LMP200H1 – Pathobiology of the Cell
Enrolment is limited to students in the Pathobiology Specialist program.
Course description
This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.
We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.
By the end of the course, you should have a strong foundation in concepts in cellular pathobiology. You will be well prepared for 300-level LMP courses.
Course coordinator
Office address: 1 King’s College Circle, MSB 6314
Office address: 1 King’s College Circle, MSB 6275
Teaching Assistant
Amanda Mao
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Term |
Winter 2024 |
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Lecture time |
Friday 3 - 5 pm |
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Tutorial time |
Tuesday 2 - 3 pm |
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Office hours |
By appointment |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
- Prerequisite: BIO230H1, PSL300H1
- Exclusions: LMP340H1, LMP363H1
- Recommended preparation: BCH210H1
- Credit value: 0.5
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Midterm exam (due 1 March, 2024: 35%
Assignment (due 5 April, 2024): 30%
Final exam: 35%
Late submissions will incur a 5% penalty per day late.
See information on Academic Integrity
Schedule
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Date |
Title |
Instructor |
|---|---|---|
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January 12, 2024 |
Mechanisms of cell injury |
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January 19, 2024 |
Cell adaptation and cell death |
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January 26, 2024 |
Oxidative stress, ER stress and defenses |
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February 2, 2024 |
Calcium homeostasis/ signaling/ metabolism |
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February 9, 2024 |
Ion channels/pumps |
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February 16, 2024 |
Iron homeostasis/ metabolism and associated diseases |
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February 23, 2024 |
Reading Week - no class |
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March 1, 2024 |
Midterm (2 hours) |
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March 8, 2024 |
Transport through the membrane and exploitation by pathogens |
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March 15, 2024 |
Cytoskeleton and its role in the lifecycle of pathogens and neurodegenerative diseases |
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March 22, 2024 |
Protein misfolding, trafficking and proteinopathies |
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March 29, 2024 |
Good Friday - no class |
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April 5, 2024 |
Protein degradation and associated diseases |
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April 9, 2024 |
Cell signaling and cancer - make-up class for Mar 29 due to Good Friday (location and time tbd) |
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April 10 - 30, 2024 |
Final exam period |
Tutorials
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Date |
Topic |
Instructor |
|---|---|---|
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January 9, 2024 |
Pathobiology. What and How? |
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January 16, 2024 |
Histology in a nutshell |
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January 23, 2024 |
Assignment discussion |
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January 30, 2024 |
Lecture material review and Q&A session |
Amanda Mao |
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February 6, 2024 |
Structure-function of ion channel and pumps |
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February 13, 2024 |
Cellular and molecular mechanisms involved in atherosclerotic calcification |
Amanda Mao |
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February 20, 2024 |
Reading break - no tutorial |
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February 27, 2024 |
Midterm exam material review and Q&A session |
Amanda Mao |
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March 5, 2024 |
Critiquing research papers |
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March 12, 2024 |
Paper discussion: viral entry |
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March 19, 2024 |
Lecture material review and Q&A session |
Amanda Mao |
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March 26, 2024 |
Paper discussion: ubiquitin |
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April 2, 2024 |
Final exam material review and Q&A session |
Amanda Mao |
Recommended readings or text book
Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.