LMP310H1 – Fundamentals of Pathobiology
Course description
Enrolment is limited to students in the Pathobiology specialist program.
This course covers the major molecular mechanisms that impact human health and disease.
It is divided into three blocks that focus on the fundamentals of pathobiology in:
- cancer
- cardiovascular diseases and
- infection
It is intended to introduce the cellular and molecular concepts of health and disease that will be explored with more depth in fourth-year LMP courses.
Course coordinators
Office address: UHN, 101 College St, MaRS, Room 3-306
myron.cybulsky@utoronto.ca
Office address: Sinai Health, 600 University Ave, Room 11C-310
felix.leung@sinaihealth.ca
Office address: UHN, 101 College St, MaRS Room 3-302
s.macparland@utoronto.ca
Teaching assistant
Stefanie-Grace Sbergio
stefanie.sbergio@mail.utoronto.ca
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Term |
Fall 2022 |
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Lecture location and time |
Wednesday, 10 am - 12 pm NF 113, Northrop Fyre |
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Tutorial location and time |
Thursday 11 am - 12 pm PB 255, Leslie Dan Pharmacy Building |
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Office hours |
Contact TA or Course Coordinators |
Course details
Enrolment is limited to students in the Pathobiology specialist program.
- Hours: 24L/12T
- Prerequisite: LMP200H1, BCH210H1
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Three in-term midterm tests, scheduled during tutorials (100%)
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
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Cancer pathobiology |
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Lecture 1 |
Introduction to fundamental concepts in cancer biology |
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Lecture 2 |
Initiation of cancer: predisposition, genetics and environment |
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Lecture 3 |
Progression of cancer: clonal evolution and tumourigenesis |
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Lecture 4 |
Invasion of cancer: tumour microenvironment and cell migration |
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Inflammation & Atherosclerosis |
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Lecture 5 |
Overview of inflammation in atherosclerosis |
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Lecture 6 |
Mechanisms of leukocyte emigration I |
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Lecture 7 |
Mechanisms of leukocyte emigration II |
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Lecture 8 |
Leukocyte trafficking in atherosclerosis |
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Immunopathology |
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Lecture 9 |
Immunopathological processes during infection |
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Lecture 10 |
Immunopathology of autoimmunity |
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Lecture 11 |
Pathobiology of organ transplantation and rejection |
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Lecture 12 |
Host immune evasion by pathogens |
Recommended reading or text book
None.