LMP450H1 – Organogenesis in Health and Disease
Course description
This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.
We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.
This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.
Course coordinators
Office address: UHN, 101 College St, TDMT, Rm 3-908
michael.laflamme@uhnresearch.ca
Office address: UHN 101 College St, TDMT, Rm 8-701
Shinichiro.Ogawa@uhnresearch.ca
Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca
Teaching assistant
Justin Callahan
|
Term |
Fall 2023 |
|
Lecture time |
Friday 10 am - 12 pm |
|
Tutorial time |
Friday 12 - 1 pm |
|
Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: LMP320H1, LMP330H1
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
|
Title |
Description |
Percentage |
|---|---|---|
|
Midterm Exam |
|
30% |
|
Oral Presentations |
|
40% |
|
Final Examination |
Short-answer with choice of questions to answer.
|
30% |
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
|
Date |
Lecture hour 1: 10:10 - 11 am |
Lecture hour 2: 11:10 am - 12 pm |
|---|---|---|
|
September 8, 2023 |
Introduction to stem cells |
Stem cell paper presented by faculty |
|
September 15, 2023 |
Applications employing stem cells |
Stem cell paper presented by faculty |
|
September 22, 2023 |
Tissue patterning and organ development |
Stem cell paper presented by faculty |
|
September 29, 2023 |
Intestinal organoids |
Hepatic and pancreatic organoids |
|
October 6, 2023 |
Midterm Examination |
|
|
October 13, 2023 |
Cerebral organoids and organogenesis |
Cancer organoids |
|
October 20, 2023 |
Kidney/lung organoids |
Cardiac organoids |
|
October 27, 2023 |
Organogenesis: engineering organs |
Approach to dissecting a manuscript/ In-class journal club prep |
|
November 3, 2023 |
Immune organoids Guest lecturer Dr. Julien Muffat |
In-class journal club prep All faculty |
|
November 10, 2023 |
Reading Week, no classes |
|
|
November 17, 2023 |
Student Oral Presentations All faculty |
|
|
November 25 |
Student Oral Presentations All faculty |
|
|
December 2 |
Student Oral Presentations All faculty |
Course Review All faculty |
Recommended reading or text book
None.