LMP440H1 – Mechanisms of Host-Microbe Interactions

Course description

You will learn about the mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection. We will discuss primary research articles.

Topics include:

  • commensal and pathogenic bacteria
  • microbe recognition
  • programmed cell death
  • immunometabolism
  • inflammatory diseases.

Course coordinators

Dr. Jeremy Mogridge

Office address: 1 King’s College Circle, MSB Room 6306

Dr. Stephen Girardin

Office address: 1 King’s College Circle, MSB Room 6304

Teaching assistant



Fall 2024

Class time

Wednesday 1 - 3 pm

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L
  • Prerequisite: (IMM340H1, IMM350H1)/ (IMM341H1, IMM351H1) / 
    (MGY377H1, MGY378H1) / LMP310H1
  • Exclusions: LMP402H1, LMP436H1 
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Midterm: 45% (lectures 1 - 5)

Assignment: 10%

Final Exam: 45% (lectures 7 - 11)

See information on Academic Integrity

Schedule for Fall 2024

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus




September 13

Mechanisms in bacterial pathogenesis

Dr. Jeremy Mogridge

September 20

Introduction to infectious disease

Dr. Stephen Girardin

September 27

Commensal bacteria

Dr. Dana Philpott

October 4

Pathogen detection I

Dr. Jeremy Mogridge

October 11

Pathogen detection II

Dr. Stephen Girardin

October 18

Research article critique

(Assignment due: 10%)


October 25

Midterm Exam (Lectures 1 - 5: 45%)


November 1

Host defense mechanisms

Dr. Stephen Girardin

November 8

Reading week


November, 15

Cell death mechanisms

Dr. Jeremy Mogridge

November 22


Dr. Jeremy Mogridge

November 29

Resolution of inflammation

Dr. Jeremy Mogridge

December 6

Host-microbe interactions and inflammatory disease

Dr. Stephen Girardin

Recommended reading or text book