LMP460H1 – Pathobiology of the Cardiovascular System

Course description

This course covers the pathobiology of the heart and blood vessels.

The emphasis is on the underlying cell biology of processes such as:

Vascular Malformations: congenital and acquired
Atherosclerosis: Pathogenesis, Inflammation, Advanced Complications, Animal Models
Regenerative Medicine in the Cardiovascular System
Wearable monitoring of Cardiovascular Disease

Office address: 661 University Ave, MaRS II, 14th floor, Rm 1432
michelle.bendeck@utoronto.ca

Mary-Jo Hatem

Term	Winter 2026
Class time	Tuesday 11 am - 1 pm
Office hours	Contact TA or Course Coordinators

Hours: 24L
Prerequisite: (PSL300H1, PSL301H1) / PSL302Y1. Pre-requisite waiver requests must be made to the academic unit (lmp.undergraduate@utoronto.ca).
Corequisites: None
Exclusions: LMP406H1
Recommended preparation: None
Credit value: 0.5
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Midterm test: 40%

Final exam: 60%

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus.

Date	Topic
January 6, 2026	Vascular and Cardiac Structure and Function Introduction to Atherosclerosis
January 13, 2026	Animal models of Atherosclerosis
January 20, 2026	Inflammatory Mechanisms of Atherosclerosis
January 27, 2026	Thrombosis and Adhesion Molecules
February 3, 2026	Endothelial cells in Atherosclerosis
February 10, 2026	Midterm
February 17, 2026	Reading Week - no class
February 24, 2026	Heart and Vascular Development
March 3, 2026	Vascular Malformations
March 10, 2026	Heart Valve Pathology and Regenerative Approaches
March 17, 2026	Calcification and Extracellular Matrix Proteins
March 24, 2026	Heart Regeneration
March 31, 2026	Wearable Devices for Hemodynamic Remodeling