Creating Liver Endothelium from hPSCs for Therapy and Discovery
As part of our Monday seminar series, we are delighted to welcome our speaker:
Talk title: Creating Liver Endothelium from hPSCs for Therapy and Discovery
Dr. Blair Gage, PhD
Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Hosted By
How to join
The event will be in person only, no need to register.
MSB 2170
Medical Sciences Building
University of Toronto
1 King’s College Circle
Toronto, ON M5S 1A8
Details are sent to the LMP community in the Friday events bulletin.
If you have any questions about this event, please contact lmp.seminars@utoronto.ca.
Speaker: Dr. Blair Gage
Blair K. Gage (PhD) is a Scientist at the Ottawa Hospital Research Institute in the Regenerative Medicine Program. After a BSc in Biotechnology from UBC and BCIT, he completed a PhD in Cell and Developmental Biology exploring how transcription factors regulated pancreatic endocrine subtype specification from human pluripotent stem cells. His postdoctoral work shifted to generate organ-specific endothelial cells of the liver from human pluripotent stem cells to create potential cell-based and cell-informed therapeutics for liver disease and Hemophilia A. Dr. Gage started his lab in December 2023 and focuses on understanding how endothelial cells gain and maintain organ specific functions to build new therapies for human liver diseases where these functions are lost. The Gage lab’s primary research model is human pluripotent stem cells which are differentiated to become endothelial cells that can be transplanted in mice where they durably engraft and become functional. This research model and approach has potential therapeutic value as delivery of stem cell-derived endothelial cells to mouse models of Hemophilia A resulted in correction of the severe bleeding disorder by sustained production of bioactive coagulation factors. Building on this cell-based therapy leverages many computational, genetic, and molecular approaches to identify and apply new therapies aimed at controlling endothelial function to fight disease.
