LMP450H1 – Organogenesis in Health and Disease

Course description

This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.

We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.

This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.

Course coordinators

Dr. Michael Laflamme

Office address: UHN, 101 College St, TDMT, Rm 3-908
michael.laflamme@uhnresearch.ca

Dr. Shinichiro Ogawa

Office address: UHN 101 College St, TDMT, Rm 8-701
Shinichiro.Ogawa@uhnresearch.ca

Dr. Karun Singh

Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca

Teaching assistant

TBC

Term

Fall 2022

Class location and time

TBC

Tutorial location and time

 

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: LMP320H1, LMP330H1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

TBC 

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

Lecture 1

Introduction to stem cells

 

Lecture 2

Applications employing stem cells

 

Lecture 3

Tissue patterning and organ development

 

Lecture 4

Intestinal organoids

 

Lecture 5

Hepatic and pancreatic organoids

 

Lecture 6

Cerebral organoids and organogenesis

 

Lecture 7

Cancer organoids

 

Lecture 8

Lung organoids

 

Lecture 9

Organogenesis: engineering organs

 

Lecture 10

Organogenesis: reconstituting decellularized organs

 

Lecture 11

Small group activity

 

Lecture 12

Small group presentation

 

Recommended reading or text book

None.