Deciphering the epigenetic and transcriptional basis of Endothelial Maturation and Homeostasis in health and disease
As part of our Monday seminar series, we are delighted to welcome our speaker:
Dr. Joshua D. Wythe, PhD
Associate Professor, Cardiovascular Research Institute, Department of Molecular Physiology and Biophysics, Baylor College of Medicine
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How to join
An email including Zoom link will be sent to the LMP community.
If you are not part of LMP and wish to join this talk, please contact:
Louella D'Cunha
Speaker: Joshua D. Wythe
Dr. Wythe is currently a tenured associate professor at Baylor College of Medicine (BCM) in Houston, Texas and a member of the Cardiovascular Research Institute, as well as the Dan L. Duncan Comprehensive Cancer Center at BCM. Prior to moving to BCM in late 2014, he was a non-tenure track research scientist at the Gladstone Institute of Cardiovascular Disease at UCSF, where he also completed his postdoctoral fellowship in Dr. Benoit Bruneau's lab (2008-2012). Dr. Wythe performed his graduate studies at the University of Utah with Dean Y. Li (now head of translation research at Merck) (2001-2007), studying angiogenesis, smooth muscle biology, and cardiac development.
His laboratory is focused on identifying the molecular regulators of endothelial specialization in the developing vertebrate embryo, and how this process is altered in disease settings, with a focus on the cerebrovasculature. Through next generation sequencing and informatics, and the use of both murine and zebrafish models, combined with 3D imaging technologies (such as light sheet fluorescent microscopy and micro-CT), they are determining if these developmental mechanisms can be exploited for therapeutic advances in treating diseases featuring abnormal vascular behavior or function in the brain, such as brain arteriovenous malformations, glioma, or CADASIL.
