LMP450H1 – Organogenesis in Health and Disease

Course description

This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.

We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.

This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.

Course coordinators

Dr. Michael Laflamme

Office address: UHN, 101 College St, TDMT, Rm 3-908
michael.laflamme@uhnresearch.ca

Dr. Shinichiro Ogawa

Office address: UHN 101 College St, TDMT, Rm 8-701
Shinichiro.Ogawa@uhnresearch.ca

Dr. Karun Singh

Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca

Teaching assistant

Justin Callahan

jd.callahan@mail.utoronto.ca

Term	Fall 2022
Lecture location and time	Friday 10 am - 12 pm UC A101, University College, 15 King’s College Circle
Tutorial location and time	Friday 12 - 1 pm UC A101, University College, 15 King’s College Circle
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite: LMP320H1, LMP330H1
Exclusions: None
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

Title	Description	Percentage
Midterm Exam	Short-answer with choice of questions to answer Will cover lecture and faculty paper presentations from September 9-30	30%
Oral Presentations	Groups of 3-4 students will collaborate to critically evaluate and present a scientific paper relevant to stem cells, organoids, or organogenesis Papers will be selected from a bank of publications to be provided by faculty	40%
Final Examination	Short-answer with choice of questions to answer Will cover lecture and faculty/student paper presentations from October 14-December 2 Any questions pertaining to student presentations will be high-level content (e.g. not methodological details)	30%

Title

Description

Percentage

Midterm Exam

Short-answer with choice of questions to answer
Will cover lecture and faculty paper presentations from September 9-30

30%

Oral Presentations

Groups of 3-4 students will collaborate to critically evaluate and present a scientific paper relevant to stem cells, organoids, or organogenesis
Papers will be selected from a bank of publications to be provided by faculty

40%

Final Examination

Short-answer with choice of questions to answer
Will cover lecture and faculty/student paper presentations from October 14-December 2

Any questions pertaining to student presentations will be high-level content (e.g. not methodological details)

30%

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
September 9	Introduction to stem cells Stem cell paper presented by faculty	Dr. Karun Singh
September 16	Applications employing stem cells Stem cell paper presented by faculty	Dr. Karun Singh Dr. Shinichiro Ogawa
September 23	Tissue patterning and organ development Stem cell paper presented by faculty	Dr. Shinichiro Ogawa Dr. Michael Laflamme
September 30	Intestinal organoids Hepatic and pancreatic organoids	Dr. Shinichiro Ogawa
October 7	Midterm Examination	All faculty
October 14	Cerebral organoids and organogenesis Cancer organoids	Dr. Karun Singh Dr. Shinichiro Ogawa
October 21	Kidney/Lung organoids Cardiac organoids	Dr. Shinichiro Ogawa Dr. Michael Laflamme
October 28	Organogenesis: engineering organs Approach to dissecting a manuscript/ In-class journal club prep	Dr. Michael Laflamme
November 4	In-class journal club prep	All faculty
November 11	Reading Week	All faculty
November 18	Student Oral Presentations	All faculty
November 25	Student Oral Presentations	All faculty
December 2	Student Oral Presentations Course Review	All faculty