LMP320H1 – Pathobiology of Stem Cells
Course description
Enrolment is limited to students in the Pathobiology specialist program.
This course introduces stem cells and their impact on human health and disease.
You will study stem cells from the perspective of development and disease, with a focus on the nervous system, respiratory system and cancer.
This course is intended to provide a foundation in the basis of stem cells in preparation for fourth-year courses.
Course coordinators
Office address: St. Michael’s Hospital, 30 Bond St
sunit.das@utoronto.ca
Office address: SickKids, 686 Bay St, PGCRL Rm 17-904
apwong@sickkids.ca
Office address: 1 King’s College Circle, MSB Rm 6336
scott.yuzwa@utoronto.ca
Teaching assistant
TBC
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Term |
Winter 2023 |
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Class location and time |
TBC |
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Tutorial location and time |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program.
- Prerequisite: LMP200H1
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
- Assignments/Essay/Paper: 15%
- Quiz #1: 20%
- Quiz #2: 20%
- In-class participation/discussion: 5%
- Final Exam: 40%
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
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Stem cells in the pathobiology of the nervous system |
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Lecture 1 |
Introduction to stem cells and stem cell biology |
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Lecture 2 |
Stem cells build tissues: focus on the brain and nervous system |
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Lecture 3 |
Neural stem cells (NSCs) in the adult brain and nervous system |
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Lecture 4 |
NSCs and disease: focus on NSC responses to stroke and demyelination |
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Stem cells in the pathobiology of the respiratory system |
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Lecture 5 |
Stem cells in lung development |
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Lecture 6 |
Endogenous stem cells of the lung: role in homeostasis and repair |
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Lecture 7 |
Non-pulmonary stem cell treatment of congenital pulmonary diseases |
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Lecture 8 |
Modeling human cystic fibrosis and respiratory virus lung diseases using stem cells |
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Stem cells and cancer |
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Lecture 9 |
From clones to hierarchies: the clonal evolution model versus the cancer stem cell hypothesis |
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Lecture 10 |
Understanding cancer through normal physiology: the story of AML |
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Lecture 11 |
Understanding the cell-of-origin and oncologic risk in the context of brain development: a tale of three brain tumors |
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Lecture 12 |
Finding the cancer stem cell: challenges and complications |
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Recommended reading or text book
None.