LMP310H1 – Fundamentals of Pathobiology

Course description

Enrolment is limited to students in the Pathobiology specialist program.

This course covers the major molecular mechanisms that impact human health and disease.

It is divided into three blocks that focus on the fundamentals of pathobiology in:

  1. cancer
  2. cardiovascular diseases and
  3. infection

It is intended to introduce the cellular and molecular concepts of health and disease that will be explored with more depth in fourth-year LMP courses.

Course coordinators

Dr. Myron Cybulsky

Office address: UHN, 101 College St, MaRS, Room 3-306 

Dr. Felix Leung

Office address: Sinai Health, 600 University Ave, Room 11C-310

Dr. Sonya MacParland

Office address: UHN, 101 College St, MaRS Room 3-302

Teaching assistant

Stefanie-Grace Sbergio



Fall 2022

Lecture time

Wednesday, 10 am - 12 pm

Tutorial time

Thursday 11 am - 12 pm

Office hours

Contact TA or Course Coordinators

Course details

Enrolment is limited to students in the Pathobiology specialist program.

  • Hours: 24L/12T
  • Prerequisite: LMP200H1, BCH210H1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation

Three in-term midterm tests, scheduled during tutorials (100%)

See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus





Cancer pathobiology


Lecture 1

Introduction to fundamental concepts in cancer biology

Dr. Felix Leung

Lecture 2

Initiation of cancer: predisposition, genetics and environment

Dr. Felix Leung

Lecture 3

Progression of cancer: clonal evolution and tumourigenesis

Dr. Felix Leung

Lecture 4

Invasion of cancer: tumour microenvironment and cell migration

Dr. Felix Leung


Inflammation & Atherosclerosis


Lecture 5

Overview of inflammation in atherosclerosis

Dr. Myron Cybulsky

Lecture 6

Mechanisms of leukocyte emigration I

Dr. Myron Cybulsky

Lecture 7

Mechanisms of leukocyte emigration II

Dr. Myron Cybulsky

Lecture 8

Leukocyte trafficking in atherosclerosis

Dr. Myron Cybulsky




Lecture 9

Immunopathological processes during infection 

Dr. Sonya MacParland

Lecture 10

Immunopathology of autoimmunity

Dr. Sonya MacParland

Lecture 11

Pathobiology of organ transplantation and rejection

Dr. Sonya MacParland

Lecture 12

Host immune evasion by pathogens 

Dr. Sonya MacParland

Recommended reading or text book