Making Sense of Senescence: Aging Through a Microscopic and Macroscopic Lens

11th LMPSU conference

Organised by the undergraduate students in the Department of Laboratory Medicine and Pathobiology, join us this January as we dive into some amazing research conducted by renowned scientists on the science of aging and senescence.

You can contact the LMPSU committee at lmpexecs@gmail.com.

Information for attendees

We are currently building the agenda for the conference so will update this page as we confirm details.

Who this conference is for

We welcome all interested learners, faculty and alumni from the University of Toronto.

Where and when it will take place

Saturday, January 14, 2023

9:30 am - 4 pm (breakfast and registration from 8:30 am)

MacLeod Auditorium

Medical Sciences Building
University of Toronto, Temerty Faculty of Medicine
1 King’s College Circle
Toronto, ON  M5S 1A8 Canada

Breakfast and lunch will be provided

Cost: none

Register now

The Agenda

8:30 – 9:30 Breakfast and registration

09:30 - 09:35 Welcome! Bonnie Yang and Britney Feng, LMPSU Co-Presidents

09:35 - 09:45 Opening remarks: Dr. Rita Kandel

09:45 - 10:25  Keynote speaker: Dr. Karim Mekhail "The nuclear lamina in genome stability, cellular senescence, and cancer"

10:25 - 11:05 Dr. Ekaterina Rogaeva

11:05 - 11:45 Dr. Lea Harrington

11:45 - 12:45 Lunch and poster fair (TBC) 

12:50 - 13:30 Dr. Tony Parks

13:30 - 14:10 Dr. Marc Grynpas

14:10 - 14:30 Break

14:30 - 15:50 Panel discussion

15:50 - 16:00 Closing remarks: Dr. Jeff Lee, Bonnie Yang and Britney Feng

Photography and videos

We will be taking photographs and recording some videos for departmental purposes. 

If you do not wish to be in any of the photos or videos, please make yourself known to the person taking pictures or videos.

Confirmed speaker biographies

Karim Mekhail

Dr. Karim Mekhail: Keynote speaker at 9:45 am

Prof. Karim Mekhail is a full professor of Laboratory Medicine and Pathobiology and a member of the Royal Society of Canada. He is an internationally renowned leader in nuclear organization and its roles in fundamental molecular processes, aging, and age-related diseases such as cancer and neurodegeneration.

He discovered seminal roles for the nuclear envelope in maintaining genome stability and showed how the alteration of such processes contributes to health and disease states. Amongst his seminal contributions is the discovery of nucleolar RNA polymerase II, the directional movement of DNA, the first molecular DNA ambulance, DNA repair by liquid-like proteins, novel therapeutic targets for breast and ovarian cancer control, and the functions of genes linked with several neurodegenerative disorders.

His laboratory relies on multidisciplinary tools at the intersection of molecular biology, engineering, and bioinformatic approaches applied within different experimental systems, including human cells, patient samples, and mouse and yeast genetic models.

Dr. Mekhail's faculty profile

Ekaterina Rogaeva

Dr. Ekaterina Rogaeva: speaking at 10:45 am

Dr. Rogaeva’s graduate degree (1983) and PhD in Biochemistry (1988) were obtained at Moscow State University.

For the past 30 years, she has been doing genetic research at the University of Toronto in Tanz Centre for Research in Neurodegenerative Diseases. In 2001, Dr. Rogaeva obtained the New Pioneer Award from the Ontario government in the Science and Technology category. In 2013, she obtained the Lewy Body Chair position, and was promoted to Full Professor in 2015.

Dr. Rogaeva contributed to 393 peer-reviewed papers (h-index=91). Most of these papers are focused on the development of effective genetic testing of neurodegenerative diseases (eg, Alzheimer’s Disease, amyotrophic lateral sclerosis and Parkinson’s Disease). For instance, she played a central role in the discovery of several genes associated with Alzheimer’s Disease (eg, PSEN1, PSEN2 and SORL1).

More recently, Dr. Rogaeva's studies are focused on the link between neurodegenerative disorders and epigenetic events, such as age-related DNA methylation reflecting the biological aging. 

Marc Grynpas

Dr. Marc Grynpas: speaking at 1:30 pm

Marc Grynpas, PhD, is a professor in the Department of Laboratory Medicine and Pathobiology and a member of the Institute for Biomedical Engineering at the University of Toronto. He is also a Senior Scientist at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital. He is the Director of the Bone and Mineral Research Group at the University of Toronto.

Dr. Grynpas graduated from the Free University of Brussels with an undergraduate degree in Physics. At the University of London, he completed his Ph.D. in Crystallography and Biophysics on the structure of bone. After a post-doctoral fellowship at Queen Mary College (University of London) on the relationship between bone structure and bone mechanical properties, he joined the laboratory of Professor Melvin Glimcher at the Children’s Hospital in Boston (Harvard Medical School) where he worked on the nature of the bone mineral.

His research laboratory is located at The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto. He has published over 260 refereed papers, 26 book chapters, and proceedings and is currently holding 5 patents.

Dr. Marc Grynpas’ research focuses on the structure, chemistry, and biology of the skeleton. His work covers basic research on biological mineralization to translational research on bone fragility in osteoporosis. More specifically, he is trying to understand the mechanisms, which lead to bone fragility in osteoporosis and joint degeneration in arthritis. Using animal models, he is investigating the determinants of bone quality. He is also working together with colleagues on new biomaterials and conjugated drugs to regenerate bone.

Dr. Grynpas' faculty profile