LMP330H1 – Genetic and Computational Modeling in Human Development and Disease
Course description
Enrolment is limited to students in the Pathobiology specialist program.
This course introduces the use and impact of genetic model systems and organisms in exploring aspects of human reproduction, development, aging and disease.
We will highlight ethical issues in animal research, genetic manipulation, and disease modeling.
This course also introduces the bioinformatics concepts and methods used in biological data analysis.
Course coordinators
Office address: 1 King’s College Circle, MSB Room 6211
david.irwin@utoronto.ca
Office address: 661 University Ave, MaRS Centre West Tower Room 1513
karim.mekhail@utoronto.ca
Office address: UHN, 190 Elizabeth St, 3rd floor
bowang.wang@utoronto.ca
Teaching assistant
Negin Khosraviani
negin.khosraviani@mail.utoronto.ca
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Term |
Fall 2022 |
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Class location and time |
Tuesday 9 - 11 am MSB 4171, Medical Sciences Building |
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Tutorial location and time |
Tuesday 11 am - 12 pm MSB 4171, Medical Sciences Building |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program
- Prerequisite: LMP200H1, BIO260H1/HMB265H1
- Exclusions: LMP408H1
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
The grade for this course (LMP330) will be divided among assignment, participation/group activities, and a final assessment. There will be three assignments (see Quercus for more details), participation will be assessed for the Phenotate and debate classes, and the final assessment will cover material from all lectures in the course.
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Date Issued |
Due Date |
Title |
Coordinator |
Percentage |
|---|---|---|---|---|
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September 27 |
September 29 October 14 November 14 December 5 |
Phenotate Assignment 1 Assignment 2 Assignment 3 |
5% 10% 15% 15% |
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December 6 |
December 6 |
Debate |
All |
15% |
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TBA |
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Final Assessment |
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40% |
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Coordinator |
Lecturer |
|---|---|---|---|
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September 13 |
Introduction to model species |
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September 20 |
Human genomics and biomedical genetics |
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September 27 |
Phenotate |
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October 4 |
Caenorhabditis elegans models |
P. Roy |
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October 11 |
Yeast models and human disease |
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October 18 |
Mouse modeling of human diseases |
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October 25 |
Zebrafish in vascular development |
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November 1 |
Stem cell/iPS models for human development and disease |
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November 7-11 |
Reading Week |
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November 15 |
Biomedical databases |
G. Bader |
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November 22 |
Bioinformatic and multi-omnics |
B. Haibe-Kains |
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November 29 |
Introduction to machine learning |
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December 6 |
Scientific debate of genetic model papers |
All |
All |
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TBA |
Final Assessment |
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Recommended reading or text book
Links to recommended/required readings (journal articles) will be posted on Quercus.