LMP200H1 – Pathobiology of the Cell

Enrolment is limited to students in the Pathobiology Specialist program.

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.

By the end of the course, you should have a strong foundation in concepts in cellular pathobiology. You will be well prepared for 300-level LMP courses.

Course coordinator

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314

jeff.lee@utoronto.ca

Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275

doug.templeton@utoronto.ca

Teaching Assistant

Kelly Liu

kellylyj.liu@mail.utoronto.ca

Term	Winter 2026
Lecture time	Friday 3 - 5 pm
Tutorial time	Tuesday 2 - 3 pm
Office hours	By appointment

Course details

Hours: 24L/12T
Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
Prerequisite: BIO230H1, PSL300H1
Exclusions: LMP340H1
Recommended preparation: BCH210H1
Credit value: 0.5
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 35 students

Student evaluation

Midterm exam: 35%

Assignment (due April 2, 2026): 30%

Final exam: 35%

Late submissions will incur a 5% penalty per day late.

See information on Academic Integrity

Schedule

Date	Title	Instructor
January 9, 2026	Mechanisms of cell injury	Dr. Doug Templeton
January 16, 2026	Cell adaptation and cell death	Dr. Doug Templeton
January 23, 2026	Oxidative stress, ER stress and defenses	Dr. Doug Templeton
January 30, 2026	Calcium homeostasis/ signaling/ metabolism	Dr. Doug Templeton
February 6, 2026	Ion channels/pumps	Dr. Doug Templeton
February 13, 2026	Iron homeostasis/ metabolism and associated diseases	Dr. Doug Templeton
February 20, 2026	Reading Week - no class
February 27, 2026	Midterm (2 hours)
March 6, 2026	Transport through the membrane and exploitation by pathogens Part I	Dr. Jeff Lee
March 13, 2026	Transport through the membrane- exploitation by pathogens Part II	Dr. Jeff Lee
March 20, 2026	Protein folding, trafficking and proteinopathies	Dr. Jeff Lee
March 27, 2026	Protein degradation and associated diseases	Dr. Jeff Lee
April 6, 2026	Cell signaling and cancer	Dr. Jeff Lee
April 9 - 29, 2026	Final exam period

Tutorials

Date	Topic	Instructor
January 6, 2026	Pathobiology. What and How?	Dr. Doug Templeton
January 13, 2026	Histology in a nutshell	Dr. Doug Templeton
January 20, 2026	Assignment discussion	Dr. Doug Templeton Dr. Jeff Lee
January 27, 2026	Lecture material review and Q&A session	Kelly Liu
February 3, 2026	Structure-function of ion channel and pumps	Dr. Jeff Lee
February 10, 2026	Molecular and cellular mechanisms of chronic hepatitis induced liver cancer HCC	Kelly Liu
February 18, 2025	Reading break - no tutorial
February 26, 2026	Midterm exam material review and Q&A session	Kelly Liu
March 3, 2026	Critiquing research papers	Dr. Doug Templeton Dr. Jeff Lee
March 11, 2025	Paper discussion: viral entry	Dr. Jeff Lee
March 17, 2026	Lecture material review and Q&A session	Kelly Liu
March 24, 2026	Paper discussion: ubiquitin	Dr. Jeff Lee
April 31, 2026	Final exam material review and Q&A session	Kelly Liu