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Graduate course list
- LMP1001/1002/1003: Graduate Seminars in Laboratory Medicine and Pathobiology
- LMP1005H: Fundamentals of Research Practice
- LMP1100H: Cellular imaging in pathobiology
- LMP1101H: Basic concepts in inflammatory/autoimmune arthritis
- LMP1102H: Clinical concepts in inflammatory/autoimmune arthritis
- LMP1103H: Tissue injury, repair and regeneration
- LMP1105: Current understanding of Atherosclerosis
- LMP1106H: Molecular Biology Techniques
- LMP1107H: Bioinformatics in LMP
- LMP1108H: Genome analysis in medicine
- LMP1110H: Neural Stem Cells - brain development and maintenance
- LMP1111: Introduction to R and the Analysis of Single Cell Data
- LMP1200H: Neoplasia
- LMP1203H: Basic principles of analytical clinical biochemistry
- LMP1206H: Next generation genomics in clinical medicine
- LMP1207H: Mass spectrometry, proteomics and their clinical applications
- LMP1208H: Molecular clinical microbiology and infectious diseases
- LMP1210H - Basic Principles of Machine Learning in Biomedical Research
- LMP1211H: Foundations in Musculoskeletal Science
- LMP2004H: Introduction to Biostatistics
- Fees, stipends, awards & grants
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- Program completion for MSc and PhD
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- Communicate your research: the 3MT in LMP
- Mentoring & professional development for graduate students
- Master of Health Science (MHSc) in Laboratory Medicine
- Master of Science in Applied Computing (MScAC) Artificial Intelligence in Healthcare
- Collaborative Specialization in Musculoskeletal Sciences (CSMS)
- Master of Health Science (MHSc) in Translational Research
- Student Union: CLAMPS
Breadcrumbs
LMP1110H: Neural Stem Cells - brain development and maintenance
Who can attend
No specific courses are required, however, we prefer background knowledge in molecular genetics and biochemistry (such as LMP301H1 / BCH242Y / MGY340H1).
Enrollment is open to University of Toronto graduate students and capped at a maximum of 20 students.
Course description
The major goal of this module is to introduce basic concepts of how neural stem/precursor cells both build and maintain the brain and to use these systems, more broadly, as a platform to learn advanced genetic techniques (such as single-cell RNA-sequencing, viral barcoding, and other lineage tracing techniques).
Each lecture will have the following structure:
- In the first half, lecture material will cover aspects of neural stem cell biology in the developing or mature brain and introduce a different advanced genetic technique (using primary literature which students will read prior to the lecture).
- In the second half of each lecture, assigned student discussion leader(s) will lead a discussion of the data contained in assigned scientific papers and reveal how this technique impacted our understanding of neural stem cell biology.
The course instructor will lead the discussion in Lecture 1 to scaffold the expectations of student discussion leader(s) in subsequent Lecture weeks.
By the end of this course students will be able to:
- Describe basic concepts of neural stem cell biology in brain development and in the mature brain.
- Describe the underlying principles of advanced genetic techniques and how these are being applied to the study of neural stem cell biology.
- Effectively communicate and apply concepts of neural stem cell biology and advanced genetic techniques to primary scientific literature.
- Produce an academic quality ‘mini-grant’ proposal by applying the concepts learned in this course.
Course coordinator
lmp.grad@utoronto.ca for administrative queries.
Timings and location
This course will be offered in alternative years starting Fall 2026 (i.e. 2026, 2028 etc).
Timings: TBA
Location: TBA
Evaluation methods
Final exam – 45%
Participation in class – 10%. You will be assessed based on your participation in the discussion of published papers in the second half of each lecture, attendance, and syllabus quiz.
Final assignment – 45%
Your final assignment will be discussed and assigned during Lecture 2.
You will be asked to prepare a short ‘mini-grant’ proposal to either:
- apply an advanced genetic technique (either from those discussed in class or chosen by the student) to their own current research project (technique must not be currently used in the student’s thesis project) or;
- propose to address a current gap in neural stem cell biology (either in the developing or mature brain).
This proposal must be a maximum of 5 pages in length including references.
Proposals will be evaluated based on the strength of the rationale, experiments proposed, and interpretation of anticipated experimental outcomes.
Schedule
A more detailed course syllabus will be provided to registered students in Quercus. Students should refer to the latter (and Quercus) for all relevant course information for the Fall 2021 section of LMP1110H.
Date |
Topic |
Instructor |
---|---|---|
October 14, 2021 |
Introduction to the course Adult brain: relevant structure and function Technique 1 Single-Cell RNA sequencing |
Scott Yuzwa |
October 21, 2021 |
Neural Development I Technique 2 ATAC-seq Discussion of Final Assignment |
Scott Yuzwa (and potential guest lecturer) |
October 28, 2021 |
Neural Development II Technique 3 Genetic Clonal Labelling |
Scott Yuzwa |
November 4, 2021 |
Neural Stem Cells and their unique niche environments Technique 4 In Situ Spatial Labelling |
Scott Yuzwa |
November 11, 2021 |
Embryonic origins of Adult Neural Stem Cells Technique 5 Genetic Barcoding Strategies |
Scott Yuzwa |
November 18, 2021 |
Final Examination Concluding remarks: What does the future hold? |
Scott Yuzwa |