LMP1108H: Genome analysis in medicine
Who can attend
There are no prerequisites for this course.
Course description
The advent of next-generation sequencing technologies coupled with decreasing cost has accelerated the pace of gene discovery and revolutionized DNA based diagnostics.
You will become familiar with current methods in the analysis and medical interpretation of genomic sequence data.
By the end of this course you will understand how to:
- analyze a genome
- interpret a genome
You will follow the steps of genomic analysis and complete assignments each week that use the resources we discuss in lectures.
You will complete a term project to analyze a raw genome sequence and report on the relevant findings.
Course coordinators
Dr. Christian Marshall
crm@sickkids.ca
Dr. Michelle Axford
michelle.axford@sickkids.ca
lmp.grad@utoronto.ca for administrative queries.
Timings and location
This course is offered every odd year in the Winter session (i.e. 2021, 2023 etc).
Thursdays 1 – 4 pm
Location: Online
Evaluation methods
Weekly assignments - 50%
Term project - 50%
Schedule
Date |
Topic |
Lecturer/instructor |
---|---|---|
March 2, 2023 |
Genome Structure and Variation |
|
March 9, 2023 |
Genome Sequencing Methodologies |
|
March 16, 2023 |
Informatics Approaches to Genomic Analysis |
|
March 23, 2023 |
Genome Filtering, Interpretation, and Reporting |
|
March 30, 2023 |
Medical and Diagnostic Applications of Genome Analysis |
|
April 6, 2023 |
Term Project Discussion |