Professor  |  Department Chair

Rita Kandel

Department of Laboratory Medicine & Pathobiology - Anatomic Pathology


Sinai Health: Mount Sinai
1 King's College Circle, Rm 6229, Toronto, Ontario Canada M5S 1A8
Research Interests
Molecular & Cell Biology
Clinical Interests
Anatomic Pathology, Bone & Soft Tissue Pathology
Appointment Status

Dr. Rita Kandel is a clinician-scientist and Chief of Pathology and Laboratory Medicine at Mt. Sinai Hospital, Toronto, Canada. She is a Professor in the Department of Laboratory Medicine and Pathobiology, cross-appointed to the Department of Surgery and a member of the Institute of Biomaterials and Biomedical Engineering and Director of Collaborative Program in Musculoskeletal Sciences at the University of Toronto. She is a Fellow of Canadian Academy of Health Sciences.  Rita is a Director of the Bioengineering of Skeletal Tissues Team, which consists of a multidisciplinary group of investigators, including engineers, biologists, stem cell biologists, and clinicians whose work focuses on regenerative medicine.  Her research interest is in the bioengineering of tissues for articular cartilage repair and intervertebral disc replacement. She is an Associate Editor of Cartilage and a member of the Editorial Board of Osteoarthritis and Cartilage. She has published over 200 papers and multiple book chapters.   

Research Synopsis

Dr. Kandel's clinical expertise is in the diagnosis of soft tissue and bone tumors. Her research interest is in regenerative medicine and the musculoskeletal system and the mechanisms regulating tissue repair.   

Our lab leads Bioengineering of Skeletal Tissue Team (BESTT) which consists of a multi-disciplinary group of scientists, engineers, veterinarians, stem cell biologists and physicians working together with the ultimate goal to develop new approaches for the treatment of damaged joints or disc degeneration.

Our program is translational research that uses regenerative medicine to generate musculoskeletal tissues for use as treatments.  We focus on investigating the mechanisms that regulate tissue formation that will ultimately improve the quality of the tissue regenerated.  We use molecular biology, cell biology and proteonomic methods routinely.

Long-term goals:  To engineer tissues in vitro that can be used to repair damaged joints and spine.

Immediate goals:  

  1. Develop models of joint tissues, such as cartilage or intervertebral disc, which will allow for investigation of the mechanisms regulating tissue formation and degradation.
  2. Identify mechanisms regulating tissue formation following cell attachment to biomaterials or under stimulatory conditions such as mechanical stimulation.  
  3. Develop novel biological approaches to cartilage or intervertebral disc repair/replacement.