LMP430H1 – Metabolic disorders

Course description

This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.

You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.

Course coordinators

Dr. Hoon-Ki Sung

Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710
hoon-ki.sung@sickkids.ca

Dr. Jennifer Taher

Office address: Sinai Health Systems, 600 University Ave
jennifer.taher@sinaihealth.ca

Dr. Libin Yuan

Office address: SickKids, 555 University Ave, Roy C Hill Wing
libin.yuan@sickkids.ca

Teaching assistant

Luxcia Kugathasan

l.kugathasan@mail.utoronto.ca

Term	Winter 2024
Lecture time	Thursday 1 - 3 pm
Tutorial time	Thursday 3 - 4 pm
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite: BCH210H1, PSL300H1
Exclusions: None
Recommended preparation: PSL425H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

Group presentation (Lectures 1,2, and 3): 20% (February 2)

Midterm test (Lectures 1-5): 20% (February 16)

Participation: 10%

Final exam (Lectures 6-11): 50% (Timing TBD)

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
	Metabolism
January 12, 2023	Energy Homeostasis and metabolic regulation: General overview of metabolism and metabolic disease Physiological role of metabolic organs and their pathobiology (adipose and liver)	Dr. Hoon-Ki Sung
January 19, 2023	Metabolic function of major metabolic organs: Physiological role of metabolic organs and their pathobiology (muscle and other organs) In vivo metabolic analysis, phenotyping, and clinical translation	Dr. Hoon-Ki Sung
January 26, 2023	Metabolic Analysis and Phenotyping 1 - In vivo metabolic analysis, phenotyping and clinical translation	Dr. Hoon-Ki Sung
February 2, 2023	Metabolic phenotyping and diet intervention of metabolic disease: Metabolic phenotyping and clinical translation Therapeutic approaches for metabolic diseases and the impact of diet interventions	Dr. Hoon-Ki Sung
	Lipids and dyslipidemia
February 9, 2023	Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia)	Dr. Jennifer Taher
February 16, 2023	Midterm exam covering material from Lectures 1 - 5
February 23, 2023	Reading Week (no class)
March 2, 2023	Disorders leading to dysglycemia	Dr. Jennifer Taher
March 9, 2023	Analytical principles of lipids, lipoproteins and glycemic control testing	Dr. Jennifer Taher
	Aminoacidopathies and lysosomal storage disorders
March 16, 2023	Inborn errors of metabolism (aminoacidopathies)	Dr. Libin Yuan
March 23, 2023	Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias)	Dr. Libin Yuan
March 30, 2023	Inborn errors of metabolism (lysosomal storage disorders 1)	Dr. Libin Yuan
April 6, 2023	Inborn errors of metabolism (lysosomal storage disorders 2)	Dr. Libin Yuan
TBC	Final exam covering lectures 6 - 11