LMP301H1 - Introduction to the Biochemistry of Human Disease

Course description

Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Not intended for students in the Pathobiology Specialist program.                                                                         

Course coordinator

Dr Lianna Kyriakopoulou

Hospital for Sick Children
555 University Ave.
Room S102 Elm Wing



Dr Lusia Sepiashvili

Hospital for Sick Children
555 University Ave.
Room 3606 Atrium


Teaching assistant

Chanele Polenz


Term  Winter 2021
Class location and time

Tuesday and Thursday 12:00 -1:00 pm

Online Synchronous

Office hours

Thursday 1:00-2:00 pm

Contact instructors or teaching assistant

Course details

  • Hours: 24L
  • Prerequisite: BCH210H1/​ BCH242Y1
  • Exclusions: LMP340H1/LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

Schedule - Winter 2021

See information on Academic Integrity


Date Title Instructor
January 12, 2021 Introduction to human disease Lianna Kyriakopoulou
January 14, 2021 Laboratory tests and interpretation & introduction to cases Lianna Kyriakopoulou
January 19, 2021 Water and electrolytes Rajeevan Selvaratnam
January 21, 2021 Acid-Base disorders Rajeevan Selvaratnam
January 26, 2021 Renal disease Rajeevan Selvaratnam
January 28, 2021 Lipids and cardiac disease Rajeevan Selvaratnam
February 2, 2021 Liver Disease Lusia Sepiashvili
February 4, 2021 Viral hepatitis Lusia Sepiashvili
February 9, 2021 Introduction to endocrine diseases Benjamin Jung
February 11, 2021 Thyroid disease Lusia Sepiashvili
February 15 to 19 Reading Week  
February 23, 2021 First Mid Term Exam  
February 25, 2021 Adrenal disease Benjamin Jung
March 2, 2021 Infertility Lianna Kyriakopoulou
March 4, 2021 Calcium, Vitamin D and Parathyroid  Benjamin Jung
March 9, 2021 Diabetes Lusia Sepiashvili
March 11, 2021 Iron and heme Lianna Kyriakopoulou
March 16, 2021 Cancer markers Lusia Sepiashvili
March 18, 2021 Newborn screening Lianna Kyriakopoulou
March 23, 2021 Second mid-term exam  
March 25, 2021 Pregnancy Lei Fu
March 30, 2021 Clinical toxicology Lei Fu
April 1, 2021 Therapeutic drug monitoring & Personalized medicine Lei Fu
April 6, 2021 Molecular diagnostics Lei Fu

Recommended readings or text book

“Clinical Biochemistry 5th edition” by A. Gaw, M.J. Murphy, R. Srivastava, R.A. Cowan, and D.St.J. O’Reilly, published by Churchill Livingston, 2013.