LMP301H1 - Introduction to the Biochemistry of Human Disease

Not intended for students in the Pathobiology Specialist program.

Course description

This course introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children, 555 University Ave., Room S102 Elm Wing

lianna.kyriakopoulou@sickkids.ca

Dr. Lusia Sepiashvili

Hospital for Sick Children, 555 University Ave., Rm 3606 Atrium

lusia.sepiashvili@sickkids.ca

Teaching assistant

Karen Fang

k.fang@mail.utoronto.ca

Term	Winter 2025
Class time	Tuesday and Thursday 12 - 1 pm
Class and office hours location	Please see ACORN for location.
Office hours	Thursdays 1 - 2 pm on January 30, March 13, and April 3

Course details

Hours: 24L
Prerequisite: BCH210H1/ BCH242Y1
Exclusions: LMP340H1 / LMP350H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

See information on Academic Integrity

Schedule

Date	Title	Instructor
January 7, 2025	Introduction to human disease	Dr. Lianna Kyriakopoulou
January 9, 2025	Laboratory tests and interpretation	Dr. Lianna Kyriakopoulou
January 14, 2025	Introduction to cases	Dr. Lianna Kyriakopoulou
January 16, 2025	Water and electrolytes	Dr. Rajeevan Selvaratnam
January 21, 2025	Acid-Base disorders	Dr. Rajeevan Selvaratnam
January 23, 2025	Renal disease	Dr. Rajeevan Selvaratnam
January 28, 2025	Lipids and cardiac disease	Dr. Rajeevan Selvaratnam
January 30, 2025	Liver Disease Office Hour	Dr. Lusia Sepiashvili
February 4, 2025	Viral hepatitis	Dr. Lusia Sepiashvili
February 6, 2025	First Mid-term Exam (Covers Lectures 1-7)
February 11, 2025	Introduction to endocrine diseases	Dr. Matthew Lafreniere
February 13, 2025	Thyroid disease	Dr. Matthew Lafreniere
February 17-21, 2025	Reading Week
February 25, 2025	Adrenal disease	Dr. Matthew Lafreniere
February 27, 2025	Calcium, Vitamin D and Parathyroid	Dr. Matthew Lafreniere
March 4, 2025	Infertility	Dr. Lianna Kyriakopoulou
March 6, 2025	Diabetes	Dr. Lianna Kyriakopoulou
March 11 2025	Iron and heme	Dr. Lianna Kyriakopoulou
March 13, 2025	Cancer markers Office hour	Dr. Lianna Kyriakopoulou
March 18, 2025	Second Mid-term Exam (covers lectures 8 - 15)
March 20, 2025	Newborn screening	Dr. Lianna Kyriakopoulou
March 25, 2025	Pregnancy	Dr. Lei Fu
March 27, 2025	Therapeutic drug monitoring & Personalized medicine	Dr. Benjamin Jung
April 1, 2025	Clinical Toxicology	Dr. Benjamin Jung
April 3, 2025	Molecular diagnostics Office Hour	Dr. Lei Fu
TBC	Final Exam (covers lectures 1-22)