LMP200H1 – Pathobiology of the Cell

Enrolment is limited to students in the Pathobiology Specialist program.  

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease. 

By the end of the course, you should have a strong foundation in concepts in cellular pathobiology. You will be well prepared for 300-level LMP courses.             

Course coordinator

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314


Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275


Teaching Assistant

Amanda Mao



 Winter 2024

Lecture time

Friday 3 - 5 pm

Tutorial time

Tuesday 2 - 3 pm

Office hours

By appointment

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
  • PrerequisiteBIO230H1, PSL300H1
  • ExclusionsLMP340H1LMP363H1, LMP340H1 
  • Recommended preparation: BCH210H1
  • Credit value: 0.5
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 35 students

Student evaluation

Midterm exam (due 1 March, 2024: 35%

Assignment (due 5 April, 2024): 30%

Final exam: 35%

Late submissions will incur a 5% penalty per day late. 

See information on Academic Integrity





January 12, 2024

Mechanisms of cell injury 

Dr. Doug Templeton

January 19, 2024

Cell adaptation and cell death

Dr. Doug Templeton

January 26, 2024

Oxidative stress, ER stress and defenses

Dr. Doug Templeton

February 2, 2024

Calcium homeostasis/ signaling/ metabolism 

Dr. Doug Templeton

February 9, 2024

Ion channels/pumps

Dr. Doug Templeton

February 16, 2024

Iron homeostasis/ metabolism and associated diseases

Dr. Doug Templeton

February 23, 2024

Reading Week - no class


March 1, 2024

Midterm (2 hours)


March 8, 2024

Transport through the membrane and exploitation by pathogens

Dr. Jeff Lee

March 15, 2024

Cytoskeleton and its role in the lifecycle of pathogens and neurodegenerative diseases

Dr. Jeff Lee

March 22, 2024

Protein misfolding, trafficking and proteinopathies

Dr. Jeff Lee

March 29, 2024

Good Friday - no class

Dr. Jeff Lee

April 5, 2024

Protein degradation and associated diseases

Dr. Jeff Lee

April 9, 2024

Cell signaling and cancer - make-up class for Mar 29 due to Good Friday (location and time tbd)

Dr. Jeff Lee

April 10 - 30, 2024

Final exam period






January 9, 2024

Pathobiology. What and How?  

Dr. Doug Templeton

January 16, 2024

Histology in a nutshell

Dr. Doug Templeton

January 23, 2024

Assignment discussion

Dr. Doug Templeton

Dr. Jeff Lee

January 30, 2024

Lecture material review and Q&A session

Amanda Mao

February 6, 2024

Structure-function of ion channel and pumps

Dr. Jeff Lee

February 13, 2024

Cellular and molecular mechanisms involved in atherosclerotic calcification

Amanda Mao

February 20, 2024

Reading break - no tutorial


February 27, 2024

Midterm exam material review and Q&A session 

Amanda Mao

March 5, 2024

Critiquing research papers 

Dr. Doug Templeton

Dr. Jeff Lee

March 12, 2024

Paper discussion: viral entry

Dr. Jeff Lee

March 19, 2024

Lecture material review and Q&A session 

Amanda Mao

March 26, 2024

Paper discussion: ubiquitin 

Dr. Jeff Lee

April 2, 2024

Final exam material review and Q&A session 

Amanda Mao

Recommended readings or text book

Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.