LMP301H1 - Introduction to the Biochemistry of Human Disease

Not intended for students in the Pathobiology Specialist program.

Course description

This course introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children, 555 University Ave., Room S102 Elm Wing

lianna.kyriakopoulou@sickkids.ca

Dr. Lusia Sepiashvili

Hospital for Sick Children, 555 University Ave., Rm 3606 Atrium

lusia.sepiashvili@sickkids.ca

Teaching assistant

Karen Fang

k.fang@mail.utoronto.ca

Term	Winter 2026
Class time	Tuesday and Thursday 12 - 1 pm
Class and office hours location	Please see ACORN for location.
Office hours	Thursdays 1 - 2 pm from January 6 - April 2, 2026

Course details

Hours: 24L
Prerequisite: BCH210H1/ BCH242Y1
Exclusions: LMP340H1 / LMP350H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

See information on Academic Integrity

Schedule

Date	Title	Instructor
January 6, 2026	Introduction to human disease	Dr. Lianna Kyriakopoulou
January 8, 2026	Laboratory tests and interpretation	Dr. Lianna Kyriakopoulou
January 13, 2026	Introduction to cases	Dr. Lianna Kyriakopoulou
January 15, 2026	Water and electrolytes	Dr. Rajeevan Selvaratnam
January 20, 2026	Acid-Base disorders	Dr. Rajeevan Selvaratnam
January 22, 2026	Liver disease	Dr. Lusia Sepiashvili
January 27, 2026	Renal disease	Dr. Rajeevan Selvaratnam
January 29, 2026	Lipids and cardiac disease Office Hour	Dr. Rajeevan Selvaratnam
February 3, 2026	Viral hepatitis	Dr. Lusia Sepiashvili
February 5, 2026	First Mid-term Exam (Covers Lectures 1-7)
February 10, 2026	Introduction to endocrine diseases	Dr. Matthew Lafreniere
February 12, 2026	Thyroid disease	Dr. Matthew Lafreniere
February 16-20, 2026	Reading Week
February 24, 2026	Adrenal disease	Dr. Matthew Lafreniere
February 26, 2026	Calcium, Vitamin D and Parathyroid	Dr. Matthew Lafreniere
March 3, 2026	Infertility	Dr. Lianna Kyriakopoulou
March 5, 2026	Diabetes	Dr. Lianna Kyriakopoulou
March 10, 2026	Iron and heme	Dr. Lianna Kyriakopoulou
March 12, 2026	Cancer markers Office hour	Dr. Lianna Kyriakopoulou
March 17, 2026	Second Mid-term Exam (covers lectures 8 - 15)
March 19, 2026	Newborn screening	Dr. Lianna Kyriakopoulou
March 24, 2026	Pregnancy	Dr. Lei Fu
March 26, 2026	Therapeutic drug monitoring	Dr. Benjamin Jung
March 31, 2026	Clinical Toxicology	Dr. Benjamin Jung
April 2, 2026	Molecular diagnostics Office Hour	Dr. Lei Fu
TBC	Final Exam (covers lectures 1-22)