LMP420H1 – Cancer Pathogenesis
Course description
A general introduction to the cellular and molecular aspects of cancer and its etiology.
Topics include:
- pathophysiology of cancer
- invasion and metastases
- role of the immune system
- immune evasion
- understanding biological targets
- chemotherapeutic and immunotherapeutic agents and its mechanism of action
- resistance mechanisms of cancer
Course coordinators
Office address: Sinai Health, 700 University Ave, Room 8-400-6-3
George.Charames@sinaihealth.ca
Office address: 1 King’s College Circle, MSB Rm 6316
paul.hamel@utoronto.ca
Teaching assistant
Negar Khosraviani
negar.khosraviani@mail.utoronto.ca
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Term |
Winter 2023 |
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Lecture location and time |
Thursday 9 - 11 am MY317 Myhal Centre MCEIE 55 St George Street |
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Tutorial location and time |
Friday 12 - 1 pm MSB 3278, Medical Sciences Building |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: LMP310H1
- Exclusions: None
- Recommended preparation: PCL386H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
TBC
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
|---|---|---|
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Lecture 1 |
Introduction: cancer research overview, terminology/cancer biology |
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Lecture 2 |
Epidemiology, DNA repair mechanisms |
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Lecture 3 |
BRCA in cancer |
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Lecture 4 |
Cancer invasion and metastasis |
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Lecture 5 |
Cancer metabolism |
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Lecture 6 |
Role of oxygen in normal and tumour biology |
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Lecture 7 |
Cancer biomarkers and personalized medicine |
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Lecture 8 |
Next generation sequencing and its application |
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Lecture 9 |
Cancer immune evasion |
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Lecture 10 |
Chemotherapeutics and immunotherapeutics |
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Lecture 11 |
Resistance mechanisms of cancer |
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Recommended reading or text book
None.