LMP440H1 – Mechanisms of Host-Microbe Interactions

Course description

You will learn about the mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection. We will discuss primary research articles.

Topics include:

commensal and pathogenic bacteria
microbe recognition
programmed cell death
immunometabolism
inflammatory diseases.

Course coordinators

Dr. Jeremy Mogridge

Office address: 1 King’s College Circle, MSB Room 6306
jeremy.mogridge@utoronto.ca

Dr. Stephen Girardin

Office address: 1 King’s College Circle, MSB Room 6304
stephen.girardin@utoronto.ca

Teaching assistant

Justin Meade

justin.meade@mail.utoronto.ca

Term	Fall 2022
Class time	Wednesday 1 - 3 pm
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L
Prerequisite: (IMM340H1, IMM350H1)/ (IMM341H1, IMM351H1) /
(MGY377H1, MGY378H1) / LMP310H1
Exclusions: LMP402H1, LMP436H1
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

Midterm: 45% (lectures 1 - 5)

Assignment: 10%

Final Exam: 45% (lectures 7 - 11)

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
September 14, 2022	Introduction to infectious disease	Dr. Stephen Girardin
September 21, 2022	Mechanisms in bacterial pathogenesis	Dr. Jeremy Mogridge
September 28, 2022	Commensal bacteria	Dr. Dana Philpott
October 5, 2022	Pathogen detection I	Dr. Jeremy Mogridge
October 12, 2022	Pathogen detection II	Dr. Stephen Girardin
October 19, 2022	Research article critique (Assignment due: 10%)
October 26, 2022	Midterm Exam (Lectures 1 - 5: 45%)
November 2, 2022	Host defense mechanisms	Dr. Stephen Girardin
November 9, 2022	Reading week
November, 16, 2022	Cell death mechanisms	Dr. Jeremy Mogridge
November 23, 2022	Immunometabolism	Dr. Jeremy Mogridge
November 30, 2022	Resolution of inflammation	Dr. Jeremy Mogridge
December 7, 2022	Host-microbe interactions and inflammatory disease	Dr. Stephen Girardin