LMP450H1 – Organogenesis in Health and Disease

Course description

This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.

We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.

This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.

Course coordinators

Dr. Michael Laflamme

Office address: UHN, 101 College St, TDMT, Rm 3-908
michael.laflamme@uhnresearch.ca

Dr. Shinichiro Ogawa

Office address: UHN 101 College St, TDMT, Rm 8-701
Shinichiro.Ogawa@uhnresearch.ca

Dr. Karun Singh

Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca

Teaching assistant

TBC

Term	Fall 2022
Class location and time	TBC
Tutorial location and time
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite: LMP320H1, LMP330H1
Exclusions: None
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

TBC

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
Lecture 1	Introduction to stem cells
Lecture 2	Applications employing stem cells
Lecture 3	Tissue patterning and organ development
Lecture 4	Intestinal organoids
Lecture 5	Hepatic and pancreatic organoids
Lecture 6	Cerebral organoids and organogenesis
Lecture 7	Cancer organoids
Lecture 8	Lung organoids
Lecture 9	Organogenesis: engineering organs
Lecture 10	Organogenesis: reconstituting decellularized organs
Lecture 11	Small group activity
Lecture 12	Small group presentation