Professor  |  Co-Vice Chair, Wellness, Inclusion, Diversity and Equity (WIDE)

Isabelle Aubert

Department of Laboratory Medicine & Pathobiology


Sunnybrook Health Science Centre
2075 Bayview Ave., S-112 Res Building, Toronto, Ontario Canada M4N 3M5
Research Interests
Brain & Neuroscience
Appointment Status

Dr. Aubert obtained her PhD in neurosciences at McGill University, Montréal, Canada under the supervision of Dr. Rémi Quirion and Dr. Serge Gauthier. Her doctoral work focused on the plasticity of cholinergic systems in Alzheimer’s and Parkinson’s diseases, as well as during normal brain development and aging.

She completed her post-doctoral training as a Medical Research Council (MRC) Fellow at the Salk Institute for Biological Studies in San Diego, California with Dr. Fred H. Gage. Her work focused on gene therapy, neurotrophins, cholinergic systems and axonal regeneration.

Dr. Aubert is a Professor at the University of Toronto, Temerty Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, and a Tier 1 Canada Research Chair in Brain Repair and Regeneration. As a Senior Scientist at Sunnybrook Research Institute, she is part of the Centre for Research in Image-Guided Therapeutics, Centre for Excellence in Focused Ultrasound and The Harquail Centre for Neuromodulation.

The Brain Repair Group, led by Dr. Isabelle Aubert, focuses on developing therapies to stop neurodegeneration and promote regeneration under pathological conditions found in cases of Alzheimer's disease.

Dr. Aubert leads the LMP Wellness, Inclusion, Diversity and Equity (WIDE) committee.

Research Synopsis

My research program focuses on therapeutic approaches for Alzheimer disease, the most common and untreatable neurodegenerative disorders. I am developing drug and gene therapies to protect brain health and function by halting degeneration, as well as promoting repair and regeneration in models of Alzheimer disease.

My team is exploring the use of transcranial focused ultrasound, guided by MRI, to modulate the blood-brain barrier, deliver therapeutics, reduce pathology and increase neuronal and glial plasticity.

I'd like to thank all my collaborators and trainees for all their work in enabling this research.

View videos about this research by masters student Hang Yu.

Selected papers

For the latest papers from Isabelle Aubert, see her profile on Google Scholar

Honours and Awards

Tier 1 Canada Research Chair (CRC) in Brain Repair and Regeneration (2019)

News from the Aubert Lab