LMP410H1 - Pathobiology of Neurodegenerative Disease 24L

Course description

Focussing on the molecular basis of neurodegenerative diseases of the central and peripheral nervous systems.

We cover the molecular pathobiology of neurodegenerative diseases, current research developments, and writing research proposals.

You will practice the assembly of a succinct research proposal and query neurodegenerative disease material taught in the course in the mid-term and final exams.

Course coordinator

Dr. Gabor G. Kovacs

Office address: Krembil Discovery Tower, 60 Leonard Ave. Rm 6KD414


Teaching assistant

Marc Shenouda



Fall 2022

Class time

Wednesday 10:00 am - 12:00 pm

Tutorial time

December 7

Last day to drop course

November 16 (25% of final mark released before November 7)

Office hours

In-person meetings can be arranged with short notice.

Course details

  • Hours: 24 hrs = 10 lectures plus TA review, as well as mid-term and final exam
  • Prerequisite: BCH311H1/(PSL300H1, PSL301H1)
  • Exclusions: none
  • Breadth requirement: none
  • Enrolment limits: 35 students

Student evaluation

Mid-term: 25% for in-class component plus 25% for homework grant proposal

Final exam: 50% for neurodegenerative disease material test

See information on Academic Integrity



Topic and estimated time spent



September 14

Introduction to course and overview (2 hours)

Dr. Gabor Kovacs


September 21

Neuroanatomy / pathology (80 mins plus 30 min Q&A)

Dr. Forrest


September 28

Prion Diseases  (60 mins plus 20 min Q&A)

How to improve scientific writing in general (20 mins plus 10 min Q&A)

Dr. Gerold Schmitt-Ulms


October 5

Genetics (60 mins plus 20 min Q&A)

How to develop an introduction/rationale section for a project proposal (20 mins plus 10 min Q&A)

Dr. Ekaterina Rogaeva



October 12

Parkinson’s Disease (60 mins plus 20 min Q&A)

How to come up with a project title and write a significance section (20 mins plus 10 min Q&A)

Dr. Anurag Tandon



October 19

Tauopathies (60 mins plus 20 min Q&A)

How to generate a hypothesis and break a project into 2-3 specific aims (20 mins plus 10 min Q&A)

Dr. Joel Watts



October 26

ALS/FTD (60 mins plus 20 min Q&A)

How to write a concise work plan (20 mins plus 10 min Q&A)

Dr. Janice Robertson


November 2

Mid-term (2 hours)

Monitored by Teaching Assistant (TA)


November 7

Reading week November 8 - 12. No classes



November 16

Imaging and diagnostics (80 mins plus 30 min Q&A)

Dr. Carmela Tartaglia



November 23

Alzheimer’s disease (80 mins plus 30 min Q&A)

Dr. JoAnne McLaurin


November 30

Poly-glutamine disease (80 mins plus 30 min Q&A)

Dr. Park


December 7

Optional review of exam materials/study break (2 hours)

Teaching Assistant (TA)



Final exam (2 hours)

Monitored by Teaching Assistant (TA)


Recommended reading or text book

You are encouraged to familiarize yourself with software packages that automate the management and assembly of bibliographies (e.g., Endnote, Mendeley, Zotero, RefWorks).

The following is a list of useful resources (none of these are essential for this course but they should provide useful information and context):

Free online resources for general information on scientific writing

Books you can purchase:

  • The Chicago Guide to Communicating Science. Scott L. Montgomery. Published December 15th, 2002, by University Of Chicago Press. ISBN: 0226534855
  • Scientific and Medical Communication. Scott A. Mogull. Published April 8, 2016, by Routledge. ISBN: 1138842559.
  • Grant Writing in Higher Education: A Step‐by‐Step Guide. Kenneth T. Hensen. Published 2003 by Allyn & Bacon. ISBN‐13: 978‐0205389193