LMP430H1 – Metabolic disorders
Course description
This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.
You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.
Course coordinators
Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710
hoon-ki.sung@sickkids.ca
Office address: Sinai Health Systems, 600 University Ave
jennifer.taher@sinaihealth.ca
Office address: SickKids, 555 University Ave, Roy C Hill Wing
libin.yuan@sickkids.ca
Teaching assistant
Danielle Alvares
danielle.alvares@mail.utoronto.ca
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Term |
Winter 2023 |
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Lecture location and time |
Thursday 1 - 3 pm PB 255, Leslie Dan Pharmacy Building |
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Tutorial location and time |
Thursday 3 - 4 pm PB 255, Leslie Dan Pharmacy Building |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: BCH210H1, PSL300H1
- Exclusions: None
- Recommended preparation: PSL425H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Midterm test: 40%
Participation: 10%
Final exam: 50%
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
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Metabolism |
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Lecture 1 |
Energy Homeostasis and Metabolic Regulation 1 - General overview and introduction of major metabolic organs |
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Lecture 2 |
Energy Homeostasis and Metabolic Regulation 2 - Pathobiology of metabolic regulation in the brain, muscle, adipose tissue, kidney and liver |
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Lecture 3 |
Metabolic Analysis and Phenotyping 1 - In vivo metabolic analysis, phenotyping and clinical translation |
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Lecture 4 |
Metabolic Analysis and Phenotyping 2 - Histopathology and biochemical analysis for phenotyping and diagnosis |
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Lipids and dyslipidemia |
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Lecture 5 |
Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia) |
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Lecture 6 |
Disorders leading to dysglycemia |
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Lecture 7 |
Analytical principles of lipids, lipoproteins and glycemic control testing |
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Aminoacidopathies and lysosomal storage disorders |
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Lecture 8 |
Inborn errors of metabolism (aminoacidopathies) |
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Lecture 9 |
Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias) |
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Lecture 10 |
Inborn errors of metabolism (lysosomal storage disorders 1) |
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Lecture 11 |
Inborn errors of metabolism (lysosomal storage disorders 2) |
Recommended reading or text book
None.