LMP301H1 - Introduction to the Biochemistry of Human Disease

Not intended for students in the Pathobiology Specialist program.

Course description

This course introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children, 555 University Ave., Room S102 Elm Wing


Dr. Lei Fu

Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, 2075 Bayview Avenue


Teaching assistant

Justin Meade



 Winter 2024

Class time

Tuesday and Thursday 12 - 1 pm

Class and office hours location

Please see ACORN for location.

Office hours

Thursday February 1, Thursday March 7, and Thursday April 4 - 1 - 2 pm

Course details

  • Hours: 24L
  • Prerequisite: BCH210H1/​ BCH242Y1
  • Exclusions: LMP340H1 / LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

See information on Academic Integrity





January 9, 2024

Introduction to human disease

Dr. Lianna Kyriakopoulou

January 11, 2024

Laboratory tests and interpretation

Dr. Lianna Kyriakopoulou

January 16, 2024

Introduction to cases

Dr. Lianna Kyriakopoulou

January 18, 2024

Water and electrolytes

Dr. Rajeevan Selvaratnam

January 23, 2024

Acid-Base disorders

Dr. Rajeevan Selvaratnam

January 25, 2024

Renal disease

Dr. Rajeevan Selvaratnam

January 30, 2024

Lipids and cardiac disease

Dr. Rajeevan Selvaratnam

February 1, 2024

Liver Disease

Office Hour

Dr. Lianna Kyriakopoulou

February 6, 2024

Viral hepatitis

Dr. Lianna Kyriakopoulou

February 8, 2024

First Mid-term Exam (Covers Lectures 1-7)


February 13, 2024

Introduction to endocrine diseases

Dr. Benjamin Jung

February 15, 2024

Thyroid disease

Supplemental Exam

Dr. Lianna Kyriakopoulou

February 19, 2024

Reading Week


February 27, 2024

Adrenal disease

Dr. Benjamin Jung

February 29, 2024

Calcium, Vitamin D and Parathyroid  

Dr. Benjamin Jung

March 5, 2024


Dr. Lianna Kyriakopoulou

March 7, 2024


Office Hour

Dr. Lianna Kyriakopoulou

March 12, 2024

Iron and heme

Dr. Lianna Kyriakopoulou

March 14, 2024

Cancer markers

Dr. Lianna Kyriakopoulou

March 19, 2024

Second Mid-term Exam (covers lectures 8 - 15)


March 21, 2024

Newborn screening

Dr. Lianna Kyriakopoulou

March 26, 2024


Dr. Lei Fu

March 28, 2024

Clinical toxicology

Supplemental Exam

Dr. Lei Fu

April 2, 2024

Therapeutic drug monitoring & Personalized medicine

Dr. Lei Fu

April 4, 2024

Molecular diagnostics

Office Hour

Dr. Lei Fu


Final Exam (covers lectures 1-22)


Recommended readings or text book

“Clinical Biochemistry 5th edition” by A. Gaw, M.J. Murphy, R. Srivastava, R.A. Cowan, and D.St.J. O’Reilly, published by Churchill Livingston, 2013.