LMP408H1 - Genetic Modelling of Human Development and Disease 24L

Course description

An introduction of the use of genetic model systems and organisms in exploring aspects of human reproduction, development, and disease.

We focus on the impact of the genetic models on understanding human health, and disease.

You will learn about the ethical issues in animal research, genetic manipulation, and disease modeling.

Course coordinator

Dr. David Irwin

Office address: 1 King’s College Circle, MSB 6211


Teaching assistant

Negin Khosraviani




Fall 2021

Class location and time

Thursday 9:10 - 11:00 am

Medical Sciences Building Room 3278

Lectures and office hours will be held online unless otherwise announced,
see Quercus for ZOOM links

Office hours

Monday 10:10 - 11:00 am via Zoom

Course details

  • Hours: 24L
  • Prerequisite: LMP300Y1/( LMP340H1, LMP350H1)/ BIO260H1/HMB265H1
  • Exclusions: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Mid-term assessment: 25%

Participation: 10%

Group activity: 15%

Project activity: 25%

Final assessment: 25%

See information on Academic Integrity





September 9, 2021


Dr. David Irwin

September 16, 2021

Model species used in biology

Dr. David Irwin

September 23, 2021

Bioinformatic analysis of data from model species

Dr. David Irwin

September 30, 2021

Scientific debate of genetic model papers (group activity - 10%)

Dr. David Irwin

Teaching Assitant (TA)

October 7, 2021

Phenotate biomedical crowdsourcing database (group activity - 5%)

Dr. David Irwin

Teaching Assitant (TA)

October 14, 2021

Midterm (25%)


October 21, 2021

Zebrafish in vascular development

Dr. Jason Fish

October 28, 2021

Yeast models of human disease

Dr. Karim Mekhail

November 4, 2021

Stem/iPS cells in modeling human development and disease

Dr. Ian Rogers

November 11, 2021

Reading week, no class


November 18, 2021

Mouse modeling of human diseases

Dr. Razq Hakem

November 25, 2021


Negin Khosraviani (TA)

December 2, 2021

Student project presentations (Project activity - 25%)



Final assessment (25%)


Recommended reading or text book

None. Students will be expected to read assigned papers from scientific journals