LMP330H1 – Genetic and Computational Modeling in Human Development and Disease

Course description

Enrolment is limited to students in the Pathobiology specialist program.

This course introduces the use and impact of genetic model systems and organisms in exploring aspects of human reproduction, development, aging and disease.

We will highlight ethical issues in animal research, genetic manipulation, and disease modeling.

This course also introduces the bioinformatics concepts and methods used in biological data analysis.

Course coordinators

Dr. David Irwin

Office address: 1 King’s College Circle, MSB Room 6211

Dr. Karim Mekhail

Office address: 661 University Ave, MaRS Centre West Tower Room 1513 

Dr. Bo Wang

Office address: UHN, 190 Elizabeth St, 3rd floor 

Teaching assistant



Fall 2022

Class location and time


Tutorial location and time


Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program
  • Prerequisite: LMP200H1, BIO260H1/HMB265H1
  • Exclusions: LMP408H1
  • Recommended preparation: None
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)          
  • Enrolment limits: 35 students

Student evaluation


See information on Academic Integrity


Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus




Lecture 1

Introduction to genetic and computational modeling in disease


Lecture 2

Model species used in biology


Lecture 3

Mouse modeling of human diseases


Lecture 4

Flies in neurodegeneration 


Lecture 5

Zebrafish in vascular development 


Lecture 6

Stem cell/iPS models for human development and disease


Lecture 7

Scientific debate of genetic model papers


Lecture 8

Biomedical databases


Lecture 9

Bioinformatic analysis of data from model species I


Lecture 10

Bioinformatic analysis of data from model species II 


Lecture 11

Student presentations


Recommended reading or text book