LMP420H1 – Cancer Pathogenesis

Course description

A general introduction to the cellular and molecular aspects of cancer and its etiology.

Topics include:

  • pathophysiology of cancer
  • invasion and metastases
  • role of the immune system
  • immune evasion
  • understanding biological targets
  • chemotherapeutic and immunotherapeutic agents and its mechanism of action
  • resistance mechanisms of cancer

Course coordinators

Dr. George Charames

Office address: Sinai Health, 700 University Ave, Room 8-400-6-3 

Dr. Paul Hamel

Office address: 1 King’s College Circle, MSB Rm 6316

Teaching assistant

Negar Khosraviani



Winter 2023

Lecture location and time

Thursday 9 - 11 am 

MY317 Myhal Centre MCEIE

55 St George Street

Tutorial location and time

Friday 12 - 1 pm

MSB 3278, Medical Sciences Building

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: LMP310H1
  • Exclusions: None
  • Recommended preparation: PCL386H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation


See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus




Lecture 1

Introduction: cancer research overview, terminology/cancer biology


Lecture 2

Epidemiology, DNA repair mechanisms


Lecture 3

BRCA in cancer


Lecture 4

Cancer invasion and metastasis


Lecture 5

Cancer metabolism


Lecture 6

Role of oxygen in normal and tumour biology


Lecture 7

Cancer biomarkers and personalized medicine


Lecture 8

Next generation sequencing and its application


Lecture 9

Cancer immune evasion


Lecture 10

Chemotherapeutics and immunotherapeutics


Lecture 11

Resistance mechanisms of cancer


Recommended reading or text book