LMP460H1 – Pathobiology of the Cardiovascular System

Course description

This course covers the pathobiology of the heart, blood vessels, and lymphatic system.

The emphasis is on the underlying cell biology of processes such as:

  • congenital diseases of the heart
  • ischemic injury
  • stroke
  • treatments of vascular disease
  • cardiovascular biomaterials
  • atherosclerosis
  • hypertension. 

Course coordinators

Dr. Michelle Bendeck

Office address: 661 University Ave, MaRS II, 14th floor, Rm 1432
michelle.bendeck@utoronto.ca

Teaching assistant

Quinn Bonafiglia

quinn.bonafiglia@mail.utoronto.ca

Term

Winter 2023

Class location and time

Tuesday 10 am - 12 pm

Location TBC

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L
  • Prerequisite: (PSL300H1, PSL301H1) / PSL302Y1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Midterm test: 40%

Article assignment: 20%

Final exam: 40%

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

Lecture 1

Introduction to cardiovascular pathobiology

 

Lecture 2

Vascular development and angiogenesis

 

Lecture 3

Atherogenesis

 

Lecture 4

Platelet function and thrombosis

 

 

Lecture 5

Animal models

 

 

Lecture 6

Inflammatory mechanisms

Lecture 7

Lipids

 

Lecture 8

Hypertension

 

Lecture 9

Clinical perspectives and treatments for athersclerosis

Lecture 10

Vascular malformations

 

Lecture 11

Diabetes and the microvasculature

 

Recommended reading or text book

None.