LMP450H1 – Organogenesis in Health and Disease
Course description
This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.
We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.
This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.
Course coordinators
Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca
Office address: TMDT/ MaRS, 101 College St, Rm 3-908
michael.laflamme@uhnresearch.ca
Office address: McEwen Stem Cell Institute, 101 College St., MaRS Centre / PMCRT 8-701
shinichiro.ogawa@uhnresearch.ca
Teaching assistant
Britney Tian
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Term |
Fall 2025 |
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Lecture time |
Friday 9 - 11 am |
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Tutorial time |
Friday 11 am - 12 pm |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: LMP320H1, LMP330H1. Pre-requisite waiver requests must be made to the academic unit (lmp.undergraduate@utoronto.ca).
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
30% - Midterm - 3 October, 2025
40% - Group oral presentation - This will include preparing a slide deck with group members, oral presentation of the scientific paper, and answering questions (orally).
30% - Final exam
See information on Academic Integrity
Late Assessment Policy
A penalty of 5% will be deducted if late
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Lecture hour 1: 10:10 - 11 am |
Lecture hour 2: 11:10 am - 12 pm |
|---|---|---|
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September 5, 2025 |
Introduction to stem cells |
Stem cell paper presented by faculty |
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September 12, 2025 |
Applications employing stem cells |
Tissue patterning and organ development |
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September 19, 2025 |
Kidney/lung organoids |
Stem cell paper presented by faculty |
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September 26, 2025 |
Cerebral organoids and organogenesis |
Stem cell paper presented by faculty |
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October 3, 2025 |
Midterm Examination |
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October 10, 2025 |
Cardiac organoids |
Cancer organoids |
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October 17, 2025 |
Hepatic and pancreatic organoids |
Intestinal organoids |
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October 24, 2025 |
Organogenesis and engineering organs |
Approach to journal club presentation tips; in-class prep |
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October 31, 2025 |
Reading week: no classes |
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November 7, 2025 |
Macrophages and immune cells in organoids Guest lecturer Dr. Epelman |
Course review
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November 14, 2025 |
Student oral presentations All faculty |
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November 21, 2025 |
Student oral presentations All faculty |
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November 28, 2025 |
Student oral presentations All faculty |
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Recommended reading or text book
None.