LMP320H1 – Pathobiology of Stem Cells

Course description

Enrolment is limited to students in the Pathobiology specialist program.

This course introduces stem cells and their impact on human health and disease.

You will study stem cells from the perspective of development and disease, with a focus on the nervous system, respiratory system and cancer.

This course is intended to provide a foundation in the basis of stem cells in preparation for fourth-year courses.

Course coordinators

Dr. Sunit Das

Office address: St. Michael’s Hospital, 30 Bond St
sunit.das@utoronto.ca

Dr. Amy Wong

Office address: SickKids, 686 Bay St, PGCRL Rm 17-904
apwong@sickkids.ca

Dr. Scott Yuzwa

Office address: 1 King’s College Circle, MSB Rm 6336 
scott.yuzwa@utoronto.ca

Teaching assistant

TBC

Term

Winter 2023

Class location and time

TBC

Tutorial location and time

 

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program.
  • Prerequisite: LMP200H1
  • Exclusions: None
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation

  • Assignments/Essay/Paper: 15%
  • Quiz #1: 20%
  • Quiz #2: 20%
  • In-class participation/discussion: 5%
  • Final Exam: 40%

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

 

Stem cells in the pathobiology of the nervous system

 

Lecture 1

Introduction to stem cells and stem cell biology

 

Lecture 2

Stem cells build tissues: focus on the brain and nervous system

 

Lecture 3

Neural stem cells (NSCs) in the adult brain and nervous system

 

Lecture 4

NSCs and disease: focus on NSC responses to stroke and demyelination

 

 

Stem cells in the pathobiology of the respiratory system

 

Lecture 5

Stem cells in lung development

 

Lecture 6

Endogenous stem cells of the lung: role in homeostasis and repair

 

Lecture 7

Non-pulmonary stem cell treatment of congenital pulmonary diseases

 

Lecture 8

Modeling human cystic fibrosis and respiratory virus lung diseases using stem cells

 

 

Stem cells and cancer

Lecture 9

From clones to hierarchies: the clonal evolution model versus the cancer stem cell hypothesis

 

Lecture 10

Understanding cancer through normal physiology: the story of AML

 

Lecture 11

Understanding the cell-of-origin and oncologic risk in the context of brain development: a tale of three brain tumors

 

Lecture 12

Finding the cancer stem cell: challenges and complications

 

Recommended reading or text book

None.