LMP450H1 – Organogenesis in Health and Disease

Course description

This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.

We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.

This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.

Course coordinators

Dr. Michael Laflamme

Office address: UHN, 101 College St, TDMT, Rm 3-908

Dr. Shinichiro Ogawa

Office address: UHN 101 College St, TDMT, Rm 8-701

Dr. Karun Singh

Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417

Teaching assistant

Justin Callahan



Fall 2023

Lecture time

Friday 10 am - 12 pm

Tutorial time

Friday 12 - 1 pm

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: LMP320H1, LMP330H1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation




Midterm Exam

  • Short-answer with choice of questions to answer

  • Will cover lecture and faculty paper presentations from September 8 - 29


Oral Presentations

  • Groups of 3 - 4 students will collaborate to critically evaluate and present a scientific paper relevant to stem cells, organoids, or organogenesis

  • Papers will be selected from a bank of publications to be provided by faculty


Final Examination

Short-answer with choice of questions to answer.

  • Will cover lecture and faculty/student paper presentations from October 13 - December 1

  • Any questions pertaining to student presentations will be high-level content (e.g. not methodological details) 


See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus


Lecture hour 1: 10:10 - 11 am

Lecture hour 2: 11:10 am - 12 pm

September 8, 2023

Introduction to stem cells

Dr. Karun Singh

Stem cell paper presented by faculty

Dr. Karun Singh

September 15, 2023

Applications employing stem cells

Dr. Karun Singh

Stem cell paper presented by faculty

Dr. Michael Laflamme

September 22, 2023

Tissue patterning and organ development

Dr. Shinichiro Ogawa

Stem cell paper presented by faculty

Dr. Shinichiro Ogawa

September 29, 2023

Intestinal organoids

Dr. Shinichiro Ogawa

Hepatic and pancreatic organoids

Dr. Shinichiro Ogawa

October 6, 2023

Midterm Examination


October 13, 2023

Cerebral organoids and organogenesis

Dr. Karun Singh

Cancer organoids

Dr. Karun Singh

Dr. Shinichiro Ogawa

October 20, 2023

Kidney/lung organoids

Dr. Shinichiro Ogawa

Dr. Michael Laflamme

Cardiac organoids

Dr. Michael Laflamme

October 27, 2023

Organogenesis: engineering organs

Dr. Michael Laflamme

Approach to dissecting a manuscript/ In-class journal club prep

Dr. Michael Laflamme

November 3, 2023

Immune organoids

Guest lecturer Dr. Julien Muffat

In-class journal club prep 

All faculty

November 10, 2023

Reading Week, no classes


November 17, 2023

Student Oral Presentations

All faculty


November 25

Student Oral Presentations

All faculty


December 2

Student Oral Presentations

All faculty

Course Review

All faculty

Recommended reading or text book