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LMP1207H: Mass spectrometry, proteomics and their clinical applications

Who can attend

You must be registered in a graduate program to attend this course.

This course is open to all graduate students at the University of Toronto, provided you have pre-approval from your department and the course coordinators.

Course description

You will learn the fundamentals of mass spectrometry and its use with biochemical techniques to provide analyses of proteins and small molecules.

You will also study the interface with bioinformatics and other -omics technologies.

The second half of the course is designed to bridge the gap between basic and translational sciences and will examine the research and clinical applications of mass spectrometry.

Course coordinators

Dr. Lusia Sepiashvili

lusia.sepiashvili@sickkids.ca

Dr. Jessica Miller

jessica.miller@uhn.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every even year in the Fall term (i.e. 2024, 2026 etc).

Wednesdays 11 am – 1 pm

Location: TBD (Check Quercus course announcement)

Evaluation methods

Two written examinations:

  • Mid-term - 30%
  • Final exam - 30%

Presentation of a journal article - 20%

Take-home assignment - 20%

Schedule

Date

Topic

Lecturer/instructor

September 9, 2026

Introduction to mass spectrometry and proteomics

Dr. Lusia Sepiashvili

September 16, 2026

Basic principles of mass spectrometry

Dr. Jessica Miller

September 23, 2026

Fundamentals of proteomics

Dr. Lusia Sepiashvili

September 30, 2026

Protein Identification and Targeted Proteomics

Dr. Vathany Kulasingam & Dr. Annie Ren

October 7, 2026

Clinical toxicology

Dr. Jessica Miller

October 14, 2026

Global Metabolomics

Dr. Nikkita Looby

October 21, 2026

Mid-Term Exam

 

October 28, 2026

Analytical workflows for sub-proteome analyses

Dr. Wenk

November 4, 2026

November 11, 2026

Mass Spectrometry Imaging

Mass spectrometry for metabolic and molecular genetics

Dr. Zarrine-Afsar

Dr. Kyriakopoulou

November 18, 2026

Post-translational modifications and Protein-protein interactions

Dr. Kuzmanov

November 25, 2026

Integration of proteomics with other -omics technologies

Dr. Jurisica

December 2, 2026

Emerging applications of Proteomics and MS

Dr. Sepiashvili

December 9, 2026

Final Exam