LMP1200H: Neoplasia

Who can attend

MSc or PhD students with background in molecular biology, cell biology and/or biochemistry.

Course description

This is an advanced, seminar-based course designed to provide an in-depth examination of the molecular and cellular mechanisms that contribute to malignant transformation.

You will learn:

  • the role of glycolysis in the regulation of growth factor signaling
  • mechanisms through which glycolytic enzymes/metabolites regulate chromatin modifications
  • epigenetic mechanisms that influence epithelial/mesenchymal transition
  • cancer pathogenesis.

These mechanisms will be used as the basis to discuss neoplasia in specific model tissues.

You will develop analytical and critical thinking skills and an understanding of the interplay of metabolism, epigenetics and tumorigenesis.

Structure

This class is structured as a journal club.

Each week a paper will be presented by one student:

  • 60-minute presentation, and
  • approximately 60-minute discussion.

If you are not presenting, you are expected to contribute to the discussions.

Course coordinator

Dr. Maria Rozakis Adcock

maria.rozakis@utoronto.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

Thursdays, 10:00am-12:30pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Oral presentations of assigned papers - 50%

You will present two original papers.

The coordinator will assess your presentations.

Participation in discussions - 20%

You are expected to actively participate in discussions when you are not presenting.

The coordinator will allocate specific students to review each research paper and come to class with prepared questions.

The quality of the questions and answers will be evaluated and marked.

Research Proposals - 30%

You will write a research proposal unrelated to your current area of investigation, or area of investigation in your supervisor’s lab.

You will write this proposal in a typical grant style - maximum five pages long, single spaced excluding references and figures.

Schedule

All seminars are run by Dr. Rozakis Adcock.

Date

Topic

January 21, 2021

Introduction

Session 1: Epigenetics, Bromodomains and stem cell plasticity

January 28, 2021

Bromodomain Proteins in Basal-like Breast Cancer

February 4, 2021

Functional interaction of EMT factors and Glycolytic Enzymes, in imparting Metabolic Advantages in Breast Cancer

February 11, 2021

Functional interdependence of BRD proteins and Methyltransferases in MLL leukemia

February 18, 2021

Chromatin Configuration at EMT-TF promoters and cancer stem cell plasticity

Session 2: Cancer metabolism

February 25, 2021

Hexokinases in Tumor Initiation and Maintenance

March 4, 2021

Pyruvate Kinase regulation of Histone H3 modifications

March 11, 2021

MYC/PGC-1a Role in Determining the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

March 18, 2021

mTOR Complex 2 Control of Glycolytic Metabolism in Glioblastomas

Session 3: Diabetes and cancer

March 25, 2021

Contribution of Adipocytes in promoting ovarian cancer metastasis

April 1, 2021

Influence of lipogenic transcriptional networks in metastatic prostate cancer

April 8, 2021

Hyperglycemia impact on TET DNA methylation reveals networks linking diabetes to cancer

April 15, 2021

Grant Proposal due date