Sandip SenGupta

You can connect with Dr. SenGupta on LinkedIn.

Accepting PhD students in collaboration with other Principal Investigators

I am a laboratory physician leader, diagnostic pathologist, medical educator, and clinician scientist with more than 35 years of experience in academic medicine, mostly at Queen's Health Sciences. I was amongst the first cohort of Canadian Certified Physician Executives and served as President of the Canadian Association of Pathologists and President of the Ontario Association of Pathologists. 

My previous medical leadership interests have included population health management and value-based care with a focus on appropriateness of diagnostic laboratory testing.

Research synopsis

As an academic diagnostic pathologist, I have developed a national reputation for expertise in breast pathology. I have participated in several multidisciplinary and multi-institutional research studies in breast cancer molecular biology, epidemiology, and pathology. 

I currently continue to publish, in collaboration with colleagues across Canada, in the field of HER2 testing in breast cancer. 

More recently, I have developed an interest in the potential role of artificial intelligence in pathology, specifically the opportunity to reduce tedious, manual cell counting in tissues so that results for precision medicine can be standardized and simplified.

Selected publications

Elliott BE, Meens JA, SenGupta SK, Louvard D, Arpin M. The membrane cytoskeleton crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res.; 02; 7(3): R365-73, 2005. Contributing author 

Zhao Y, Montminy T, Azad T, Lightbody E, Hao Y, SenGupta SK, Asselin E, Nicol CJB, Yang X. PI3K Regulates YAP/TAZ in Mammary Tumorigenesis through Multiple Signaling Pathways. Molecular Cancer Research 2018. DOI: 10.1158/1541-7786.MCR-17-0593. Contributing author 

Rakovitch E, Nofech-Mozes S, Hanna W, Sutradhar R, Baehner FL, Miller DP, Fong C, Gu S, Tuck A, SenGupta SK, Elavathil L, Jani PA, Bonin M, Chong MC, Slodkowska E, Anderson JM, Cherbavaz DB, Shak S, Paszat L. Omitting radiotherapy after lumpectomy for pure DCIS does not reduce the risk of salvage mastectomy. Breast 2017 Aug 3. Pii: S0960-9776(17)30517-9. Doi: 10.1016/j.breast.2017.07.002. Contributing author 

Rakovitch E, Nofech-Mozes S, Hanna W, Baehner FL, Saskin R, Butler SM, Tuck A, SenGupta SK, Elavathil P, Jani PA, Bonin M, Chang MC, Slodkowska E, Anderson JM, Jamshidian F, Cherbavaz DB. A Population-Based Validation Study of the DCIS Score Predicting Recurrence Risk in Individuals Treated by Breast-Conserving Surgery Alone. Breast Cancer Research and Treatment 2015 152:3464 DOI: 10.1007/s10549-015-3464-6. Contributing author 

Grundy A, Richardson H, Burstyn I, Lohrisch C, SenGupta SK, Lai AS, Lee D, Spinelli JJ, Aronson KJ. Increased risk of breast cancer associated with long-term shift work in Canada. Occup. Environ. Med. doi: 10.1136/oemed-101482, 2013. Contributing author 

Mak H, Naba A, Varma S, Schick C, Day A, SenGupta SK, Arpin M, Elliott BE. Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer; 03; 12/82 (IF:3.01), 2012. Trainee: Co-supervised graduate student. Contributing author 

Woolcott CG, Aronson KJ, Hanna WM, SenGupta SK, McCready DM, Sterns EE, Miller AB. Organochlorines and breast cancer risk by receptor status, tumour size and grade. Cancer Causes and Control; 12(5):395-404, 2001. Trainee: Co-supervised graduate student. Contributing author

Appointments

Professor, Laboratory Medicine and Pathobiology, University of Toronto

Chief of Pathology and Medical Director of Laboratory Medicine, North York General Hospital

Honours and awards

Canadian Certified Physician Executive

Team Leadership Award, Kingston Health Sciences Centre

Healthcare Professional of the Year - Strathmore's Who's Who

Top Pathologist - The Leading Physicians of the World