LMP420H1 – Cancer Pathogenesis
Course description
A general introduction to the cellular and molecular aspects of cancer and its etiology.
Topics include:
- pathophysiology of cancer
- invasion and metastases
- role of the immune system
- immune evasion
- understanding biological targets
- chemotherapeutic and immunotherapeutic agents and its mechanism of action
- resistance mechanisms of cancer
Course coordinators
Office address: Sinai Health, 700 University Ave, Room 8-400-6-3
George.Charames@sinaihealth.ca
Office address: 1 King’s College Circle, MSB Rm 6316
paul.hamel@utoronto.ca
Teaching assistant
TBC
Term |
Winter 2023 |
Class location and time |
TBC |
Tutorial location and time |
TBC |
Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: LMP310H1
- Exclusions: None
- Recommended preparation: PCL386H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
TBC
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
Date |
Topic |
Instructor |
---|---|---|
Lecture 1 |
Introduction: cancer research overview, terminology/cancer biology |
|
Lecture 2 |
Epidemiology, DNA repair mechanisms |
|
Lecture 3 |
BRCA in cancer |
|
Lecture 4 |
Cancer invasion and metastasis |
|
Lecture 5 |
Cancer metabolism |
|
Lecture 6 |
Role of oxygen in normal and tumour biology |
|
Lecture 7 |
Cancer biomarkers and personalized medicine |
|
Lecture 8 |
Next generation sequencing and its application |
|
Lecture 9 |
Cancer immune evasion |
|
Lecture 10 |
Chemotherapeutics and immunotherapeutics |
|
Lecture 11 |
Resistance mechanisms of cancer |
|
Recommended reading or text book
None.