LMP420H1 – Cancer Pathogenesis

Course description

A general introduction to the cellular and molecular aspects of cancer and its etiology.

Topics include:

  • pathophysiology of cancer
  • invasion and metastases
  • role of the immune system
  • immune evasion
  • understanding biological targets
  • chemotherapeutic and immunotherapeutic agents and its mechanism of action
  • resistance mechanisms of cancer

Course coordinators

Dr. George Charames

Office address: Sinai Health, 700 University Ave, Room 8-400-6-3 
George.Charames@sinaihealth.ca

Dr. Paul Hamel

Office address: 1 King’s College Circle, MSB Rm 6316
paul.hamel@utoronto.ca

Teaching assistant

TBC

Term

Winter 2023

Class location and time

TBC

Tutorial location and time

TBC

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: LMP310H1
  • Exclusions: None
  • Recommended preparation: PCL386H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

TBC

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

Lecture 1

Introduction: cancer research overview, terminology/cancer biology

 

Lecture 2

Epidemiology, DNA repair mechanisms

 

Lecture 3

BRCA in cancer

 

Lecture 4

Cancer invasion and metastasis

 

Lecture 5

Cancer metabolism

 

Lecture 6

Role of oxygen in normal and tumour biology

 

Lecture 7

Cancer biomarkers and personalized medicine

 

Lecture 8

Next generation sequencing and its application

 

Lecture 9

Cancer immune evasion

 

Lecture 10

Chemotherapeutics and immunotherapeutics

 

Lecture 11

Resistance mechanisms of cancer

 

Recommended reading or text book

None.