LMP301H1 - Introduction to the Biochemistry of Human Disease

Course description

This course introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Not intended for students in the Pathobiology Specialist program.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children, 555 University Ave., Room S102 Elm Wing


Dr. Lusia Sepiashvili

Hospital for Sick Children, 555 University Ave., Room 3606 Atrium


Teaching assistant

Justin Meade



 Winter 2024

Class time

Tuesday 12 - 1 pm

Thursday 12 - 1 pm

Office hours

Thursday 1 - 2 pm

Course details

  • Hours: 24L
  • Prerequisite: BCH210H1/​ BCH242Y1
  • ExclusionsLMP310H1 and LMP320H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

See information on Academic Integrity





January 10, 2023

Introduction to human disease

Dr. Lianna Kyriakopoulou

January 12, 2023

Laboratory tests and interpretation

Dr. Lianna Kyriakopoulou

January 17, 2023

Introduction to cases

Dr. Lianna Kyriakopoulou

January 19, 2023

Water and electrolytes

Dr. Rajeevan Selvaratnam

January 24, 2023

Acid-Base disorders

Dr. Rajeevan Selvaratnam

January 26, 2023

Renal disease

Dr. Rajeevan Selvaratnam

January 31, 2023

Lipids and cardiac disease

Dr. Rajeevan Selvaratnam

February 2, 2023

Liver Disease and Office Hour

Dr. Lusia Sepiashvili

February 7, 2023

Viral hepatitis

Dr. Lusia Sepiashvili

February 9, 2023

First Mid-term Exam (Covers Lectures 1-7)


February 14 2023

Introduction to endocrine diseases

Dr. Benjamin Jung

February 16, 2023

Thyroid disease

Dr. Lusia Sepiashvili

February 20, 2023

Reading Week


February 28, 2023

Adrenal disease

Dr. Benjamin Jung

March 2, 2023

Calcium, Vitamin D and Parathyroid  

Dr. Benjamin Jung

March 7, 2023


Dr. Lianna Kyriakopoulou

March 9, 2023

Diabetes and Office Hour

Dr. Lianna Kyriakopoulou

March 14, 2023

Iron and heme

Dr. Lianna Kyriakopoulou

March 16, 2023

Cancer markers

Dr. Lianna Kyriakopoulou

March 21, 2023

Second Mid-term Exam (covers lectures 8 - 15)


March 23, 2023

Newborn screening

Dr. Lianna Kyriakopoulou

March 28, 2023


Dr. Lei Fu

March 28, 2023

Supplemental Exam


March 30, 2023

Clinical toxicology

Dr. Lei Fu

April 4, 2023

Therapeutic drug monitoring & Personalized medicine

Dr. Lei Fu

April 6, 2023

Molecular diagnostics and Office Hour

Dr. Lei Fu


Final Exam (covers lectures 1-22)


Recommended readings or text book

“Clinical Biochemistry 5th edition” by A. Gaw, M.J. Murphy, R. Srivastava, R.A. Cowan, and D.St.J. O’Reilly, published by Churchill Livingston, 2013.