LMP301H1 - Introduction to the Biochemistry of Human Disease

Course description

Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Not intended for students in the Pathobiology Specialist program.                                                                         

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children
555 University Ave.
Room S102 Elm Wing


Dr. Lusia Sepiashvili

Hospital for Sick Children
555 University Ave.
Room 3606 Atrium


Teaching assistant

Chanele Polenz



 Winter 2021

Class location and time

Tuesday and Thursday 12:00 -1:00 pm

Online Synchronous

Office hours

Thursday 1:00-2:00 pm

Contact instructors or teaching assistant

Course details

  • Hours: 24L
  • Prerequisite: BCH210H1/​ BCH242Y1
  • Exclusions: LMP340H1/LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

Schedule - Winter 2021

See information on Academic Integrity





January 12, 2021

Introduction to human disease

Lianna Kyriakopoulou

January 14, 2021

Laboratory tests and interpretation & introduction to cases

Lianna Kyriakopoulou

January 19, 2021

Water and electrolytes

Rajeevan Selvaratnam

January 21, 2021

Acid-Base disorders

Rajeevan Selvaratnam

January 26, 2021

Renal disease

Rajeevan Selvaratnam

January 28, 2021

Lipids and cardiac disease

Rajeevan Selvaratnam

February 2, 2021

Liver Disease

Lusia Sepiashvili

February 4, 2021

Viral hepatitis

Lusia Sepiashvili

February 9, 2021

Introduction to endocrine diseases

Benjamin Jung

February 11, 2021

Thyroid disease

Lusia Sepiashvili

February 15 to 19

Reading Week


February 23, 2021

First Mid Term Exam


February 25, 2021

Adrenal disease

Benjamin Jung

March 2, 2021


Lianna Kyriakopoulou

March 4, 2021

Calcium, Vitamin D and Parathyroid 

Benjamin Jung

March 9, 2021


Lusia Sepiashvili

March 11, 2021

Iron and heme

Lianna Kyriakopoulou

March 16, 2021

Cancer markers

Lusia Sepiashvili

March 18, 2021

Newborn screening

Lianna Kyriakopoulou

March 23, 2021

Second mid-term exam


March 25, 2021


Lei Fu

March 30, 2021

Clinical toxicology

Lei Fu

April 1, 2021

Therapeutic drug monitoring & Personalized medicine

Lei Fu

April 6, 2021

Molecular diagnostics

Lei Fu

Recommended readings or text book

“Clinical Biochemistry 5th edition” by A. Gaw, M.J. Murphy, R. Srivastava, R.A. Cowan, and D.St.J. O’Reilly, published by Churchill Livingston, 2013.