Assistant Professor

Lingxin Zhang

Department of Laboratory Medicine & Pathobiology


Mount Sinai Hospital: Sinai Health
600 University Ave, Department of Pathology and Laboratory Medicine, Toronto, Ontario Canada M5G 1X5
Clinical Interests
Pathology: Bone & Soft Tissue
Appointment Status

Dr. Lingxin Zhang is a Staff Pathologist in the Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and an Assistant Professor in the Department of Laboratory Medicine and Pathobiology, University of Toronto. She obtained her medical degree at Peking University Health Science Center. She is a graduate of the Anatomic and Clinical Pathology Residency Program at Washington University in St. Louis and completed fellowships in Orthopedic Pathology at Hospital for Special Surgery and Oncologic Surgical Pathology at Memorial Sloan-Kettering Cancer Center in New York. She joined faculty at Mount Sinai Hospital in 2020 and focuses on Bone/Soft Tissue and Head and Neck Pathology.

Research Synopsis

My research interests include neoplastic and nonneoplastic diseases of bone/soft tissue and disorders of the ear, nose, throat, and related structures of the head and neck. My past work has been focused on characterization of clinicopathologic features of inflammatory bone disorders, such as subarticular inflammatory pseudoabscesses; identification of molecular features in bone tumors, such as myositis ossificans-like soft tissue aneurysmal bone cysts; and the presence of human-papillomavirus in non-keratinizing squamous cell carcinomas in the upper aerodigestive tract. Our most recent expenditure looks into proteomics of tumors via imaging mass spectrometry, allowing the direct acquisition of spatial distribution of peptides and lipids from tissue sections, and creating images from mass spectra. My future research goal is to seek to identify novel diagnostic biomarkers using exome sequencing and protein expression data and to refine risk stratification schemes for tumors arising in bone/soft tissue and the head and neck region. I also have an interest in transdisciplinary collaborations for radiologic-pathologic correlation in bone disorders and the application of bioinformatics to pathologic diagnosis.

Selected Publications

Yang C, Zhang L, Love-Gregory L, et al. Identification of novel ALK rearrangements in gynecologic clear cell carcinoma. Int J Cancer. 2021;148:459–468. [PMID: 3034056]

Zhang L, Yang C, Pfeifer J, Caprioli R, Judd A, Patterson N, Reyzer M, Norris J, Maluf H. Histopathologic, Immunophenotypic and Proteomics Characteristics of Low-Grade Phyllodes Tumor and Fibroadenoma: More Similarities than Differences. NPJ Breast Cancer. 2020; 6(27). [PMID: 32613078]

Zhang L, Hwang S, Benayed R, Zhu G, Mullaney K, Rios K, Sukhadia P, Agaram N, Zhang Y, Bridge J, Healey J, Athanasian E, Hameed M. Myositis Ossificans-like Soft Tissue Aneurysmal Bone Cyst: A Clinical, Radiological, and Pathological Study of Seven Cases With COL1A1-USP6 Fusion and A Novel ANGPTL2-USP6 Fusion. Modern Pathology. 2020; 33(8):1492-1504. [PMID: 32157177]

Zhang L, Mirza SZ, DiCarlo EF. Subarticular Inflammatory Pseudoabscesses: A Pathologic Study with Clinical Correlation. American Journal of Surgical Pathology. 2020; 44(5):633-640. [PMID: 32294062]

Yang C, Sun L, Zhang L, Zhou L, Zhao M, Peng Y, Niu D, Li Z, Huang X, Kang Q, Jia L, Lai J, Cao D. Diagnostic Utility of SATB2 in Metastatic Krukenberg Tumors of the Ovary: An Immunohistochemical Study of 70 Cases with Comparison to CDX2, CK7, CK20, Chromogranin and Synaptophysin. American Journal of Surgical Pathology. 2018; 42(2):160-171. [PMID: 28914716]

Zhang L, Yang C, Lewis JS, El-Mofty SK, Chernock RD. p16 Expression In Follicular Dendritic Cell Sarcoma: A Potential Mimicker of HPV-related Oropharyngeal Squamous Cell Carcinoma. Human Pathology. 2017; 66:40-47. [PMID: 28554574]

Zhang L, Lewis JS, El-Mofty SK, Gandhi M, and Chernock RD. Nonkeratinizing Squamous Cell Carcinoma in Situ of the Upper Aerodigestive Tract: An HPV-Related Entity. Head and Neck Pathology. 2017; 11(2):152-161 [PMID: 27492445]