Somatic mutations in the endothelium cause brain arteriovenous malformations: from discovery to translation
As part of our Monday seminar series, we are delighted to welcome our speaker:
Talk title: Somatic mutations in the endothelium cause brain arteriovenous malformations: from discovery to translation
Jason Fish, PhD
Senior Scientist, Toronto General Hospital Research Institute
Professor, Department of Laboratory Medicine & Pathobiology, University of Toronto
Hosted By
How to join
The event will be in person only, no need to register.
MSB 2172
Medical Sciences Building
University of Toronto
1 King’s College Circle
Toronto, ON M5S 1A8
If you have any questions about this event, please contact Debb Yorke at lmp.chairadmin@utoronto.ca.
Speaker: Dr. Jason Fish
Dr. Jason Fish completed his PhD at the University of Toronto under the supervision of Dr. Philip Marsden. Here he uncovered a role for epigenetics in gene regulation in blood vessels. This was followed by a postdoctoral fellowship at the Gladstone Institute of Cardiovascular Disease and the University of California San Francisco under the supervision of Dr. Deepak Srivastava. Here, Dr. Fish uncovered a role for microRNAs in regulating the development of the cardiovascular system. Since moving back to Toronto in 2010, Dr. Fish and his team explore the mechanisms of gene regulation in the endothelium in health and disease. His recent work has uncovered how somatic mutations in the endothelium lead to sporadic brain arteriovenous malformations, a leading cause of stroke in young people. His laboratory is uncovering the mechanisms involved and is using this information to design new therapies. Dr. Fish’s laboratory is also determining how chemotherapy affects the vascular system and how altered endothelial cell identity contributes to atherosclerosis. Dr. Fish is currently the president of the North American Vascular Biology Organization and was recently awarded the CIHR Mid-Career Excellence Award in Blood and Blood Vessel Research.