LMP330H1 – Genetic and Computational Modeling in Human Development and Disease
Course description
Enrolment is limited to students in the Pathobiology specialist program.
This course introduces the use and impact of genetic model systems and organisms in exploring aspects of human reproduction, development, aging and disease.
We will highlight ethical issues in animal research, genetic manipulation, and disease modeling.
This course also introduces the bioinformatics concepts and methods used in biological data analysis.
Course coordinators
Office address: 1 King’s College Circle, MSB Room 6211
david.irwin@utoronto.ca
Office address: 661 University Ave, MaRS Centre West Tower Room 1513
karim.mekhail@utoronto.ca
Office address: UHN, 190 Elizabeth St, 3rd floor
bowang.wang@utoronto.ca
Teaching assistant
TBC
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Term |
Fall 2022 |
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Class location and time |
TBC |
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Tutorial location and time |
TBC |
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Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology specialist program
- Prerequisite: LMP200H1, BIO260H1/HMB265H1
- Exclusions: LMP408H1
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
TBC
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
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Lecture 1 |
Introduction to genetic and computational modeling in disease |
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Lecture 2 |
Model species used in biology |
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Lecture 3 |
Mouse modeling of human diseases |
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Lecture 4 |
Flies in neurodegeneration |
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Lecture 5 |
Zebrafish in vascular development |
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Lecture 6 |
Stem cell/iPS models for human development and disease |
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Lecture 7 |
Scientific debate of genetic model papers |
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Lecture 8 |
Biomedical databases |
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Lecture 9 |
Bioinformatic analysis of data from model species I |
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Lecture 10 |
Bioinformatic analysis of data from model species II |
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Lecture 11 |
Student presentations |
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Recommended reading or text book
None.