LMP440H1 – Mechanisms of Host-Microbe Interactions

Course description

You will learn about the mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection. We will discuss primary research articles.

Topics include:

commensal and pathogenic bacteria
microbe recognition
programmed cell death
immunometabolism
inflammatory diseases.

Course coordinators

Dr. Jeremy Mogridge

Office address: 1 King’s College Circle, MSB Room 6306
jeremy.mogridge@utoronto.ca

Teaching assistant

Adrienne Ranger

adrienne.ranger@mail.utoronto.ca

Term	Fall 2024
Class time	Wednesday 1 - 3 pm
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L
Prerequisite: (IMM340H1, IMM350H1)/ (IMM341H1, IMM351H1) /
(MGY377H1, MGY378H1) / LMP310H1
Exclusions: LMP402H1, LMP436H1
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

Midterm: 45% (lectures 1 - 5) - due date 16 October, 2024

Assignment: 10% - due date 9 October, 2024

Final Exam: 45% (lectures 7 - 11)

See information on Academic Integrity

Schedule for Fall 2024

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
September 4, 2024	Introduction to infectious disease	Dr. Stephen Girardin
September 11, 2024	Mechanisms in bacterial pathogenesis	Dr. Jeremy Mogridge
September 18, 2024	Pathogen detection I	Dr. Jeremy Mogridge
September 25, 2024	Commensal bacteria	Dr. Dana Philpott
October 2, 2024	Pathogen detection II	Dr. Stephen Girardin
October 9, 2024	Research article critique (Assignment due: 10%)
October 16, 2024	Midterm Exam (Lectures 1 - 5: 45%)
October 23, 2024	Host defense mechanisms	Dr. Stephen Girardin
November 6, 2024	Host-microbe interactions and inflammatory disease	Dr. Stephen Girardin
November, 13, 2024	Cell death mechanisms	Dr. Jeremy Mogridge
November 20, 2024	Immunometabolism	Dr. Jeremy Mogridge
November 27, 2024	Resolution of inflammation	Dr. Jeremy Mogridge