LMP408H1 - Genetic Modelling of Human Development and Disease 24L

Course description

Introduces the use of genetic model systems and organisms in exploring aspects of human reproduction, development, and disease.

A major focus is on the impact of the genetic models on understanding human health, and disease.

Ethical issues in animal research, genetic manipulation, and disease modeling are highlighted.

Course coordinator

Dr. David Irwin

Office address: 1 King’s College Circle, MSB 6211


Teaching assistant

Negin Khosraviani



Term Fall 2020
Class location and time

Thursday 9:00-11:00 am

Online Synchronous

Tutorial location and time  TBA
Office hours Thursday 11 am-1 pm

Course details

  • Hours: 24L
  • Prerequisite: LMP340H1, LMP350H1/ BIO260H1/​HMB265H1
  • Exclusions: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

In-class mid-term: 35%

Group activity:15%

Project activity: 10%

Final exam: 40%

See information on Academic Integrity



date topic instructor
September 5 Introduction David Irwin
September 12 Model species used in biology David Irwin
September 19 Bioinformatic analysis of data from model species David Irwin
September 26 Scientific debate of genetic model papers (group activity - 10%)

David Irwin

Teaching Assitant (TA)

October 3 Phenotate biomedical crowdsourcing database (group activity - 5%)

Jixuan Wang

Teaching Assitant (TA)

October 10 Midterm (35%)  
October 17 Zebrafish in vascular development Jason Fish
October 24 Flies in neurodegeneration Jeehye Park
October 31 Stem/iPS cells in modeling human development and disease Ian Rogers 
November 7 Reading week  
November 14 Mouse modeling of human diseases Razq Hakem
November 21 TBC  
November 28 Student project presentations (individual/group activity - 10%)  
TBC Final Exam (40%)  

Recommended reading or text book

None. Students will be expected to read assigned papers from scientific journals