LMP320H1 – Pathobiology of Stem Cells

Course description

Enrolment is limited to students in the Pathobiology specialist program.

This course introduces stem cells and their impact on human health and disease.

You will study stem cells from the perspective of development and disease, with a focus on the nervous system, respiratory system and cancer.

This course is intended to provide a foundation in the basis of stem cells in preparation for fourth-year courses.

Office address: St. Michael’s Hospital, 30 Bond St
sunit.das@utoronto.ca

Office address: SickKids, 686 Bay St, PGCRL Rm 17-904
apwong@sickkids.ca

Office address: 1 King’s College Circle, MSB Rm 6336
scott.yuzwa@utoronto.ca

Polina Balin

Term	Winter 2023
Lecture location and time	Tuesday 9 - 11 am Room OA 402 at 263 McCaul 263 McCaul is located just south of College Street on the east side, behind the Health Sciences Building (155 College St).
Tutorial location and time	Tuesday 11 am - 12 pm Room OA 402 at 263 McCaul
Office hours	Contact TA or Course Coordinators

Hours: 24L/12T
Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program.
Prerequisite: LMP200H1
Exclusions: None
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 35 students

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
	Stem cells in the pathobiology of the nervous system
Lecture 1	Introduction to stem cells and stem cell biology
Lecture 2	Stem cells build tissues: focus on the brain and nervous system
Lecture 3	Neural stem cells (NSCs) in the adult brain and nervous system
Lecture 4	NSCs and disease: focus on NSC responses to stroke and demyelination
	Stem cells in the pathobiology of the respiratory system
Lecture 5	Stem cells in lung development
Lecture 6	Endogenous stem cells of the lung: role in homeostasis and repair
Lecture 7	Non-pulmonary stem cell treatment of congenital pulmonary diseases
Lecture 8	Modeling human cystic fibrosis and respiratory virus lung diseases using stem cells
	Stem cells and cancer
Lecture 9	From clones to hierarchies: the clonal evolution model versus the cancer stem cell hypothesis
Lecture 10	Understanding cancer through normal physiology: the story of AML
Lecture 11	Understanding the cell-of-origin and oncologic risk in the context of brain development: a tale of three brain tumors
Lecture 12	Finding the cancer stem cell: challenges and complications