Dr. Kandel's clinical expertise is in the diagnosis of soft tissue and bone tumors. Her research interest is in regenerative medicine and the musculoskeletal system and the mechanisms regulating tissue repair.
Our lab leads Bioengineering of Skeletal Tissue Team (BESTT) which consists of a multi-disciplinary group of scientists, engineers, veterinarians, stem cell biologists and physicians working together with the ultimate goal to develop new approaches for the treatment of damaged joints or disc degeneration.
Our program is translational research that uses regenerative medicine to generate musculoskeletal tissues for use as treatments. We focus on investigating the mechanisms that regulate tissue formation that will ultimately improve the quality of the tissue regenerated. We use molecular biology, cell biology and proteonomic methods routinely.
Long-term goals: To engineer tissues in vitro that can be used to repair damaged joints and spine.
- Develop models of joint tissues, such as cartilage or intervertebral disc, which will allow for investigation of the mechanisms regulating tissue formation and degradation.
- Identify mechanisms regulating tissue formation following cell attachment to biomaterials or under stimulatory conditions such as mechanical stimulation.
- Develop novel biological approaches to cartilage or intervertebral disc repair/replacement.