Roberto Melano

Roberto Melano MSc, PhD
Assistant Professor
Department of Laboratory Medicine & Pathobiology
Roberto Melano
Contact Info
T: (647) 792-3430
F: (416) 235-5800
Ontario Agency for Health Protection & Promotion
661 University Ave.
Room 1701
Toronto, ON, M5G 1M1
Appointment Status Primary
Clinical Interests
Clinical Microbiology
Research Interests
Infectious Diseases & Immunopathology, Genetics Genomics & Proteomics


Research Synopsis

My lab is involved in the detection and characterization of resistance mechanisms to different antibiotic families in both Gram-negative and -positive pathogens. Elucidation of genetic platforms and enzymatic activity are part of that molecular characterization. Development of genetic and phenotypic tests is also part of our work through new technologies applied to diagnosis.

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Azithromycin resistance is co-evolving with reduced susceptibility to cephalosporins in Neisseria gonorrhoeae in Ontario, Canada. 2014. Allen VG, Seah C, Martin I, Melano RG. Antimicrob Agents Chemother, 58(5):2528-2534.

Antimicrobial activity of solithromycin against clinical isolates of Legionella pneumophila serogroup 1. 2014. Mallegol J, Fernandes P, Melano RG, Guyard C. Antimicrob Agents Chemother, 58(2):909-915.

Further proofs of concept for the Carba NP Test – Reply. 2014. Tijet N, Boyd D, Patel SN, Mulvey MR, Melano RG. Antimicrob Agents Chemother, 58(2):1270.

Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. 2013. Tijet N, Boyd D, Patel SN, Mulvey MR, Melano RG. Antimicrob Agents Chemother, 57(9):4578-4580.

Determination of in vitro activity of solithromycin at different pHs and its intracellular activity tested against clinical isolates of Neisseria gonorrhoeae from a laboratory collection. 2013. Mallegol J, Fernandes P, Seah C, Guyard C, Melano RG. Antimicrob Agents Chemother, 57(9):4322-4328.

Verona Integron-encoded Metallo-ß-lactamase in Enterobacteria, Ontario, Canada. 2013. Tijet N, Macmullin G, Lastovetska O, Vermeiren C, Wenzel P, Stacey-Works T, Low DE, Patel SN, Melano RG. Emerg Infect Dis, 19(7):1156-1158.

Cephalosporin resistance in Neisseria gonorrhoeae infections – Reply. 2013. Allen VG, Melano RG, Low DE. JAMA, 309(19):1989-1991.

Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. 2013. Allen VG, Mitterni L, Seah C, Rebbapragada A, Martin IE, Lee C, Siebert H, Towns L, Melano RG, Low DE. JAMA, 309(2):163-170.

Outbreak of carbapenem resistant Enterobacteriaceae containing blaNDM-1, Ontario, Canada. 2012. Borgia S, Lastovetska O, Richardson D, Eshaghi A, Xiong J, Chung C, Baqi M, McGeer A, Ricci G, Sawicki R, Pantelidis R, Low DE, Patel SN, Melano RG. Clin Infect Dis, 55(11):e109-117.

MupB, a new higH-level mupirocin resistance mechanism in Staphylococcus aureus. 2012. Seah C, Alexander DC, Louie L, Simor A, Low DE, Longtin J, Melano RG. Antimicrob Agents Chemother, 56(4):1916-1920.

Distribution of antiseptic-resistance genes qacA/B and smr in methicillin-resistant Staphylococcus aureus isolated in Toronto, 2005-2009. 2011. Longtin J, Seah C, Siebert K, McGeer A, Simor A, Longtin Y, Low DE, Melano RG. Antimicrob Agents Chemother, 55(6):2999-3001.

Comparative evaluation of a chromogenic agar medium, the modified Hodge test, and a battery of meropenem-inhibitors discs for the detection of carbapenemase activity in Enterobacteriaceae. 2011. Seah C, Low DE, Patel SN, Melano RG. J Clin Microbiol, 49(5):1965-1969.

New Delhi metallo-ß-lactamase, Ontario, Canada. 2011. Tijet N, Alexander DC, Richardson D, Lastovetska O, Low DE, Patel SN, Melano RG. Emerg Infect Dis, 17(2):304-305.

rmtD2, a new allele of a 16S rRNA methylase, is present in Enterobacteriaceae from Argentina for more than a decade. 2011. Tijet N, Andres P, Chung C, Lucero C; WHONET-Argentina Group, Low DE, Galas M, Corso A, Petroni A, Melano RG. Antimicrob Agents Chemother, 55(2): 904–909.

Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae from Ontario, Canada. 2011. Allen VG, Farrell DJ, Rebbapragada A, Tan J, Tijet N, Perusini SJ, Towns L, Lo S, Low DE, Melano RG. Antimicrob Agents Chemother, 55(2): 703–712.