Residency research

Residents taking part in our Residency Training Programs conduct a wide variety of research during their time with us. Often this research results in publication, including in well-known journals such as Nature and the Lancet.

Here are some examples of what our residents have been achieving whilst completing our pathology programs.

View some videos of residents dicussing their research, or view papers published during their residency by topic below.

Susan Armstrong discusses her involvement in the paper: What’s New in Fibroblastic Tumours

LMP Residents research: Cornelia Thoeni

Rachel Han discusses her involvement in the paper: Lack of Standardization in the Processing and Reporting of Post-Neoadjuvant Breast Cancer Specimens: A Survey of Canadian Pathologists and Pathology Assistants

LMP Residents research: Rachel Han

Niloofar Sina discusses her involvement in the paper: Pitfalls in diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion

LMP Residents research: Niloofar Sina

Cornelia Thoeni discusses her involvement in the paper: Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases

LMP Residents research: Cornelia Thoeni

Autopsy Pathology

Developing a pan-cancer research autopsy programme. J Clin Pathol. Bavi P, Siva M, Abi-Saab T, Chadwick D, Dhani N, Butany J, Joshua AM, Roehrl MH. 2019 Oct;72(10):689-695. doi: 10.1136/jclinpath-2019-205874. Epub 2019 Jul 1.PMID: 31262953 Prashant Bavi, Anatomical Pathology Resident.

Bone and Soft Tissue Pathology

What’s New in Fibroblastic Tumours. Virchows Arch. Armstrong SM, Demicco EG. 2020 Jan;476(1):41-55. doi: 10.1007/s00428-019-02682-x. Epub 2019 Dec 11. Susan Armstrong, Anatomical Pathology Resident.

Pathology Outlines. Armstrong SM, Dickson BC. SMARCA4/brg1. Susan Armstrong, Anatomical Pathology Resident.

Breast pathology

Lack of Standardization in the Processing and Reporting of Post-Neoadjuvant Breast Cancer Specimens: A Survey of Canadian Pathologists and Pathology Assistants. Arch Pathol Lab Med. Han R, Regpala S, Slodkowska E, Nofech-Mozes S, Hanna W, Parra-Herran C, Lu F. 2020 Oct;144(10):1262-1270. Rachel Han, Anatomical Pathology Resident.

Validation of whole slide imaging for evaluation of sentinel lymph nodes in breast carcinoma, USCAP. Hosseini N, Faragalla H, Lu F, Florianova L, Mulligan A-M, Jakate K. 2018. Vancouver, BC. Niloufar Hosseini, Anatomical Pathology Resident.

A case of epithelioid hemangioendothelioma occurring in the post-radiation setting for breast cancer. Genes Chromosomes Cancer. Hahn E, Dickson BC, Gupta AA, Nofech-Mozes S. 2020 Oct 30. doi: 10.1002/gcc.22912. Epub ahead of print. PMID: 33125182. Elan Hahn, Anatomical Pathology Resident.

Analysis of tumor nuclear features using artificial intelligence to predict response to neoadjuvant chemotherapy in high risk breast cancer patients. Breast Cancer Res Treat. Dodington DW, Lagree A, Tabbarah S, Mohebpour M, Sadeghi-Naini A, Tran WT, Lu F. 2021; In press. David Dodington, Anatomical Pathology Resident.

Cardiovascular pathology

Left Ventricular Assist Device Support for Fabry Cardiomyopathy: A Case Series. CJC Open. Kiamanesh O, Moayedi Y, Aleksova N, Posada JD, Gershon A, Seidman MA, et al. October 2020 Ariel Gershon, Anatomical Pathology Resident.

Fatal secondary aortoduodenal fistula diagnosed with postmortem computed tomography angiography. Forensic Sci Med Pathol. Gershon A, Little D, Ball CG, Williams AS. May 2020. Ariel Gershon, Anatomical Pathology Resident.

Do these genes make my heart look fat? Why molecular changes matter in congenital heart disease. Can J Cardiol. Armstrong SM, Seidman MA. 2020 Jul 36(7):997-999. doi: 10.1016/j.cjca.2020.05.020. Epub 2020 May 17. Susan Armstrong, Anatomical Pathology Resident.

Dermatopathology

Pitfalls in the diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion. Sina N, Saeed-Kamil Z, Ghazarian D.J Clin Pathol. 2021 Jan;74(1):7-9. doi: 10.1136/jclinpath-2020-207051. Epub 2020 Oct 13.PMID: 33051287 Review. Niloofar Sina, Anatomical Pathology Resident.

Biologic subtypes of melanoma predict survival benefit of combination anti-PD1 + anti-CTLA4 immune checkpoint blockade versus anti-PD1 monotherapy. Journal for ImmunoTherapy of Cancer. Rose AAN, Armstrong SM, Hogg DW, Butler MO, Saibil SD, Ceballos DPA, Muniz TP, Kelly D, Ghazarian D, King I, Ross K, Spreafico A. Susan Armstrong, Anatomical Pathology Resident.

Gastrointestinal pathology

A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. PLoS Genet. Mederer T, Schmitteckert S, Volz J, Martínez C, Röth R, Thumberger T, Eckstein V, Scheuerer J, Thöni C, Lasitschka F, Carstensen L, Günther P, Holland-Cunz S, Hofstra R, Brosens E, Rosenfeld JA, Schaaf CP, Schriemer D, Ceccherini I, Rusmini M, Tilghman J, Luzón-Toro B, Torroglosa A, Borrego S, Sze-Man Tang C, Garcia-Barceló M, Tam P, Paramasivam N, Bewerunge-Hudler M, De La Torre C, Gretz N, Rappold GA, Romero P, Niesler B. 2020 Nov 5;16(11):e1009106. doi: 10.1371/journal.pgen.1009106. PMID: 33151932. Cornelia Thoeni, Anatomical Pathology Resident.

Comparative expression profiling in the intestine of patients with Giardia-induced postinfectious functional gastrointestinal disorders. Neurogastroenterol Motil. Martínez C, Lasitschka F, Thöni C, Wohlfarth C, Braun A, Granzow M, Röth R, Dizdar V, Rappold GA, Hausken T, Langeland N, Hanevik K, Niesler B. 2020 Sep;32(9):e13868. doi: 10.1111/nmo.13868. Epub 2020 May 11. Cornelia Thoeni, Anatomical Pathology Resident.

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. J Clin Oncol. Mlecnik B, Bifulco C, Bindea G, Marliot F, Lugli A, Lee JJ, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Lafontaine L, Bruni D, Lanzi A, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Paustian C, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Muşină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Fox BA, Pagès F, Galon J. 2020 Nov 1;38(31):3638-3651. doi: 10.1200/JCO.19.03205. Epub 2020 Sep 8.PMID: 32897827 Prashant Bavi, Anatomical Pathology Resident.

A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer. Clin Cancer Res. Romero JM, Grünwald BT, Jang GH, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, Liang SB, Chadwick D, Vyas F, Bronsert P, Khokha R, McGaha TL, Notta F, Ohashi PS, Done SJ, O'Kane GM, Wilson JM, Knox JJ, Connor A, Wang Y, Zogopoulos G, Gallinger S. 2020;26(8):1997‐2010. doi:10.1158/1078-0432.CCR-19-2803 PubMed PMID: 31964786. Prashant Bavi, Anatomical Pathology Resident.

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases. Cancer Cell. Connor AA, Denroche RE, Jang GH, Lemire M, Zhang A, Chan-Seng-Yue M, Wilson G, Grant RC, Merico D, Lungu I, Bartlett JMS, Chadwick D, Liang SB, Eagles J, Mbabaali F, Miller JK, Krzyzanowski P, Armstrong H, Luo X, Jorgensen LGT, Romero JM, Bavi P, Fischer SE, Serra S, Hafezi-Bakhtiari S, Caglar D, Roehrl MHA, Clear S, Hollingsworth MA, Petersen GM, Thayer S, Law CHL, Nanji S, Golan T, Smith AL, Borgida A, Dodd A, Hedley D, Wouters BG, O'Kane GM, Wilson JM, Zogopoulos G, Notta F, Knox JJ, Gallinger S. 2019 Feb 11;35(2):267-282.e7. doi: 10.1016/j.ccell.2018.12.010. Epub 2019 Jan 24. PubMed PMID: 30686769. Prashant Bavi, Anatomical Pathology Resident.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J. 2018 May 26;391(10135):2128-2139. doi: 10.1016/S0140-6736(18)30789-X. Epub 2018 May 10.PMID: 29754777 Prashant Bavi, Anatomical Pathology Resident.

Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases. J Proteomics. Yang Q, Bavi P, Wang JY, Roehrl MH. 2017 Sep 25;168:53-65. doi: 10.1016/j.jprot.2017.06.021. Epub 2017 Jun 29.PMID: 28669815 Prashant Bavi, Anatomical Pathology Resident.

Genitourinary pathology

Case Report. Images in pathology: The *wild*prostate. Human Pathology: Case Reports. Thoeni C, Margolis M, Toi A, Van der Kwast T.; Volume 21, September 2020, 200412. Cornelia Thoeni, Anatomical Pathology Resident.

Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis. J Clin Pathol. Hahn E, Liu SK, Vesprini D, Xu B, Downes MR. 2018;71(11):1023‐1027. doi:10.1136/jclinpath-2018-205404 Elan Hahn, Anatomical Pathology Resident.

Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types. Hum Pathol. Wang C, Hahn E, Slodkowska E, et al. 2018;82:131-139. Angela Wang, Anatomical Pathology Resident.

Prognostic pathological factors in radical cystectomy after neoadjuvant chemotherapy. Histopathology. Brimo F, Downes MR, Jamaspishvili T, Berman D, Barkan GA, Athanazio D, Abro S, Visram K, Yilmaz A, Solanki S, Hahn E, Siemens R, Kassouf W, Trpkov K. 2018;73(5):732-740. doi:10.1111/his.13654 Elan Hahn, Anatomical Pathology Resident.

Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types. Hum Pathol. Wang C, Hahn E, Slodkowska E, et al. 2018;82:131‐139. doi:10.1016/j.humpath.2018.07.024 Elan Hahn, Anatomical Pathology Resident.

Tumour-to-tumour metastasis: a rare case of apparent intratumoural heterogeneity in conventional clear cell renal cell carcinoma. Diagnostic Histopathology. Hahn E, Evans A., 2018;24:220-222. doi:10.1016/j.mpdhp.2018.05.003. Elan Hahn, Anatomical Pathology Resident.

Milk of calcium renal cyst and Liesegang structures, Human Pathology: Case Reports. Bavi P, J Butany, K Khalili, R Chetty, 2019 18, 200336 Prashant Bavi, Anatomical Pathology Resident.

Gynecological pathology

Cytologic features of undifferentiated and dedifferentiated carcinomas of the endometrium. Akbari A-H, Wang L, Soslow R, Murali R. 16 September 2020 Amir Akbari, Anatomical Pathology Resident.

Differentiated exophytic vulvar intraepithelial lesion: Clinicopathologic and molecular analysis documenting its relationship with verrucous carcinoma of the vulva. Akbari A, Pinto A, Amemiya Y, Seth A, Mirkovic J, Parra-Herran C. - 2020, Amir Akbari, Anatomical Pathology Resident.

Androgenetic/Biparental Mosaic/Chimeric Conceptions with a Molar Component: A Diagnostic and Clinical Challenge. Hodgson A, Dube V, Strickland S, Kolomietz E, Noor A, Akbari A, Colgan T, Turashvili G. 2020 Amir Akbari, Anatomical Pathology Resident.

Differentiated exophytic vulvar intraepithelial lesion: Clinicopathologic and molecular analysis documenting its relationship with verrucous carcinoma of the vulva. Akbari A, Pinto A, Amemiya Y, Seth A, Mirkovic J, Parra-Herran C. - 2020, Amir Akbari, Anatomical Pathology Resident.

Hepatobiliary pathology

Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases. Can J Gastroenterol Hepatol. Thoeni C, Waldherr R, Scheuerer J, Schmitteckert S, Roeth R, Niesler B, Cutz E, Flechtenmacher C, Goeppert B, Schirmacher P, Lasitschka F. 2019 Dec. 10;2019:1085717. doi: 10.1155/2019/1085717. Cornelia Thoeni, Anatomical Pathology Resident.

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation. J. Vis. Exp Chen, X. C., Sekhon, M., Ma, X. Z., Manuel, J., Chung, S., He, E., Bartczak, A., Fischer, S., Thoeni, C., Oldani, G., Perciani, C. T., MacParland, S., McGilvray, I. (165), e60628, doi:10.3791/60628 (2020). Cornelia Thoeni, Anatomical Pathology Resident.

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model. ACS Nano. Liu LY, Ma XZ, Ouyang B, Ings DP, Marwah S, Liu J, Chen AY, Gupta R, Manuel J, Chen XC, Gage BK, Cirlan I, Khuu N, Chung S, Camat D, Cheng M, Sekhon M, Zagorovsky K, Abdou Mohamed MA, Thoeni C, Atif J, Echeverri J, Kollmann D, Fischer S, Bader GD, Chan WCW, Michalak TI, McGilvray ID, MacParland SA. 2020 Apr 28;14(4):4698-4715. doi: 10.1021/acsnano.0c00468. Epub 2020 Apr 14. Cornelia Thoeni, Anatomical Pathology Resident.

Hepatocellular adenoma in the paediatric population: Molecular classification and clinical associations. World J Gastroenterol. Hahn E, Putra J. 2020 May 21;26(19):2294-2304. doi: 10.3748/wjg.v26.i19.2294. PMID: 32476794; PMCID: PMC7243640. Elan Hahn, Anatomical Pathology Resident.

Molecular Pathology

Germline-somatic fluidity in guiding patient care. Ann Oncol. Hahn E, Charames GS. 2020 Aug;31(8):1089-1090. doi: 10.1016/j.annonc.2020.04.472. Epub 2020 May 6. PMID: 32387416. Elan Hahn, Anatomical Pathology Resident.

Therapeutic Gene Editing with CRISPR: A Laboratory Medicine Perspective. Clin Lab Med. Hahn E, Hiemenz M. 2020 Jun;40(2):205-219. doi: 10.1016/j.cll.2020.02.008. PMID: 32439069. Elan Hahn, Anatomical Pathology Resident.

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications. Bailey MH, Meyerson WU, Dursi LJ, Wang LB, Dong G, Liang WW, Weerasinghe A, Li S, Li Y, Kelso S; MC3 Working Group; PCAWG novel somatic mutation calling methods working group, Saksena G, Ellrott K, Wendl MC, Wheeler DA, Getz G, Simpson JT, Gerstein MB, Ding L; PCAWG Consortium.. 2020 Sep 21;11(1):4748. doi: 10.1038/s41467-020-18151-y.PMID: 32958763 Prashant Bavi, Anatomical Pathology Resident.

Pan-cancer analysis of whole genomes. Nature. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5. PMID: 32025007 Prashant Bavi, Anatomical Pathology Resident.

Sex differences in oncogenic mutational processes. Nature Communications. Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N; PCAWG Tumour Subtypes and Clinical Translation, Boutros PC; PCAWG Consortium. 2020 Aug 28;11(1):4330. doi: 10.1038/s41467-020-17359-2. PMID: 32859912 Prashant Bavi, Anatomical Pathology Resident.

Neuropathology

A case of disseminated microscopic demyelination with multifocal dystrophic calcification. Neuropathology. Abdollahi M, Gao AF, Munoz DG. 2020 Jun;40(3):308-314. doi: 10.1111/neup.12642. Epub 2020 Mar 3. PMID: 32128889. Maryam Abdollahi, Anatomical Pathology Resident.

Pediatric pathology

Type 1 Choledochal Cyst with Ectopic Pancreas and Septate Gallbladder. Fetal Pediatr Pathol. Akbari AH, Putra J. 2020 Jul 29:1-4. doi: 10.1080/15513815.2020.1797962. PMID: 32723208. Amir Akbari, Anatomical Pathology Resident.

Perinatal Pathology

Renal tubular dysgenesis in a case of Fetus acardius amorphous, accepted for publication in Case Reports in Pathology. C. Thoeni, K. Holzer, J. Leichsenring, C. Porcel, B. K. Straub, HP. Sinn, M. Elsaesser, AL Volckmar, P. Schirmacher, R. Waldherr, F. Lasitschka. 2019. Cornelia Thoeni, Anatomical Pathology Resident.

Technical/Quality

Are serial sections on a slide of significant use in pathologic evaluation of biopsies? USCAP. Hosseini N, Jakate K, Hakim S, Krizova S, Rowsell C, Streutker C. 2020, Los Angeles, CA. Niloufar Hosseini, Anatomical Pathology Resident.