LMP200H1 – Pathobiology of the Cell

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.

Course coordinator

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314

jeff.lee@utoronto.ca

Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275

doug.templeton@utoronto.ca

Teaching assistant

Danielle Karakas

danielle.karakas@mail.utoronto.ca

Term	Winter 2023
Lecture location and time	Friday 3 - 5 pm MSB 3278, Medical Sciences Building
Tutorial location and time:	Tuesday 2 - 3 pm BA 2155, Bahen Centre Information Tech, 40 St. George Street
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
Prerequisite: BIO230H1, PSL300H1
Exclusions: LMP340H1, LMP363H1, LMP340H1
Recommended preparation: BCH210H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 35 students

Student evaluation

Midterm exam: 35%

Assignment (due April 8): 30%

Final exam: 35%

See information on Academic Integrity

Schedule

Date	Title	Instructor
January 13, 2023	Mechanisms of cell injury	Dr. Doug Templeton
January 20, 2023	Cell adaptation and cell death	Dr. Doug Templeton
January 27, 2023	Oxidative stress, ER stress and defenses	Dr. Doug Templeton
February 3, 2023	Calcium homeostasis/ signaling/ metabolism	Dr. Doug Templeton
February 10, 2023	Ion channels/pumps	Dr. Doug Templeton
February 17, 2023	Iron homeostasis/ metabolism and associated diseases	Dr. Doug Templeton
February 24, 2023	Reading Week - no class
March 3, 2023	Midterm (2 hours)
March 10, 2023	Transport through the membrane and exploitation by pathogens	Dr. Jeff Lee
March 17, 2023	Protein misfolding, trafficking and proteinopathies	Dr. Jeff Lee
March 25, 2023	Protein degradation and associated diseases	Dr. Jeff Lee
March 31, 2023	Cell signaling and cancer	Dr. Jeff Lee
April 7, 2023	Cytoskeleton and related diseases Final exam	Dr. Jeff Lee

Tutorials

Date	Topic	Instructor
January 10, 2023	Pathobiology- What and How?	Dr. Doug Templeton
January 17, 2023	Histology in a nutshell	Dr. Doug Templeton
January 24, 2023	Assignment discussion	Dr. Doug Templeton Dr. Jeff Lee
January 31, 2023	Lecture material review and Q&A session	Danielle Karakas
February 7, 2023	Structure-function of ion channel and pumps	Dr. Jeff Lee
February 14, 2023	Stem cells and developmental biology	Danielle Karakas
February 21, 2023	Reading break - no tutorial
February 28, 2023	Midterm exam material review and Q&A session	Danielle Karakas
March 7, 2023	Critiquing research papers	Dr. Doug Templeton Dr. Jeff Lee
March 14, 2023	Paper discussion: SARS-CoV-2	Dr. Jeff Lee
March 21, 2023	Lecture material review and Q&A session	Danielle Karakas
March 28, 2023	Paper discussion: ubiquitin	Dr. Jeff Lee
April 4, 2023	Final exam material review and Q&A session	Danielle Karakas