Professor  |  Program Director: MHSc Laboratory Medicine

Avrum Gotlieb

Department of Laboratory Medicine & Pathobiology


UofT campus: Medical Sciences Building (MSB)
1 Kings College Circle, Laboratory Medicine and Pathobiology RM 6275A, Toronto, Ontario Canada M5S 1A8
Research Interests
Cardiovascular, Molecular & Cell Biology
Clinical Interests
Pathology: Cardiovascular, Pathology: Anatomical
Appointment Status

Avrum I. Gotlieb chaired the committee to create the professional graduate program, MHSc in Laboratory Medicine, which was established in May 2020. He was founding Chair of the Department of Laboratory Medicine and Pathobiology (LMP) (1997-2008), Interim Vice Dean, Research and International Relations (2009-10), Acting and Interim Vice Dean, Graduate and Life Sciences Education (2011-2014), Senior Academic Advisor to the Dean (2010-2017), School of Graduate Studies Tenure Assessor (2017-), and Vice Provost, Faculty and Academic Life Search Committee Assessor (2018-). He became Program Director of the MHSc in Laboratory Medicine in May 2020 and is LMP liaison to the Translational Research Program (2018-)

Dr. Gotlieb’s interest in teaching, mentorship and career planning lead to his first career development booklet in 2003, published by the American Society for Investigative Pathology (ASIP) and the Intersociety Council for Pathology Information. He recently published the second edition of his informative career book, “Planning for a Career in Biomedical and Life Sciences; Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building” (Elsevier, 2018).

Dr. Gotlieb is a cardiovascular pathologist and a clinician scientist who had a successful atherosclerosis and vascular biology research laboratory in LMP. He was the past co-Editor of Cardiovascular Pathology (2000-2010), now Associate Editor, and serves on the Editorial Board of The American Journal of Pathology and of Laboratory Investigation, and is a Senior Advisor, Academic Pathology.

Dr. Gotlieb’s academic contributions have been recognized by several awards including the Robbins Distinguished Educator Award (ASIP) and the Distinguished Service Award (Association of Pathology Chairs). He was President of the American Society for Investigative Pathology (2001-2002), and the Society for Cardiovascular Pathology (1997-1999).

He was the Vice President for Science Policy of the Federation of American Societies for Experimental Biology (FASEB) from 2008-2009. He was elected as a Fellow of both the Canadian Academy of Health Sciences and as a Senior Fellow of the American Pathology Chairs where he is involved in mentorship and professional consultations.

Research Synopsis

My research is currently focused on understanding the pathogenesis of common human cardiovascular diseases such as Atherosclerosis and heart valve disease, especially calcific aortic stenosis. 

The work is now focused on utilizing the expertise in the investigation of experimental models of human disease to review the vast and dynamic literature in these conditions. 

The purpose of these in depth reviews is to develop state of the art teaching material to be used by graduate and undergraduate students, medical students and physicians to transfer up to date knowledge to them. The reviews sift through the literature in a critical fashion to identify validated concepts and to look for new trends emerging in understanding pathogenesis. 

Selected Publications

Bonafiglia QA, Bendeck M, Gotlieb AI. Vascular pathobiology: Atherosclerosis and large vessel disease In Cardiovascular Pathology, ed Buja M, Butany J. Fifth Edition. Elsevier, 2022. Pages 265  - 305.

Tinajero MG, Gotlieb AI, Recent Developments in Vascular Adventitial Pathobiology: The Dynamic Adventitia as a Complex Regulator of Vascular Disease, Am J Pathol. 2020 Mar;190(3):520-534. doi: 10.1016/j.ajpath.2019.10.021. 

Gotlieb AI, Cardiovascular pathologists in translation research, Cardiovasc Pathol. 2021 Sep-Oct;54:107369. doi: 10.1016/j.carpath.2021.107369

Bailey D.N., Buja, M., Gorstein, F., Gotlieb, A.I., Green, R., Kane, A., Lipscomb, M.F., Sanfilippo, F. Life After Being a Pathology Department Chair III: Reflections on the “Afterlife”. Academic Pathology 6, 2019

Bailey D.N., Cohen, S., Gotlieb, A.I. Lipscomb MF. What advice do pathology chairs seek from former pathology chairs. Academic Pathology 5, 2018.

Gotlieb A.I., Liu A.C., McManus B., Allard M.F., Yanagawa R. Chapter 8 Blood Vessels and Hemodynamic Disorders. Principles of Rubin’s Pathology, 7th ed, Rubin E Reisner HM, Wolters Klumer, 2019. 224-260

Planning for a Career in Biomedical and Life Sciences; Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building. 2nd edit. Gotlieb, A.I. Elsevier, 2018.

Gotlieb A.I. Molecular Basis of Cardiovascular Disease, in Molecular Pathology; The Molecular Basis of Human Disease, 2nd ed. Coleman W.B. and Tsongalis G.J. Elsevier 2018. P. 183- 272.

Templeton D., Gotlieb AI. Undergraduate Specialist Program in Pathobiology at the University of Toronto. Academic Pathology 4, 1-6, 2017.

Schoen FJ., Gotlieb AI. Heart valve health, disease, replacement, and repair: a 25-year cardiovascular pathology perspective. Cardiovascular Pathology 25, 341-352, 2016.