LMP440H1 – Mechanisms of Host-Microbe Interactions
Course description
You will learn about the mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection. We will discuss primary research articles.
Topics include:
- commensal and pathogenic bacteria
- microbe recognition
- programmed cell death
- immunometabolism
- inflammatory diseases.
Course coordinators
Office address: 1 King’s College Circle, MSB Room 6306
jeremy.mogridge@utoronto.ca
Office address: 1 King’s College Circle, MSB Rm 6304
stephen.girardin@utoronto.ca
Teaching assistant
Justin Meade
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Term |
Fall 2022 |
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Class location and time |
TBC |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L
- Prerequisite: (IMM340H1, IMM350H1)/ (IMM341H1, IMM351H1) /
(MGY377H1, MGY378H1) / LMP310H1 - Exclusions: LMP402H1, LMP436H1
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
TBC
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
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Lecture 1 |
Introduction to infectious disease |
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Lecture 2 |
Mechanisms in bacterial pathogenesis |
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Lecture 3 |
Commensal bacteria |
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Lecture 4 |
Pathogen detection I |
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Lecture 5 |
Pathogen detection II |
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Lecture 6 |
Research article critique |
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Lecture 7 |
Host defense mechanisms |
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Lecture 8 |
Cell death mechanisms |
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Lecture 9 |
Immunometabolism |
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Lecture 10 |
Resolution of inflammation |
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Lecture 11 |
Host-microbe interactions and inflammatory disease |
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Lecture 12 |
Research Article critique |
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Recommended reading or text book
None.