LMP406H1 - Pathobiology of the Cardiovascular System 24L

Course description

You will learn about, with emphasis is on the underlying cell biology, the following processes:

  • Pathobiology of the heart and blood vessels.
  • Congenital and acquired diseases of the vasculature.
  • Treatments of vascular disease and cardiovascular biomaterials.
  • Major focus on atherosclerosis and hypertension. 

By the end of this course, you should be able to complete the following:

  1. Describe the pathogenesis of vascular diseases including atherosclerosis and hypertension
  2. Discuss mechanisms and signaling cascades that facilitate disease development/progression
  3. Compare and contrast advantages and limitations of experimental models in CV research
  4. Design experiments to test the potential effects of protein X malfunction in the CV system

Using Quercus

Quercus (UTORID needed)

You will access all course materials and submit all work via Quercus for this course.

We will use this platform to make all announcements and communications to you.

Please email the course instructor or TA directly when you need them.

Course coordinators

Dr. Jason Fish

101 College St., MaRS, Rm 3-308, Toronto, Ontario Canada M5G 2C4

Teaching assistant

Quinn Bonafiglia



Winter 2022

Class location and time

Tuesday 10 am - 12 pm


Office hours

Tuesdays 1 - 3 pm via Zoom.

Please email to meet outside of these hours.

Course details

  • Hours: 24L
  • Prerequisite: PSL300H1, PSL301H1 or PSL302Y1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Mid-term Assessment (February 15, 2022): 40% (in class)

Article Review Assignment (March 29, 11:59 pm): 20%

Final Assessment: 40% 

Midterm and final assessments

Assessments are not cumulative.

The midterm will cover all lectures prior to February 15 and will be during class hours.

The Final assessment will cover lectures from March 1 to the end of term. The final assessment is scheduled through the university and will occur during the end of term period.

The format will be short answer questions. Each guest lecturer will submit and mark their own questions. Study materials include all lecture slides.

Article Review Assignment

Each student will be assigned a primary research article to prepare a written review on during the first week of class.

Each article will be selected by the course lecturers and be relevant to a topic discussed in the course.

Each review assignment will consist of:

  1. a summary of the major findings
  2. impact of study
  3. limitations and proposal of 1-2 additional experiments to validate or build upon the research claims.

Detailed word limits, guidelines, and rubric will be available on Quercus during the first week of class.

All submissions will be uploaded electronically to Quercus by 11:59 pm on the due date. Late submissions are subjected to a 3% penalty per day (including weekends) up to five days (15%).

Lectures and recordings

All lectures will be delivered synchronously online. Students are expected to attend sessions, however, all lectures will be recorded and available for the entirety of the course.

Lectures and content are the intellectual property of the lecturer and should not be used without permission. 

See information on Academic Integrity





January 11, 2022

Introduction to the cardiovascular system and atherosclerosis

Quinn Bonafiglia

January 18, 2022

Animal models of atherosclerosis

Michelle Bendeck

January 25, 2022

Inflammatory mechanisms of atherosclerosis

Myron Cybulsky

February 1, 2022

microRNA regulation in atherosclerosis

Kathryn Howe

February 8, 2022

Cardiovascular Regeneration

Sara Vasconcelos

February 15, 2022

Midterm assessment (in class)

February 22, 2022

Reading week


March 1, 2022

Circadian rhythms and microvascular function

Jeffery Kroetsch

March 8, 2022

Pulmonary Hypertension

Quinn Bonafiglia

March 15, 2022

Vascular Development

Paul Delgado

March 22, 2022

Vascular Malformations

Jason Fish

March 29, 2022

Vessel Stiffening

Amanda Mohabeer

Recommended reading or text book