LMP1110H: Neural Stem Cells - brain development and maintenance
Who can attend
No specific courses are required, however, we prefer background knowledge in molecular genetics and biochemistry (such as LMP301H1 / BCH242Y / MGY340H1).
- be introduced to the basic concepts of how neural stem/precursor cells both build and maintain the brain
- learn basic concepts of adult neural stem/precursor cell biology and how these cells emerge embryonically
- understand and learn how advanced genetic techniques are being applied to the study of neural stem cell biology
- use these systems, more broadly, as a platform to learn advanced genetic techniques (such as single-cell RNA-sequencing, viral barcoding, and other lineage tracing techniques).
Each week, lecture material will:
- cover aspects of neural stem/precursor cell biology in the developing or mature brain
- introduce a different advanced genetic technique (using primary literature which you will read prior to the lecture)
- describe how this technique has impacted our understanding of neural stem/precursor cell biology.
firstname.lastname@example.org for administrative queries.
Timings and location
This course is offered every year in the Fall session.
Thursdays 10 am
Location: Synchronous online delivery (Zoom)
Final exam – 45%
Participation in class – 10%. You will be assessed based on your participation in the discussion of published papers in the second half of each lecture.
Final assignment – 45%
Your final assignment will be discussed and assigned during Lecture 2.
You will be asked to prepare a short funding-style proposal to either:
- apply an advanced genetic technique (either from those discussed in class or chosen by you) to your own current research project (technique must not be currently used in your thesis project), or;
- propose to address a current gap in neural stem/precursor cell biology (either in the developing or mature brain).
Your proposal must be a maximum of five pages in length including references.
It will evaluated based on the strength of the rationale, experiments proposed and interpretation of anticipated experimental outcomes.
All sessions are delivered by Dr. Scott Yuzwa.
|October 15, 2020||
Introduction to the course
Adult brain: relevant structure and function
|October 22, 2020||
Neural Development I
Discussion of Final Assignment
|October 29, 2020||
Neural Development II
|November 5, 2020||
Neural Stem Cells and their unique niche environments
|November 12, 2020||
Embryonic origins of Adult Neural Stem Cells
Hand in Term Paper
Concluding remarks: What does the future hold?