LMP1104H: Current understanding of Ischemic heart disease

Who can attend

There are no prerequisites for this course.

Course description

We will critically explore, in depth, Ischemic heart disease, which is a major topic in cardiovascular pathology.

Each week, we will identify, present and discuss gaps in knowledge in understanding the pathogenesis of ischemic heart disease.

You will present recent high-quality peer reviewed original research papers on the cell and molecular pathogenesis of the condition and relate these papers to current literature.

Your presentation will focus on cell and molecular biology, discovery sciences and translational research in cardiovascular disease. Following your presentation, the class will discuss.

The format of each two-hour weekly seminar is:

  • a brief introduction by the instructor
  • assigned student presentations on the topic of the day
  • full class discussion.

Course coordinator

Dr. Avrum I. Gotlieb

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered in odd years (i.e. years ending in 1,3, 5, etc.) in the Fall session.

Day and time TBC

Location: in-person

Evaluation methods

Quiz - 30% (short answers)

Participation in seminar discussions-20% (At all the seminars)

Final Assignment - 50%

You will be assigned a topic in the second week of the course by the instructor and must submit it on the last day of the course.

You will write a six-page report (excluding references, tables and figures) on the major gaps in knowledge on a specific topic in ischemic heart disease research.

You should discuss the rational for choosing these gaps and how research in cell/molecular biology can fill these gaps in knowledge.

You should use high quality, up-to-date references to develop your report.


All sessions are led by Dr. Avrum I. Gotlieb.

Lecture - dates TBC


Lecture 1

Cardiac Muscle Biology and Metabolism I

Lecture 2

Cardiac Muscle Biology and Metabolism II

Lecture 3

Pathobiology of Ischemia

Lecture 4

Myocardial Injury, Death and Repair

Lecture 5

Stem/ Progenitor Cell

Lecture 6

Future considerations


Report submission