LMP301H1 - Introduction to the Biochemistry of Human Disease

Course description

Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Not intended for students in the Pathobiology Specialist program.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children
555 University Ave.
Room S102 Elm Wing


Dr. Lusia Sepiashvili

Hospital for Sick Children
555 University Ave.
Room 3606 Atrium


Teaching assistant

Chanele Polenz



 Winter 2022

Class location and time

Tuesday and Thursday 12 -1 pm

Online Synchronous until further notice.

Once in-person teaching resumes, classes will be held at:

MP 203 McLennan Physical Laboratories 

255 Huron Street TORONTO, M5S 1A7 

Office hours

Thursday 1 - 2 pm

Contact instructors or teaching assistant

Course details

  • Hours: 24L
  • Prerequisite: BCH210H1/​ BCH242Y1
  • Exclusions: LMP340H1/LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

Until further notice, the midterms are planned to be in-person. However, the situation is rapidly changing, and they may have to be moved to a virtual format (Quercus). The instructors will notify students immediately of any changes as they receive instructions from the University.

Missed assessments

If you miss the first or second midterm, the weight of the missed midterm will carry over to the completed midterm. 

If you miss the final exam, the midterms will be used for the final grade. 

See information on Academic Integrity





January 11, 2022

Introduction to human disease

Dr. Lianna Kyriakopoulou

January 13, 2022

Laboratory tests and interpretation

Dr. Lianna Kyriakopoulou

January 18, 2022

Introduction to cases

Dr. Lianna Kyriakopoulou

January 20, 2022

Water and electrolytes

Dr. Rajeevan Selvaratnam

January 25, 2022

Acid-Base disorders

Dr. Rajeevan Selvaratnam

January 27, 2022

Renal disease

Dr. Rajeevan Selvaratnam

February 1, 2022

Lipids and cardiac disease

Dr. Rajeevan Selvaratnam

February 3, 2022

Liver Disease

Dr. Lusia Sepiashvili

February 8, 2022

Viral hepatitis

Dr. Lusia Sepiashvili

February 10, 2022

First Mid Term Exam (Covers Lectures 1-7)


February 15 2022

Introduction to endocrine diseases

Dr. Benjamin Jung

February 17, 2022

Thyroid disease

Dr. Lusia Sepiashvili

February 21, 2022

Reading Week


February 23, 2021

First Mid Term Exam


March 1, 2022

Adrenal disease

Dr. Benjamin Jung

March 3, 2022

Calcium, Vitamin D and Parathyroid  

Dr. Benjamin Jung

March 8, 2022


Dr. Lianna Kyriakopoulou

March 10, 2022


Dr. Lusia Sepiashvili

March 15, 2022

Iron and heme

Dr. Lianna Kyriakopoulou

March 17, 2022

Cancer markers

Dr. Lusia Sepiashvili

March 22, 2022

Second mid-term exam


March 24, 2022

Newborn screening

Dr. Lianna Kyriakopoulou

March 29, 2022


Dr. Lei Fu

March 31, 2022

Clinical toxicology

Dr. Lei Fu

April 5, 2022

Therapeutic drug monitoring & Personalized medicine

Dr. Lei Fu

April 7, 2022

Molecular diagnostics

Dr. Lei Fu


Final Exam (Covers lectures 1-22)


Recommended readings or text book

“Clinical Biochemistry 5th edition” by A. Gaw, M.J. Murphy, R. Srivastava, R.A. Cowan, and D.St.J. O’Reilly, published by Churchill Livingston, 2013.