LMP402H1 - Inflammation and Infection 24L

Course description 

Mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response, and resolve the infection.  

We will discuss the primary research articles.  

Topics include:

  • commensal bacteria;
  • bacterial toxins;
  • pattern recognition receptors;
  • leukocyte emigration;
  • chemotaxis; and
  • the role of non-coding RNAs in immunity.

Course coordinators

Dr. Myron Cybulsky

Office address: Toronto General Hospital, 101 College St, Rm 3-306

 myron.cybulsky@utoronto.ca

Dr. Jeremy Mogridge

Office address: 1 King’s College Circle, MSB 6306

jeremy.mogridge@utoronto.ca

Teaching assistant

Justin Meade

justin.meade@mail.utoronto.ca

 

Term

Fall 2021

Class location and time

Tuesday and Thursday 11:00 am - 12:30 pm

MSB 4279

Office hours

  Contact instructors

Course details

  • Hours: 24L
  • Prerequisite: (IMM340H1IMM350H1)/( IMM341H1IMM351H1)/(MGY377H1MGY378H1)
  • Exclusions: none
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 40 students

Student evaluation

In-class mid-terms:100%

See information on Academic Integrity

Schedule

Date

Topic

Instructor

September 9, 2021

Commensal bacteria I

Dr. Jeremy Mogridge

September 14, 2021

Commensal bacteria II

Dr. Jeremy Mogridge

September 16, 2021

Pathogenic bacteria I

Dr. Jeremy Mogridge

September 21, 2021

Pathogenic bacteria II

Dr. Jeremy Mogridge

September 23, 2021

Research article

Dr. Jeremy Mogridge

September 28, 2021

Overview of acute and chronic inflammation

Dr. Myron Cybulsky

September 30, 2021

Inflammatory mediators

Corey Scipione

October 5, 2021

Leukocyte emigration I

Dr. Myron Cybulsky

October 7, 2021

Leukocyte emigration II

Dr. Myron Cybulsky

October 12, 2021

Term test 1: Lectures 1-7 (35%)

 

October 14, 2021

Leukocyte emigration III

Dr. Myron Cybulsky

October 19, 2021

Lipopolysaccharide detection

Dr. Jeremy Mogridge

October 21, 2021

Inflammasomes

Dr. Jeremy Mogridge

October 26, 2021

Phagocytosis

Dr. Jeremy Mogridge

October 28, 2021

Neutrophil extracellular traps

Dr. Jeremy Mogridge

November 2, 2021

Chemotaxis and cell migration

Dr. Myron Cybulsky

November 4, 2021

Term test 2: Lectures 8-15 (40%)

 

November 9, 2021

Reading week

 

November 11, 2021

Reading week

 

November 16, 2021

Control of immunity by non-coding RNA

Dr. Jason Fish

November 18, 2021

Feedback regulation of innate immunity

Dr. Jason Fish

November 23, 2021

Inflammatory cell death

Dr. Jeremy Mogridge

November 25, 2021

Resolution of inflammation

Dr. Jeremy Mogridge

November 30, 2021

Research article

Dr. Jeremy Mogridge

December 2, 2021

No class

 

December 7, 2021

Term test 3: Lectures 16-20 (25%)

 

Recommended readings or text book

None