LMP430H1 – Metabolic disorders
Course description
This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.
You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.
Course coordinators
Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710
hoon-ki.sung@sickkids.ca
Office address: Sinai Health Systems, 600 University Ave
jennifer.taher@sinaihealth.ca
Office address: SickKids, 555 University Ave, Roy C Hill Wing
libin.yuan@sickkids.ca
Teaching assistant
Danielle Alvares
danielle.alvares@mail.utoronto.ca
Term |
Winter 2023 |
Lecture location and time |
Thursday 1 - 3 pm PB 255, Leslie Dan Pharmacy Building |
Tutorial location and time |
Thursday 3 - 4 pm PB 255, Leslie Dan Pharmacy Building |
Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite: BCH210H1, PSL300H1
- Exclusions: None
- Recommended preparation: PSL425H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 30 students
Student evaluation
Group presentation (Lectures 1,2, and 3): 20% (February 2)
Midterm test (Lectures 1-5): 20% (February 16)
Participation: 10%
Final exam (Lectures 6-11): 50% (Timing TBD)
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
Date |
Topic |
Instructor |
---|---|---|
Metabolism |
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January 12, 2023 |
Energy Homeostasis and metabolic regulation:
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January 19, 2023 |
Metabolic function of major metabolic organs:
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January 26, 2023 |
Metabolic Analysis and Phenotyping 1 - In vivo metabolic analysis, phenotyping and clinical translation |
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February 2, 2023 |
Metabolic phenotyping and diet intervention of metabolic disease:
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Lipids and dyslipidemia |
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February 9, 2023 |
Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia) |
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February 16, 2023 |
Midterm exam covering material from Lectures 1 - 5 |
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February 23, 2023 |
Reading Week (no class) |
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March 2, 2023 |
Disorders leading to dysglycemia |
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March 9, 2023 |
Analytical principles of lipids, lipoproteins and glycemic control testing |
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Aminoacidopathies and lysosomal storage disorders |
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March 16, 2023 |
Inborn errors of metabolism (aminoacidopathies) |
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March 23, 2023 |
Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias) |
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March 30, 2023 |
Inborn errors of metabolism (lysosomal storage disorders 1) |
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April 6, 2023 |
Inborn errors of metabolism (lysosomal storage disorders 2) |
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TBC |
Final exam covering lectures 6 - 11 |
Recommended reading or text book
None.