LMP450H1 – Organogenesis in Health and Disease
Course description
This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.
We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.
This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.
Course coordinators
Office address: UHN, 101 College St, TDMT, Rm 3-908
michael.laflamme@uhnresearch.ca
Office address: UHN 101 College St, TDMT, Rm 8-701
Shinichiro.Ogawa@uhnresearch.ca
Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca
Teaching assistant
TBC
Term |
Fall 2022 |
Class location and time |
TBC |
Tutorial location and time |
|
Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: LMP320H1, LMP330H1
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
TBC
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
Date |
Topic |
Instructor |
---|---|---|
Lecture 1 |
Introduction to stem cells |
|
Lecture 2 |
Applications employing stem cells |
|
Lecture 3 |
Tissue patterning and organ development |
|
Lecture 4 |
Intestinal organoids |
|
Lecture 5 |
Hepatic and pancreatic organoids |
|
Lecture 6 |
Cerebral organoids and organogenesis |
|
Lecture 7 |
Cancer organoids |
|
Lecture 8 |
Lung organoids |
|
Lecture 9 |
Organogenesis: engineering organs |
|
Lecture 10 |
Organogenesis: reconstituting decellularized organs |
|
Lecture 11 |
Small group activity |
|
Lecture 12 |
Small group presentation |
|
Recommended reading or text book
None.