LMP1203H: Basic principles of analytical clinical biochemistry

Who can attend

The course is open to medical biochemistry residents, postdoctoral diploma in clinical chemistry fellows, and graduate students.

Graduate students need permission from the supervisor and must be registered in the LMP graduate program to attend.

Prerequisites

Undergraduate course in biochemistry and/or molecular biology is recommended.

Course description

This course introduces current analytical techniques as applied in clinical biochemistry laboratories. We will cover the theoretical aspects of each technique, the limitations, and common applications. The course also introduces analytical and clinical evaluation of laboratory methods.

The course will be run as tutorials/lectures for medical biochemistry residents, postdoctoral diploma in clinical chemistry fellows, and graduate students.

Course coordinator

Dr. Davor Brinc

davor.brinc@uhn.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every year in the Fall session.

Wednesdays, 9 am - 12 noon

Location: SS 2112 (Sidney Smith Hall) 

Meetings will take place on Wednesday mornings (9:00-12:00 noon). Alternative meeting times and places may be arranged with individual lecturers if deemed necessary.

Readings

Students are responsible for the material provided in the lectures.

Optional readings

Selected chapters from N. Rifai et al (editors). Tietz Textbook of Laboratory Medicine.

Supplementary readings can also be provided by each lecturer.

Evaluation methods

  • Take-home assignment: 10% 
  • Mid-term (sessions 1 to 6): 40% 
  • Final exam (session 7, 9-15): 50%  

Schedule

Lectures will be in person unless stated via Zoom. Zoom details will be provided by email.

Date

Topic

Lecturer/instructor

September 4, 2024

Introduction to analytical clinical biochemistry and analytical method evaluation 

Dr. Jessica Miller, UHN

(jessica.miller@uhn.ca )

September 11, 2024

Clinical method evaluation

Online via Zoom

Dr. Dorothy Truong, LifeLabs

(dorothy.truong@lifelabs.com) 

September 18, 2024

General lab techniques

Dr. Ashley DiMeo, UHN

(ashley.dimeo2@uhn.ca)

September 25, 2024

Electrochemistry applications in clinical chemistry laboratory 

Online via Zoom

Dr. Mohamed Abouelhassan, LifeLabs

(mohamed.abouelhassan@lifelabs.com)

October 2, 2024

Enzymatic techniques and chemistry analyzers  

Dr. Felix Leung, Mount Sinai Hospital

(felix.leung@sinaihealth.ca)

October 9, 2024

Electrophoresis

Dr. Saranya Arnoldo, Trillium

(saranya.arnoldo@thp.ca)

October 16, 2024

Spectrophotometry

Online via Zoom

Dr. Uvaraj Uddayasankar, LifeLabs

(uvaraj.uddayasankar@lifelabs.com)

October 23, 2024

Midterm

Dr. Davor Brinc, UHN

(davor.brinc@uhn.ca)

October 30, 2024

Immunoassays I

Dr. Paul Yip, Sunnybrook Health Sciences Centre

(paul.yip@sunnybrook.ca)

November 6, 2024

Immunoassays II

Dr. Paul Yip, Sunnybrook Health Sciences Centre

November 13, 2024

Chromatography

Dr. Daniel Beriault, Unity Health Toronto

(daniel.beriault@unityhealth.to)

November 20, 2024

Mass Spectrometry 

Dr. Andrea Bozovic, UHN

(andrea.bozovic@uhn.ca)

November 27, 2024

Point-of-care testing

Dr. Davor Brinc, UHN

December 4, 2024

Molecular diagnostics

Dr. Cuihong Wei, UHN

(cuihong.wei@uhn.on.ca)

December 11, 2024

Ultracentrifugation and lipid analyses

Dr. Dana Bailey, Dynacare

(BaileyD@dynacare.ca)

December 18, 2024

Final exam

Dr. Davor Brinc, UHN