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LMP1203H: Basic principles of analytical clinical biochemistry

Who can attend

The course is open to medical biochemistry residents, postdoctoral diploma in clinical chemistry fellows, and graduate students.

Graduate students need permission from the supervisor and must be registered in the LMP graduate program to attend.

Prerequisites

Undergraduate course in biochemistry and/or molecular biology is recommended.

Course description

This course introduces current analytical techniques as applied in clinical biochemistry laboratories. We will cover the theoretical aspects of each technique, the limitations, and common applications. The course also introduces analytical and clinical evaluation of laboratory methods.

The course will be run as tutorials/lectures for medical biochemistry residents, postdoctoral diploma in clinical chemistry fellows, and graduate students.

Course coordinator

Dr. Davor Brinc

davor.brinc@uhn.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every year in the Fall session.

  • Wednesdays, 9 am - 12 noon
  • Location: Health Sciences Building (155 College Street) Room 705

Meetings will take place on Wednesday mornings (9:00-12:00 noon). Alternative meeting times and places may be arranged with individual lecturers if deemed necessary.

Readings

Students are responsible for the material provided in the lectures.

Optional readings

Selected chapters from N. Rifai et al (editors). Tietz Textbook of Laboratory Medicine.

Supplementary readings can also be provided by each lecturer.

Evaluation methods

  • Take-home assignment: 30% 
  • Mid-term: 35% 
  • Final exam: 35%  

Schedule

Date

Topic

Lecturer/instructor

September 3, 2025

Introduction to analytical clinical biochemistry and analytical method evaluation 

Dr. Jessica Miller, UHN

(jessica.miller@uhn.ca )

September 10, 2025

Clinical method evaluation

Dr. Dorothy Truong, LifeLabs

(dorothy.truong@lifelabs.com) 

September 17, 2025

General lab techniques

Dr. Ashley DiMeo, UHN

(ashley.dimeo2@uhn.ca)

September 24, 2025

Electrophoresis

Dr. Saranya Arnoldo, Trillium

(saranya.arnoldo@thp.ca)

October 1, 2025

Electrochemistry applications in clinical chemistry laboratory 

Dr. Mohamed Abouelhassan, LifeLabs

(mohamed.abouelhassan@lifelabs.com)

October 8, 2025

Enzymatic techniques and chemistry analyzers  

Dr. Felix Leung, Mount Sinai Hospital

(felix.leung@sinaihealth.ca)

October 15, 2025

Midterm

Dr. Davor Brinc, UHN

(davor.brinc@uhn.ca)

October 22, 2025

Spectrophotometry

Dr. Matthew Lafreniere, Sunnybrook Health Sciences Centre

(matthew.lafreniere@sunnybrook.ca)

October 29, 2025

Immunoassays I

Dr. Paul Yip, Sunnybrook Health Sciences Centre

(paul.yip@sunnybrook.ca)

November 5, 2025

Immunoassays II

Dr. Paul Yip, Sunnybrook Health Sciences Centre

November 12, 2025

Chromatography

Dr. Daniel Beriault, Unity Health Toronto

(daniel.beriault@unityhealth.to)

November 19, 2025

Mass Spectrometry 

Dr. Jessica Miller, UHN

(jessica.miller@uhn.ca)

November 26, 2025

Point-of-care testing

Dr. Davor Brinc, UHN

December 3, 2025

Molecular diagnostics

Dr. Cuihong Wei, UHN

(cuihong.wei@uhn.on.ca)

December 10, 2025

Ultracentrifugation and lipid analyses

Dr. Dana Bailey, LifeLabs

(dana.nyholt@lifelabs.com)

December 17, 2025

Final exam

Dr. Davor Brinc, UHN