-1101.

Boileau J.F., Easson A., Escallon J.M., Leong W. L., Reedijk M., Youngson B.J., McCready D.R.  (2008). Sentinel lymph nodes in breast cancer: relevance of axillary level II nodes and optimal number of nodes that need to be removed.   Ann Surg Oncol 15 (6):1710-16.

Schiller D.E., Le L.W., Cho B.C., Youngson B.J., McCready D.R. (2008). Factors associated with negative margins of lumpectomy specimen: potential use in selecting patients for intraoperative radiotherapy.   Ann Surg Oncol 15 (3):833-42

McKenna A.M.,  Pintilie M., Youngson B., and Done S.J. (2007).  Quantification of the morphologic features of fibroepithelial tumors of the breast. Arch Pathol Lab Med. 131(10):1568-1573.

McCready D.R., Yong W.S.,  Ng A.K.T., Miller N., Done S., Youngson B. (2004) AJCC Breast Cancer Staging System and Sentinel Lymph Nodes - response to letter to the editor.  JCNI 96(21):1639-1640.

McCready D.R., Yong W.S., Ng A. K.T., Miller N., Done S., Youngson B.  (2004). Influence of the new AJCC Breast Cancer Staging System on Sentinel Lymph Node Positivity and False Negative Rates.  Journal National Cancer Institute 96(11):873-875.