LMP406H1 - Pathobiology of the Cardiovascular System 24L

Course overview

You will learn about, with emphasis is on the underlying cell biology, the following processes:

  • Pathobiology of the heart and blood vessels.
  • Congenital and acquired diseases of the vasculature.
  • Treatments of vascular disease and cardiovascular biomaterials.
  • Major focus on atherosclerosis and hypertension. 

By the end of this course, you should be able to complete the following:

  1. Describe the pathogenesis of vascular diseases including atherosclerosis and hypertension
  2. Discuss mechanisms and signaling cascades that facilitate disease development/progression
  3. Compare and contrast advantages and limitations of experimental models in CV research
  4. Design experiments to test the potential effects of protein X malfunction in the CV system

Using Quercus

Quercus (UTORID needed)

You will access all course materials and submit all work via Quercus for this course.

We will use this platform to make all announcements and communications to you.

Please email the course instructor or TA directly when you need them.

Course coordinator

Dr. Jason Fish

University Health Network (UHN): Toronto General Hospital


Course instructor

Amanda Mohabeer


Teaching assistant

Quinn Bonafiglia


Term Winter 2021
Class location and time

Tuesday 10:00 am-12:00 pm

Online Synchronous (Bb Collaborate)

Office hours

Tuesdays 1-3 pm via Zoom.

Please email to meet outside of these hours.

Course details

  • Hours: 24 L
  • Prerequisites: PSL300H1, PSL301H1 or PSL302Y1
  • Exclusions: None
  • Distribution Requirements: Science
  • Breadth Requirement: Living Things and Their Environment (4)
  • Enrollment limit: Yes – 30 students
  • Required Readings: None, only lecture notes/slides

Student evaluation

Mid-term Assessment: 30%   Due date: February 9 (in class)

Article Review Assignment: 15%  Due date: March 23 (11:59pm)

Final Assessment: 55% Due date to be announced 

Midterm and final assessments

Assessments are not cumulative.

The midterm will cover all lectures prior to February 9 and will be during class hours.

The Final assessment will cover lectures from Feb 23 to the end of term. The final assessment is scheduled through the university and will occur during the end of term period.

The format will be short answer questions. Each guest lecturer will submit and mark their own questions. Study materials include all lecture slides.

Article Review Assignment

Each student will be assigned a primary research article to prepare a written review on during the first week of class.

Each article will be selected by the course lecturers and be relevant to a topic discussed in the course. Each review assignment will consist of a summary of the major findings, impact of study, limitations and proposal of 1-2 additional experiments to validate or build upon the research claims.

Detailed word limits, guidelines, and rubric will be available on Quercus during the first week of class.

All submissions will be uploaded electronically to Quercus by 11:59pm. Late submissions are subjected to a 3% penalty per day (including weekends) up to five days (15%).

Lectures and recordings

All lectures will be delivered synchronously online. Students are expected to attend sessions, however, all lectures will be recorded and available for the entirety of the course.

Lectures and content are the intellectual property of the lecturer and should not be used without permission. 

See information on Academic Integrity



Date topic instructor
January 12 Introduction to the cardiovascular system and atherosclerosis Amanda Mohabeer
January 19 microRNA regulation in atherosclerosis Kathryn Howe
January 26 Hypertension Scott Heximer
February 2 Cardiovascular Regeneration Sara Vasconcelos
February 9 Midterm assessment (in class)  
February 16 Reading week  
February 23 Circadian rhythms and microvascular function Jeffery Kroetsch
March 2 Inflammatory Mechanisms Myron Cybulsky
March 9 Pulmonary Hypertension Quinn Bonafiglia
March 16 Vascular Development Paul Delgado
March 23 Vascular Malformations Jason Fish
March 30 Arterial Stiffening Amanda Mohabeer
April 6 Aneurysms, experimental models, and case studies Amanda Mohabeer