LMP310H1 – Fundamentals of Pathobiology

Course description

Enrolment is limited to students in the Pathobiology specialist program.

This course covers the major molecular mechanisms that impact human health and disease.

It is divided into three blocks that focus on the fundamentals of pathobiology in:

  1. cancer
  2. cardiovascular diseases and
  3. infection

It is intended to introduce the cellular and molecular concepts of health and disease that will be explored with more depth in fourth-year LMP courses.

Course coordinators

Dr. Myron Cybulsky

Office address: UHN, 101 College St, MaRS, Room 3-306 
myron.cybulsky@utoronto.ca

Dr. Felix Leung

Office address: Sinai Health, 600 University Ave, Room 11C-310
felix.leung@sinaihealth.ca

Dr. Sonya MacParland

Office address: UHN, 101 College St, MaRS Room 3-302
s.macparland@utoronto.ca

Teaching assistant

TBC

Term

Fall 2022

Class location and time

TBC

Office hours

Contact TA or Course Coordinators

Course details

Enrolment is limited to students in the Pathobiology specialist program.

  • Hours: 24L/12T
  • Prerequisite: LMP200H1, BCH210H1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation

Three in-term midterm tests, scheduled during tutorials (100%)

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

 

Cancer pathobiology

 

Lecture 1

Introduction to fundamental concepts in cancer biology

Dr. Felix Leung

Lecture 2

Initiation of cancer: predisposition, genetics and environment

Dr. Felix Leung

Lecture 3

Progression of cancer: clonal evolution and tumourigenesis

Dr. Felix Leung

Lecture 4

Invasion of cancer: tumour microenvironment and cell migration

Dr. Felix Leung

 

Cardiovascular pathobiology

 

Lecture 5

Overview of inflammation in atherosclerosis

Dr. Myron Cybulsky

Lecture 6

Mechanisms of leukocyte emigration I

Dr. Myron Cybulsky

Lecture 7

Mechanisms of leukocyte emigration II

Dr. Myron Cybulsky

Lecture 8

Leukocyte trafficking in atherosclerosis

Dr. Myron Cybulsky

 

Immunopathology

 

Lecture 9

Immunopathological processes during infection 

Dr. Sonya MacParland

Lecture 10

Immunopathology of autoimmunity

Dr. Sonya MacParland

Lecture 11

Pathobiology of organ transplantation and rejection

Dr. Sonya MacParland

Lecture 12

Host immune evasion by pathogens 

Dr. Sonya MacParland

Recommended reading or text book

None.