LMP1207H: Mass spectrometry, proteomics and their clinical applications

Who can attend

You must be registered in a graduate program to attend this course.

This course is open to all graduate students at the University of Toronto, provided you have pre-approval from your department and the course coordinators.

Course description

You will learn the fundamentals of mass spectrometry and its use with biochemical techniques to provide analyses of proteins and small molecules.

You will also study the interface with bioinformatics and other -omics technologies.

The second half of the course is designed to bridge the gap between basic and translational sciences and will examine the research and clinical applications of mass spectrometry.

Course coordinators

Dr. Vathany Kulasingam

vathany.kulasingam@uhn.ca

Dr. Lusia Sepiashvili

lusia.sepiashvili@sickkids.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every even year in the Fall term (i.e. 2024, 2026 etc).

Wednesdays 10 am – 12 pm

Location: HS 618, Health Sciences Building 155 College Street, Toronto

Evaluation methods

Two written examinations:

  • Mid-term - 30%
  • Final exam - 30%

Presentation of a journal article - 20%

Take-home assignment - 20%

Schedule

Date

Topic

Lecturer/instructor

September 11, 2024

Introduction to mass spectrometry and proteomics

Dr. Vathany Kulasingam

September 18, 2024

Basic principles of mass spectrometry

Dr. Andrea Bozovic

September 25, 2024

Fundamentals of proteomics

Dr. Lusia Sepiashvili

October 2, 2024

Protein Identification and Targeted Proteomics

Dr. Vathany Kulasingam

October 9, 2024

Integration of proteomics with other -omics technologies

Dr. Voisin

October 16, 2024

Global Metabolomics

Dr. Nikkita Looby

October 19, 2022

Mid-Term Exam

 

October 23, 2024

Analytical workflows for sub-proteome analyses

Dr. Lusia Sepiashvili

October 30, 2024

Analytical workflows for sub-proteome analyses* *remote session; link to be provided

Dr. Wenk

November 6, 2024

November 13, 2024

Mass spectrometry for metabolic and molecular genetic

Mass Spectrometry Imaging

Dr. Kyriakopoulou

Dr. Zarrine-Afsar

November 20, 2024

Clinical toxicology

Dr. Stefan

November 27, 2024

Post-translational modifications and Protein-protein interactions

Dr. Kuzmanov

November 4, 2024

Emerging applications of Proteomics and MS

Dr. Sepiashvili

December 11, 2024

Final Exam