Professor  |  Program Director: MHSc Laboratory Medicine

Avrum Gotlieb

Department of Laboratory Medicine & Pathobiology


Medical Sciences Building (MSB)
1 Kings College Circle, Laboratory Medicine and Pathobiology RM 6275A, Toronto, Ontario Canada M5S 1A8
Research Interests
Cardiovascular, Molecular & Cell Biology
Clinical Interests
Anatomic Pathology, Cardiovascular Pathology
Appointment Status

Avrum I. Gotlieb is Chair, Advisory Committee, Translational Research Program (TRP) in Health Science and Program Coordinator of the proposal to establish a new professional MHSc in Laboratory Medicine. He was founding Chair of the Department of Laboratory Medicine and Pathobiology (LMP) (1997-2008), Interim Vice Dean, Research and International Relations (2009-10), Acting and Interim Vice Dean, Graduate and Life Sciences Education (2011-2014), Senior Academic Advisor to the Dean (2010-2017), School of Graduate Studies Tenure Assessor (2017-), and Vice Provost Faculty and Academic Life Search Committee Assessor (2018-).

Dr. Gotlieb’s interest in teaching, mentorship and career planning lead to his first career development booklet in 2003, “The Road to Becoming a Biomedical Physician Scientist in Pathology and Laboratory Medicine”, published by the American Society for Investigative Pathology (ASIP) and the Intersociety Council for Pathology Information.

He has presented career talks at national and international scientific venues and recently published the second edition of his career book, “Planning for a Career in Biomedical and Life Sciences; Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building” (Elsevier, 2018).

Dr. Gotlieb is a clinician scientist who had a successful atherosclerosis and vascular biology research laboratory in LMP. He was the past co-Editor of Cardiovascular Pathology (2000-2010), now Associate Editor, serves on the Editorial Board of The American Journal of Pathology and of Laboratory Investigation, and is a Senior Advisor, Academic Pathology.

Dr. Gotlieb’s academic contributions have been recognized by several awards including the Robbins Distinguished Educator Award (ASIP) and the Distinguished Service Award (Association of Pathology Chairs). He was President of the American Society for Investigative Pathology (2001-2002), and the Society for Cardiovascular Pathology (1997-1999).

He was the Vice President for Science Policy of the Federation of American Societies for Experimental Biology (FASEB) from 2008-2009. He was elected as a Fellow of both the Canadian Academy of Health Sciences and as a Senior Fellow of the American Pathology Chairs where he is involved in mentorship and professional consultations.


Research Synopsis

My research is currently focused on understanding the pathogenesis of common human cardiovascular diseases such as Atherosclerosis and heart valve disease, especially calcific aortic stenosis. 

The work is now focused on utilizing the expertise in the investigation of experimental models of human disease to review the vast and dynamic literature in these conditions. 

The purpose of these in depth reviews is to develop state of the art teaching material to be used by graduate and undergraduate students, medical students and physicians to transfer up to date knowledge to them. The reviews sift through the literature in a critical fashion to identify validated concepts and to look for new trends emerging in understanding pathogenesis. 

The focus is primarily on understanding the cell and molecular biology of the disease conditions and the influence of physical forces on regulating these processes. The emphasis is on the cells in the normal and diseased tissue and how these cells maintain normal physiologic conditions and then undergo transformations to regulate the pathological states that are found in disease.

Recent Publications

Selected list of publications

Bailey D.N., Buja, M., Gorstein, F., Gotlieb, A.I., Green, R., Kane, A., Lipscomb, M.F., Sanfilippo, F. Life After Being a Pathology Department Chair III: Reflections on the “Afterlife”. Academic Pathology (in press)

Bailey D.N., Cohen, S., Gotlieb, A.I. Lipscomb MF. What advice do pathology chairs seek from former pathology chairs. Academic Pathology 2019.

Gotlieb A.I., Liu A.C., McManus B., Allard M.F., Yanagawa R. Chapter 8 Blood Vessels and Hemodynamic Disorders. Principles of Rubin’s Pathology, 7th ed, Rubin E Reisner HM, Wolters Klumer, 2019. 224-260

Planning for a Career in Biomedical and Life Sciences; Learn to Navigate a Tough Research Culture by Harnessing the Power of Career Building. 2nd edit. Gotlieb, A.I. Elsevier, 2018.

Gotlieb A.I. Molecular Basis of Cardiovascular Disease, in Molecular Pathology; The Molecular Basis of Human Disease, 2nd ed. Coleman W.B. and Tsongalis G.J. Elsevier 2018. P. 183- 272.

Templeton D., Gotlieb AI. Undergraduate Specialist Program in Pathobiology at the University of Toronto. Academic Pathology 4, 1-6, 2017.

Schoen FJ., Gotlieb AI. Heart valve health, disease, replacement, and repair: a 25-year cardiovascular pathology perspective. Cardiovascular Pathology 25, 341-352, 2016.

Xu S, Bendeck M, Gotlieb AI. Vascular pathobiology: Atherosclerosis and large vessel disease In Cardiovascular Pathology, ed Buja M, Butany J. Fourth Edition. Elsevier, 2016. P. 85-124.