LMP1108H: Genome analysis in medicine

Who can attend

There are no prerequisites for this course.

Course description

The advent of next-generation sequencing technologies coupled with decreasing cost has accelerated the pace of gene discovery and revolutionized DNA based diagnostics.

You will become familiar with current methods in the analysis and medical interpretation of genomic sequence data.

By the end of this course you will understand how to:

  • analyze a genome
  • interpret a genome

You will follow the steps of genomic analysis and complete assignments each week that use the resources we discuss in lectures.

You will complete a term project to analyze a raw genome sequence and report on the relevant findings.

Course coordinators

Dr. Christian Marshall

crm@sickkids.ca

Dr. Michelle Axford

michelle.axford@sickkids.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every odd year in the Winter session (i.e. 2021, 2023 etc).

Tuesdays 1 pm – 4 pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Weekly assignments - 50%

Term project - 25%

Final exam - 25%

Schedule

Date

Topic

Lecturer/instructor

March 2, 2021

Genome Structure and Variation

Dr. Michelle Axford

March 9, 2021

Genome Sequencing Methodologies

Dr. Christian Marshall

March 16, 2021

Informatics Approaches to Genomic Analysis

Dr. Christian Marshall

March 23, 2021

Genome Annotation and Interpretation

Dr. Michelle Axford

March 30, 2021

Medical and Diagnostic Applications of Genome Analysis

Dr. Christian Marshall

April 6, 2021

Term Project and Exam

Dr. Michelle Axford

Dr. Christian Marshall