Rashmi Shivani Goswami
BSc (Hon), BSc (Med), MD, FRCPC, PhD, DABP, FCAP
Dr. Goswami obtained her undergraduate degrees in Genetics and Medical Microbiology from the University of Manitoba and her undergraduate medical degree from the University of Toronto. She subsequently completed her residency in Anatomical Pathology at McGill University.
She returned to the University of Toronto to complete her PhD on microRNAs in the prognosis of mantle cell lymphoma. She went on to obtain clinical subspecialty training in Hematopathology and Molecular Genetic Pathology at the Vancouver General Hospital/British Columbia Cancer Agency and MD Anderson Cancer Center, and holds U.S. board certification in both subspecialties.
Dr. Goswami currently works at the University Health Network as a staff hematopathologist and is an Assistant Professor in the Department of Laboratory Medicine and Pathobiology.
Research Synopsis
Primary research interests include:
- the application of molecular techniques to assist in the diagnosis and prognosis of solid and hematologic tumours
- understanding the genetic and epigenetic landscape of leukemias and lymphomas to determine its impact on disease pathogenesis.
Recent Publications
Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myeloproliferative neoplasms. Mehrotra M, Luthra R, Singh RR, Barkoh BA, Galbincea J, Mehta P, Goswami RS, Jabbar KJ, Loghavi S, Medeiros LJ, Verstovsek S, Patel KP. Am J Clin Pathol. 2015 Nov;144(5):746-55.
Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies. Chen H, Luthra R, Goswami RS, Singh RR, Roy-Chowdhuri S. Cancers (Basel). 2015 Aug 28;7(3):1699-715. doi: 10.3390/cancers7030859. Review.
Factors affecting the success of next-generation sequencing in cytology specimens. Roy-Chowdhuri S, Goswami RS, Chen H, Patel KP, Routbort MJ, Singh RR, Broaddus RR, Barkoh BA, Manekia J, Yao H, Medeiros LJ, Staerkel G, Luthra R, Stewart J. Cancer Cytopathol. 2015 Nov;123(11):659-68.
Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma--is it necessary? Ok CY, Ye Q, Li L, Manyam GC, Deng L, Goswami RR, Wang X, Montes-Moreno S, Visco C, Tzankov A, Dybkaer K, Zhang L, Abramson J, Sohani AR, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Zhang S, Parsons BM, Xu M, Møller MB, Winter JN, Piris MA, Xu-Monette ZY, Medeiros LJ, Young KH. Oncotarget. 2015 Jun 10;6(16):13933-45.
Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant. Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ. Am J Clin Pathol. 2015 Jul;144(1):78-86.
Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors. Goswami RS, Patel KP, Singh RR, Meric-Bernstam F, Kopetz ES, Subbiah V, Alvarez RH, Davies MA, Jabbar KJ, Roy-Chowdhuri S, Lazar AJ, Medeiros LJ, Broaddus RR, Luthra R, Routbort MJ. Clin Cancer Res. 2015 Jun 1;21(11):2644-51.
Comparison of next-generation sequencing mutation profiling with BRAF and IDH1 mutation-specific immunohistochemistry. Jabbar KJ, Luthra R, Patel KP, Singh RR, Goswami R, Aldape KD, Medeiros LJ, Routbort MJ. Am J Surg Pathol. 2015 Apr;39(4):454-61.
Isolated +15 in bone marrow: disease-associated or a benign finding? Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G. Leuk Res. 2015 Jan;39(1):72-6.
Performance evaluation of a dynamic telepathology system (Panoptiq™) in the morphologic assessment of peripheral blood film abnormalities. Goswami R, Pi D, Pal J, Cheng K, Hudoba De Badyn M. Int J Lab Hematol. 2015 Jun;37(3):365-71.
Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis? Cervigne NK, Machado J, Goswami RS, Sadikovic B, Bradley G, Perez-Ordonez B, Galloni NN, Gilbert R, Gullane P, Irish JC, Jurisica I, Reis PP, Kamel-Reid S. Hum Mol Genet. 2014 May 15;23(10):2618-28.
MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. Goswami RS, Atenafu EG, Xuan Y, Waldron L, Reis PP, Sun T, Datti A, Xu W, Kuruvilla J, Good DJ, Lai R, Church AJ, Lam WS, Baetz T, Lebrun DP, Sehn LH, Farinha P, Jurisica I, Bailey DJ, Gascoyne RD, Crump M, Kamel-Reid S. J Clin Oncol. 2013 Aug 10;31(23):2903-11. doi: 10.1200/JCO.2012.45.3050. Epub 2013 Jul 8.
Guidelines for the review of pathology in the research context. Duggan MA, Goswami R, Magliocco AM, Burnier M, Sidhu D; Canadian Association of Pathologists (Association Canadienne des Pathologistes) Working Group. Surgery. 2013 Jul;154(1):111-5.
mRNA transcript quantification in archival samples using multiplexed, color-coded probes. Reis PP, Waldron L, Goswami RS, Xu W, Xuan Y, Perez-Ordonez B, Gullane P, Irish J, Jurisica I, Kamel-Reid S. BMC Biotechnol. 2011 May 9;11:46.
Optimization and analysis of a quantitative real-time PCR-based technique to determine microRNA expression in formalin-fixed paraffin-embedded samples. Goswami RS, Waldron L, Machado J, Cervigne NK, Xu W, Reis PP, Bailey DJ, Jurisica I, Crump MR, Kamel-Reid S. BMC Biotechnol. 2010 Jun 23;10:47.
microRNA evaluation of unknown primary lesions in the head and neck. Barker EV, Cervigne NK, Reis PP, Goswami RS, Xu W, Weinreb I, Irish JC, Kamel-Reid S. Mol Cancer. 2009 Dec 23;8:127.