LMP460H1 – Pathobiology of the Cardiovascular System

Course description

This course covers the pathobiology of the heart, blood vessels, and lymphatic system.

The emphasis is on the underlying cell biology of processes such as:

  • Vascular Malformations: congenital and acquired
  • Atherosclerosis: Pathogenesis, Inflammation, Advanced Complications, Animal Models
  • Treatments of vascular disease
  • Regenerative Medicine in the Cardiovascular System

Course coordinators

Dr. Michelle Bendeck

Office address: 661 University Ave, MaRS II, 14th floor, Rm 1432
michelle.bendeck@utoronto.ca

Teaching assistant

Amanda Mao

amanda.mao@mail.utoronto.ca

Term

Winter 2023

Class time

Tuesday 10 am - 12 pm

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L
  • Prerequisite: (PSL300H1, PSL301H1) / PSL302Y1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Midterm test: 40%

Final exam: 60%

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus.

Date

Topic

Instructor

Lecture 1

Vascular and Cardiac Structure and Function

 

Lecture 2

Introduction to atherosclerosis

 

Lecture 3

Animal models of atherosclerosis

 

Lecture 4

Inflammatory Mechanisms of Atherosclerosis

 

Lecture 5

microRNA regulation in atherosclerosis

 

Lecture 6

Cardiovascular regeneration

Lecture 7

Vascular Calcification

 

Lecture 8

Vascular Development

 

Lecture 9

Vascular Malformations

Lecture 10

New Technologies to Monitor CV disease

 

Lecture 11

Tissue Engineering Approaches for cardiovascular disease

 

Recommended reading or text book

None.