LMP1207H: Mass spectrometry, proteomics and their clinical applications

Who can attend

You must be registered in a graduate program to attend this course.

This course is open to all graduate students at the University of Toronto, provided you have pre-approval from your department and the course coordinators.

Course description

You will learn the fundamentals of mass spectrometry and its use with biochemical techniques to provide analyses of proteins and small molecules.

You will also study the interface with bioinformatics and other -omics technologies.

The second half of the course is designed to bridge the gap between basic and translational sciences and will examine the research and clinical applications of mass spectrometry.

Course coordinators

Dr. Vathany Kulasingam

vathany.kulasingam@uhn.ca

Dr. Lusia Sepiashvili

lusia.sepiashvili@sickkids.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every even year in the Fall term (i.e. 2020, 2022 etc).

Wednesdays 10 am – 12 pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Two written examinations:

  • Mid-term - 30%
  • Final exam - 30%

Presentation of a journal article - 20%

Take-home assignment - 20%

Schedule

Date

Topic

Lecturer/instructor

September 9, 2020

Introduction to mass spectrometry and proteomics

Dr. Vathany Kulasingam

September 16, 2020

Basic principles of mass spectrometry

Dr. Andrea Bozovic

September 23, 2020

Fundamentals of proteomics

Dr. Lusia Sepiashvili

September 30, 2020

Bioinformatics: Protein Identification and Targeted Proteomics

Dr. Vathany Kulasingam

October 7, 2020

Integration of proteomics with other -omics technologies

TBC

October 14, 2020

Mid-term exam

 

October 21, 2020

Post-translational modifications and Protein-protein interactions

TBC

October 28, 2020

Analytical workflows for sub-proteome analyses

Dr. Lusia Sepiashvili

November 4, 2020

Clinical microbiology and toxicology

Dr. Susan Poutanen

Dr. Stefan

November 11, 2020

Mass Spectrometry Imaging

Dr. Zarrine-Afsar

Medical Biophysics

November 18, 2020

Mass spectrometry for metabolic and molecular genetics

Dr. Lianna Kyriakopoulou

November 25, 2020

Emerging applications of Proteomics and MS

Dr. Vathany Kulasingam

Dr. Lusia Sepiashvili

December 2, 2020

Final examinations