LMP430H1 – Metabolic disorders

Course description

This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.

You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.

Course coordinators

Dr. Hoon-Ki Sung

Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710 

Dr. Jennifer Taher

Office address: Sinai Health Systems, 600 University Ave

Dr. Libin Yuan

Office address: SickKids, 555 University Ave, Roy C Hill Wing

Teaching assistant

Luxcia Kugathasan



Winter 2024

Lecture time

Thursday 1 - 3 pm

Tutorial time

Thursday 3 - 4 pm

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: BCH210H1, PSL300H1
  • Exclusions: None
  • Recommended preparation: PSL425H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 30 students

Student evaluation

Group presentation (Lectures 1,2, and 3): 20% (February 2)

Midterm test (Lectures 1-5): 20% (February 16)

Participation: 10%

Final exam (Lectures 6-11): 50% (Timing TBD)

See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus







January 12, 2023

Energy Homeostasis and metabolic regulation:

  • General overview of metabolism and metabolic disease
  • Physiological role of metabolic organs and their pathobiology (adipose and liver)

Dr. Hoon-Ki Sung

January 19, 2023

Metabolic function of major metabolic organs:

  • Physiological role of metabolic organs and their pathobiology (muscle and other organs)
  • In vivo metabolic analysis, phenotyping, and clinical translation

Dr. Hoon-Ki Sung

January 26, 2023

Metabolic Analysis and Phenotyping 1 - In vivo metabolic analysis, phenotyping and clinical translation

Dr. Hoon-Ki Sung

February 2, 2023

Metabolic phenotyping and diet intervention of metabolic disease:

  • Metabolic phenotyping and clinical translation
  • Therapeutic approaches for metabolic diseases and the impact of diet interventions

Dr. Hoon-Ki Sung


Lipids and dyslipidemia


February 9, 2023

Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia)

Dr. Jennifer Taher

February 16, 2023

Midterm exam covering material from Lectures 1 - 5


February 23, 2023

Reading Week (no class)


March 2, 2023

Disorders leading to dysglycemia

Dr. Jennifer Taher

March 9, 2023

Analytical principles of lipids, lipoproteins and glycemic control testing

Dr. Jennifer Taher


Aminoacidopathies and lysosomal storage disorders 


March 16, 2023

Inborn errors of metabolism (aminoacidopathies) 

Dr. Libin Yuan

March 23, 2023

Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias)

Dr. Libin Yuan

March 30, 2023

Inborn errors of metabolism (lysosomal storage disorders 1)

Dr. Libin Yuan

April 6, 2023

Inborn errors of metabolism (lysosomal storage disorders 2) 

Dr. Libin Yuan


Final exam covering lectures 6 - 11


Recommended reading or text book