LMP200H1 – Pathobiology of the Cell
Course description
This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.
We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.
Course coordinator
Office address: 1 King’s College Circle, MSB 6314
Office address: 1 King’s College Circle, MSB 6275
Teaching assistant
Danielle Karakas
danielle.karakas@mail.utoronto.ca
Term |
Winter 2023 |
Lecture location and time |
Friday 3 - 5 pm MSB 3278, Medical Sciences Building |
Tutorial location and time: |
Tuesday 2 - 3 pm BA 2155, Bahen Centre Information Tech, 40 St. George Street |
Office hours |
Contact TA or Course Coordinators |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
- Prerequisite: BIO230H1, PSL300H1
- Exclusions: LMP340H1, LMP363H1, LMP340H1
- Recommended preparation: BCH210H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Midterm exam: 35%
Assignment (due April 8): 30%
Final exam: 35%
See information on Academic Integrity
Schedule
Date |
Title |
Instructor |
---|---|---|
January 13, 2023 |
Mechanisms of cell injury |
|
January 20, 2023 |
Cell adaptation and cell death |
|
January 27, 2023 |
Oxidative stress, ER stress and defenses |
|
February 3, 2023 |
Calcium homeostasis/ signaling/ metabolism |
|
February 10, 2023 |
Ion channels/pumps |
|
February 17, 2023 |
Iron homeostasis/ metabolism and associated diseases |
|
February 24, 2023 |
Reading Week - no class |
|
March 3, 2023 |
Midterm (2 hours) |
|
March 10, 2023 |
Transport through the membrane and |
|
March 17, 2023 |
Protein misfolding, trafficking and |
|
March 25, 2023 |
Protein degradation and associated diseases |
|
March 31, 2023 |
Cell signaling and cancer |
|
April 7, 2023 |
Cytoskeleton and related diseases Final exam |
Tutorials
Date |
Topic |
Instructor |
---|---|---|
January 10, 2023 |
Pathobiology- What and How? |
|
January 17, 2023 |
Histology in a nutshell |
|
January 24, 2023 |
Assignment discussion |
|
January 31, 2023 |
Lecture material review and Q&A session |
Danielle Karakas |
February 7, 2023 |
Structure-function of ion channel and pumps |
|
February 14, 2023 |
Stem cells and developmental biology |
Danielle Karakas |
February 21, 2023 |
Reading break - no tutorial |
|
February 28, 2023 |
Midterm exam material review and Q&A session |
Danielle Karakas |
March 7, 2023 |
Critiquing research papers |
|
March 14, 2023 |
Paper discussion: SARS-CoV-2 |
|
March 21, 2023 |
Lecture material review and Q&A session |
Danielle Karakas |
March 28, 2023 |
Paper discussion: ubiquitin |
|
April 4, 2023 |
Final exam material review and Q&A session |
Danielle Karakas |
Recommended readings or text book
Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.