Lili-Naz Hazrati
PhD, MD, FRCPC
Lili-Naz Hazrati MD, PhD, FRCPC, is a neuropathologist at the Hospital for Sick Children and a clinician scientist at the Sickkids Research Institute.
She obtained her PhD in neurobiology at Laval University followed by postdoctoral training at Yale University.
She completed her medical training at the University of Montreal and residency training in neuropathology at the University of Toronto.
Research Synopsis
Molecular mechanisms underlying long term effects of brain trauma, Chronic Traumatic Encephalopathy and Seizure disorder.
Selected Publications
Tartaglia MC, Hazrati LN, Davis KD, Green RE, Wennberg R, Mikulis D, Ezerins LJ, Keightley M, Tator C Chronic traumatic encephalopathy and other neurodegenerative proteinopathies. Front Hum Neurosci. 2014 Jan 31;8:30. doi: 10.3389/fnhum.2014.00030. eCollection 2014. PMID:24550810
Connolly BS, Hazrati LN, Lang AE Neuropathological findings in chorea-acanthocytosis: new insights into mechanisms underlying parkinsonism and seizures. Acta Neuropathol. 2014 Apr;127(4):613-5. doi: 10.1007/s00401-013-1241-3. Epub 2014 Jan 7. PMID: 24394886
Maheandiran M, Mylvaganam S, Wu C, El-Hayek Y, Sugumar S, Hazrati L, del Campo M, Giacca A, Zhang L, Carlen PL Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality. PLoS One. 2013 Dec 30;8(12):e83168. doi: 10.1371/journal.pone.0083168. eCollection 2013. PMID:24386156
Visanji NP, Marras C, Hazrati LN, Liu LW, Lang AE Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker. Mov Disord. 2014 Apr;29(4):444-50. doi: 10.1002/mds.25789. Epub 2013 Dec 26. PMID: 24375496
Visanji NP, Brooks PL, Hazrati LN, Lang AE.The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathol Commun. 2013 May 8;1(1):2. doi: 10.1186/2051-5960-1-2. PMID: 24252164
Wong JC, Hazrati LN. Parkinson's disease, parkinsonism, and traumatic brain injury. Crit Rev Clin Lab Sci. 2013 Jul-Oct;50(4-5):103-6. doi: 10.3109/10408363.2013.844678. PMID:24156652
Visanji NP, Collingwood JF, Finnegan ME, Tandon A, House E, Hazrati LN. Iron deficiency in parkinsonism: region-specific iron dysregulation in Parkinson's disease and multiple system atrophy. J Parkinsons Dis. 2013;3(4):523-37. doi: 10.3233/JPD-130197. PMID: 24113558
Florez CM, McGinn RJ, Lukankin V, Marwa I, Sugumar S, Dian J, Hazrati LN, Carlen PL, Zhang L, Valiante TA In Vitro Recordings of Human Neocortical Oscillations. Cereb Cortex. 2013 Sep 17. [Epub ahead of print] PMID: 24046077
Butcher NJ, Kiehl TR, Hazrati LN, Chow EW, Rogaeva E, Lang AE, Bassett AS. JAMA Neurol. 2013 Nov;70(11):1359-66. .PMID:24018986
Wong JC, O'Neill B, Hawkins CE, Kleinschmidt-DeMasters BK, Hazrati LN. Child Neurology: Pediatric seizures with hyaline astrocytic inclusions. Neurology. 2013 Jul 16;81(3):e14-6. doi: 10.1212/WNL.0b013e31829bfe54. No abstract available. PMID: 23858415
Thomason LA, Smithson LJ, Hazrati LN, McLaurin J, Kawaja MD Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15). FEBS Lett. 2013 Aug 2;587(15):2448-54. doi: 10.1016/j.febslet.2013.06.015. Epub 2013 Jun 19. PMID:23792157
Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology. Hazrati LN, Tartaglia MC, Diamandis P, Davis KD, Green RE, Wennberg R, Wong JC, Ezerins L, Tator CH. Front Hum Neurosci. 2013 May 24;7:222. PMID:23745112
Begcevic I, Kosanam H, Martínez-Morillo E, Dimitromanolakis A, Diamandis P, Kuzmanov U, Hazrati LN, Diamandis EP. Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer's disease and age-matched control brains. Clin Proteomics. 2013 May 1;10(1):5. doi: 10.1186/1559-0275-10-5. PMID:23635041
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease.N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14. PMID:23150934
Wong JC, Armstrong MJ, Lang AE, Hazrati LN. Clinicopathological review of pallidonigroluysian atrophy. Mov Disord. 2013 Mar;28(3):274-81. doi: 10.1002/mds.25232. Epub 2012 Oct 31. Review. PMID: 23114877
Wong JC, Visanji NP, Dabek MK, Laposa RR, Hazrati LN Dendritic spine density is altered in a mouse model of Cockayne syndrome. Neuropathol Appl Neurobiol. 2013 Jun;39(4):437-40. doi: 10.1111/j.1365-2990.2012.01305.x. No abstract available. PMID: 23039087