LMP440H1 – Mechanisms of Host-Microbe Interactions

Course description

You will learn about the mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection. We will discuss primary research articles.

Topics include:

  • commensal and pathogenic bacteria
  • microbe recognition
  • programmed cell death
  • immunometabolism
  • inflammatory diseases.

Course coordinators

Dr. Jeremy Mogridge

Office address: 1 King’s College Circle, MSB Room 6306
jeremy.mogridge@utoronto.ca

Dr. Stephen Girardin

Office address: 1 King’s College Circle, MSB Rm 6304
stephen.girardin@utoronto.ca

Teaching assistant

Justin Meade

justin.meade@mail.utoronto.ca

Term

Fall 2022

Class location and time

TBC

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L
  • Prerequisite: (IMM340H1, IMM350H1)/ (IMM341H1, IMM351H1) / 
    (MGY377H1, MGY378H1) / LMP310H1
  • Exclusions: LMP402H1, LMP436H1 
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

TBC

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

Lecture 1

Introduction to infectious disease

 

Lecture 2

Mechanisms in bacterial pathogenesis

 

Lecture 3

Commensal bacteria

 

Lecture 4

Pathogen detection I

 

Lecture 5

Pathogen detection II

 

Lecture 6

Research article critique

 

Lecture 7

Host defense mechanisms

 

Lecture 8

Cell death mechanisms

 

Lecture 9

Immunometabolism

 

Lecture 10

Resolution of inflammation

 

Lecture 11

Host-microbe interactions and inflammatory disease

 

Lecture 12

Research Article critique

 

Recommended reading or text book

None.