LMP200H1 – Pathobiology of the Cell

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.                                                        

Course coordinator

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314

jeff.lee@utoronto.ca

Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275

doug.templeton@utoronto.ca

Teaching assistant

Danielle Karakas

danielle.karakas@mail.utoronto.ca

Term

 Winter 2023

Lecture location and time

Friday 3 - 5 pm

MSB 3278, Medical Sciences Building

Tutorial location and time: 

Tuesday 2 - 3 pm

BA 2155, Bahen Centre Information Tech, 40 St. George Street

Office hours

Contact TA or Course Coordinators

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
  • PrerequisiteBIO230H1, PSL300H1
  • ExclusionsLMP340H1
  • Recommended preparation: BCH210H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 35 students

Student evaluation

Midterm exam: 35%

Assignment (due April 8): 30%

Final exam: 35%

See information on Academic Integrity

Schedule

Date

Title

Instructor

January 13, 2023

Mechanisms of cell injury 

Dr. Doug Templeton

January 20, 2023

Cell adaptation and cell death

Dr. Doug Templeton

January 27, 2023

Oxidative stress, ER stress and defenses

Dr. Doug Templeton

February 3, 2023

Calcium homeostasis/ signaling/ metabolism 

Dr. Doug Templeton

February 10, 2023

Ion channels/pumps

Dr. Doug Templeton

February 17, 2023

Iron homeostasis/ metabolism and associated diseases

Dr. Doug Templeton

February 24, 2023

Reading Week - no class

 

March 3, 2023

Midterm (2 hours)

 

March 10, 2023

Transport through the membrane and 
exploitation by pathogens

Dr. Jeff Lee

March 17, 2023

Protein misfolding, trafficking and 
proteinopathies

Dr. Jeff Lee

March 25, 2023

Protein degradation and associated diseases

Dr. Jeff Lee

March 31, 2023

Cell signaling and cancer 

Dr. Jeff Lee

April 7, 2023

Cytoskeleton and related diseases

Final exam

Dr. Jeff Lee

Tutorials

Date

Topic

Instructor

January 10, 2023

Pathobiology- What and How?  

Dr. Doug Templeton

January 17, 2023

Histology in a nutshell

Dr. Doug Templeton

January 24, 2023

Assignment discussion

Dr. Doug Templeton

Dr. Jeff Lee

January 31, 2023

Lecture material review and Q&A session

Danielle Karakas

February 7, 2023

Structure-function of ion channel and pumps

Dr. Jeff Lee

February 14, 2023

Stem cells and developmental biology

Danielle Karakas

February 21, 2023

Reading break - no tutorial

 

February 28,  2023

Midterm exam material review and Q&A session 

Danielle Karakas

March 7, 2023

Critiquing research papers 

Dr. Doug Templeton

Dr. Jeff Lee

March 14, 2023

Paper discussion: SARS-CoV-2 

Dr. Jeff Lee

March 21, 2023

Lecture material review and Q&A session 

Danielle Karakas

March 28, 2023

Paper discussion: ubiquitin 

Dr. Jeff Lee

April 4, 2023

Final exam material review and Q&A session 

Danielle Karakas

Recommended readings or text book

Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.