LMP430H1 – Metabolic disorders

Course description

This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.

You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.

Course coordinators

Dr. Hoon-Ki Sung

Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710
hoon-ki.sung@sickkids.ca

Dr. Jennifer Taher

Office address: Sinai Health Systems, 600 University Ave
jennifer.taher@sinaihealth.ca

Dr. Libin Yuan

Office address: SickKids, 555 University Ave, Roy C Hill Wing
libin.yuan@sickkids.ca

Teaching assistant

Luxcia Kugathasan

l.kugathasan@mail.utoronto.ca

Term	Winter 2024
Lecture time	Thursday 1 - 3 pm
Tutorial time	Thursday 3 - 4 pm
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite: BCH210H1, PSL300H1
Exclusions: None
Recommended preparation: PSL425H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

Group presentation (Lectures 1,2, and 3): 20% (February 1)

Midterm test (Lectures 1-5): 20% (February 15)

Participation: 10%

Final exam (Lectures 6-11): 50% (Timing TBD)

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Topic	Instructor
	Metabolism
January 11, 2024	Energy Homeostasis and metabolic regulation: General overview of metabolism and metabolic disease Physiological role of metabolic organs and their pathobiology (adipose and liver)	Dr. Hoon-Ki Sung
January 18, 2024	Metabolic function of major metabolic organs: Physiological role of metabolic organs and their pathobiology (muscle and other organs) In vivo metabolic analysis, phenotyping, and clinical translation	Dr. Hoon-Ki Sung
January 25, 2024	Metabolic phenotyping and diet intervention of metabolic disease: Metabolic phenotyping and clinical translation. Therapeutic approaches for metabolic diseases and the impact of diet interventions.	Dr. Hoon-Ki Sung
February 1, 2024	Presentation and summary. Group presentation and summary.	Dr. Hoon-Ki Sung
	Lipids and dyslipidemia
February 8, 2024	Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia)	Dr. Jennifer Taher / Dr. Corey Scipione
February 15, 2024	Midterm exam covering material from Lectures 1 - 5
February 22, 2024	Reading Week (no class)
February 29, 2024	Disorders leading to dysglycemia	Dr. Jennifer Taher / Dr. Corey Scipione
March 7, 2024	Analytical principles of lipids, lipoproteins and glycemic control testing	Dr. Jennifer Taher / Dr. Corey Scipione
	Aminoacidopathies and lysosomal storage disorders
March 14, 2024	Inborn errors of metabolism (aminoacidopathies)	Dr. Libin Yuan
March 21, 2024	Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias)	Dr. Libin Yuan
March 28, 2024	Inborn errors of metabolism (lysosomal storage disorders 1)	Dr. Libin Yuan
April 4, 2024	Inborn errors of metabolism (lysosomal storage disorders 2)	Dr. Libin Yuan
TBC	Final exam covering lectures 6 - 11