LMP430H1 – Metabolic disorders

Course description

This is an advanced-level course that focuses on the pathobiology of metabolic disorders, whether inherited or acquired.

You will learn about enzymatic pathways and diseases associated with fat/energy metabolism, dyslipidemia, dysglycemia, aminoacidopathies and lysosomal storage disorders.

Course coordinators

Dr. Hoon-Ki Sung

Office address: SickKids, 686 Bay St, PGCRL, Rm 10.9710 
hoon-ki.sung@sickkids.ca

Dr. Jennifer Taher

Office address: Sinai Health Systems, 600 University Ave
jennifer.taher@sinaihealth.ca

Dr. Libin Yuan

Office address: SickKids, 555 University Ave, Roy C Hill Wing
libin.yuan@sickkids.ca

Teaching assistant

Danielle Alvares

danielle.alvares@mail.utoronto.ca 

Term

Winter 2023

Lecture location and time

Thursday 1 - 3 pm

PB 255, Leslie Dan Pharmacy Building

Tutorial location and time

Thursday 3 - 4 pm

PB 255, Leslie Dan Pharmacy Building

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite: BCH210H1, PSL300H1
  • Exclusions: None
  • Recommended preparation: PSL425H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation

Midterm test: 40%

Participation: 10%

Final exam: 50%

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date

Topic

Instructor

 

Metabolism

 

Lecture 1

Energy Homeostasis and Metabolic Regulation 1 - General overview and introduction of major metabolic organs

Dr. Hoon-Ki Sung

Lecture 2

Energy Homeostasis and Metabolic Regulation 2 - Pathobiology of metabolic regulation in the brain, muscle, adipose tissue, kidney and liver

Dr. Hoon-Ki Sung

Lecture 3

Metabolic Analysis and Phenotyping 1 - In vivo metabolic analysis, phenotyping and clinical translation

Dr. Hoon-Ki Sung

Lecture 4

Metabolic Analysis and Phenotyping 2 - Histopathology and biochemical analysis for phenotyping and diagnosis

Dr. Hoon-Ki Sung

 

Lipids and dyslipidemia

 

Lecture 5

Pathobiology of dyslipidemias (familial dyslipidemia, ectopic fat accumulation, hypertriglyceridemia)

Dr. Jennifer Taher

Lecture 6

Disorders leading to dysglycemia

Dr. Jennifer Taher

Lecture 7

Analytical principles of lipids, lipoproteins and glycemic control testing

Dr. Jennifer Taher

 

Aminoacidopathies and lysosomal storage disorders 

 

Lecture 8

Inborn errors of metabolism (aminoacidopathies) 

Dr. Libin Yuan

Lecture 9

Inborn errors of metabolism (fatty acid oxidation disorders and organic acidurias)

Dr. Libin Yuan

Lecture 10

Inborn errors of metabolism (lysosomal storage disorders 1)

Dr. Libin Yuan

Lecture 11

Inborn errors of metabolism (lysosomal storage disorders 2) 

Dr. Libin Yuan

Recommended reading or text book

None.