LMP200H1 – Pathobiology of the Cell

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.                                                                   

Course coordinator

Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275

doug.templeton@utoronto.ca

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314

jeff.lee@utoronto.ca

Teaching assistant

Karen Fang

k.fang@mail.utoronto.ca

Term

 Winter 2022

Class location and time

Friday 3:00 - 5:00 pm

MSB 3278 

Online via Zoom for lectures 1 - 3 (Jan 14- Jan 28).

Format of classes in February will be announced by UofT/A&S in January.

Tutorial location and time: 

Tuesday 2:00 - 3:00pm

MSB 3278

Online via Zoom for tutorials 1 - 3 (Jan 11- Jan 25).

Format of classes in February will be announced by UofT/A&S in January.

Office hours

Contact instructors or teaching assistant

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
  • PrerequisiteBIO230H1, PSL300H1
  • ExclusionsLMP340H1
  • Recommended preparation: BCH210H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 35 students

Student evaluation

Midterm exam: 35%

Assignment (due April 8): 30%

Final exam: 35%

See information on Academic Integrity

Schedule

Date

Title

Instructor

January 14, 2022

Mechanisms of cell injury 

Dr. Doug Templeton

January 21, 2022

Cell adaptation and cell death

Dr. Doug Templeton

January 28, 2022

Oxidative stress, ER stress and defenses

Dr. Doug Templeton

February 4, 2022

Calcium homeostasis/signaling/metabolism 

Dr. Doug Templeton

February 11, 2022

Ion channels/pumps

Dr. Doug Templeton

February 18, 2022

Iron homeostasis/metabolism and associated 
diseases

Dr. Doug Templeton

February 25, 2022

Reading Week - no class

 

March 4, 2022

Midterm (2 hours)

 

March 11, 2022

Transport through the membrane and 
exploitation by pathogens

Dr. Jeff Lee

March 18, 2022

Protein misfolding, trafficking and 
proteinopathies

Dr. Jeff Lee

March 25, 2022

Protein degradation and associated diseases

Dr. Jeff Lee

April 1, 2022

Cell signaling and cancer 

Dr. Jeff Lee

April 8, 2022

Cytoskeleton and related diseases

Final exam

Dr. Jeff Lee

Tutorials

Date

Topic

Instructor

January 11, 2022

Pathobiology- What and How?  

Dr. Doug Templeton

January 18, 2022

Histology in a nutshell

Dr. Doug Templeton

January 25, 2022

Assignment discussion

Dr. Doug Templeton

Dr. Jeff Lee

February 1, 2022

Lecture material review and Q&A session

Karen Fang

February 8, 2022

Structure-function of ion channel and pumps

Dr. Jeff Lee

February 15, 2022

Stem cells and developmental biology

Karen Fang

February 22, 2022

Reading break - no tutorial

 

March 1, 2022

Midterm exam material review and Q&A session 

Karen Fang

March 8, 2022

Critiquing research papers 

Dr. Doug Templeton

Dr. Jeff Lee

March 15, 2022

Paper discussion- SARS-CoV-2 

Dr. Jeff Lee

March 22, 2022

Lecture material review and Q&A session 

Karen Fang

March 29, 2022

Paper discussion - ubiquitin 

Dr. Jeff Lee

April 5, 2022

Final exam material review and Q&A session 

Karen Fang

Recommended readings or text book

Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.