LMP200H1 – Pathobiology of the Cell

Course description

This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.

We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.                                                        

Course coordinator

Dr. Jeffrey E. Lee

Office address: 1 King’s College Circle, MSB 6314


Dr. Doug Templeton

Office address: 1 King’s College Circle, MSB 6275


Teaching assistant

Amanda Mao



 Winter 2024

Lecture time

Friday 3 - 5 pm

Tutorial time: 

Tuesday 2 - 3 pm

Office hours

Fridays 5 - 6 pm

Course details

  • Hours: 24L/12T
  • Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
  • PrerequisiteBIO230H1, PSL300H1
  • ExclusionsLMP340H1LMP363H1, LMP340H1 
  • Recommended preparation: BCH210H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 35 students

Student evaluation

Midterm exam: 35%

Assignment (due April 8): 30%

Final exam: 35%

See information on Academic Integrity





January 13, 2023

Mechanisms of cell injury 

Dr. Doug Templeton

January 20, 2023

Cell adaptation and cell death

Dr. Doug Templeton

January 27, 2023

Oxidative stress, ER stress and defenses

Dr. Doug Templeton

February 3, 2023

Calcium homeostasis/ signaling/ metabolism 

Dr. Doug Templeton

February 10, 2023

Ion channels/pumps

Dr. Doug Templeton

February 17, 2023

Iron homeostasis/ metabolism and associated diseases

Dr. Doug Templeton

February 24, 2023

Reading Week - no class


March 3, 2023

Midterm (2 hours)


March 10, 2023

Transport through the membrane and 
exploitation by pathogens

Dr. Jeff Lee

March 17, 2023

Protein misfolding, trafficking and 

Dr. Jeff Lee

March 25, 2023

Protein degradation and associated diseases

Dr. Jeff Lee

March 31, 2023

Cell signaling and cancer 

Dr. Jeff Lee

April 7, 2023

Cytoskeleton and related diseases

Final exam

Dr. Jeff Lee





January 10, 2023

Pathobiology- What and How?  

Dr. Doug Templeton

January 17, 2023

Histology in a nutshell

Dr. Doug Templeton

January 24, 2023

Assignment discussion

Dr. Doug Templeton

Dr. Jeff Lee

January 31, 2023

Lecture material review and Q&A session

Amanda Mao

February 7, 2023

Structure-function of ion channel and pumps

Dr. Jeff Lee

February 14, 2023

Stem cells and developmental biology

Amanda Mao

February 21, 2023

Reading break - no tutorial


February 28,  2023

Midterm exam material review and Q&A session 

Amanda Mao

March 7, 2023

Critiquing research papers 

Dr. Doug Templeton

Dr. Jeff Lee

March 14, 2023

Paper discussion: SARS-CoV-2 

Dr. Jeff Lee

March 21, 2023

Lecture material review and Q&A session 

Amanda Mao

March 28, 2023

Paper discussion: ubiquitin 

Dr. Jeff Lee

April 4, 2023

Final exam material review and Q&A session 

Amanda Mao

Recommended readings or text book

Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.