LMP460H1 – Pathobiology of the Cardiovascular System

Course description

This course covers the pathobiology of the heart, blood vessels, and lymphatic system.

The emphasis is on the underlying cell biology of processes such as:

  • Vascular Malformations: congenital and acquired
  • Atherosclerosis: Pathogenesis, Inflammation, Advanced Complications, Animal Models
  • Treatments of vascular disease
  • Regenerative Medicine in the Cardiovascular System

Course coordinators

Dr. Michelle Bendeck

Office address: 661 University Ave, MaRS II, 14th floor, Rm 1432

Teaching assistant

Amanda Mao



Winter 2023

Class time

Tuesday 10 am - 12 pm

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L
  • Prerequisite: (PSL300H1, PSL301H1) / PSL302Y1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Midterm test: 40%

Final exam: 60%

See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus.




Lecture 1

Vascular and Cardiac Structure and Function


Lecture 2

Introduction to atherosclerosis


Lecture 3

Animal models of atherosclerosis


Lecture 4

Inflammatory Mechanisms of Atherosclerosis


Lecture 5

microRNA regulation in atherosclerosis


Lecture 6

Cardiovascular regeneration

Lecture 7

Vascular Calcification


Lecture 8

Vascular Development


Lecture 9

Vascular Malformations

Lecture 10

New Technologies to Monitor CV disease


Lecture 11

Tissue Engineering Approaches for cardiovascular disease


Recommended reading or text book