LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore  biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.

Adriana.Krizova@unityhealth.to

Teaching assistant

Scott Ryall

scott.ryall@mail.utoronto.ca

Term

 Fall 2021

Class location and time

Tuesday 1:00-3:00 pm; MS2172

Office hours

Contact TA or instructors

Course details

  • Hours: 24L
  • Prerequisite: BIO230H1, CHM247H1/​ CHM249H1
  • Exclusions: LMP340H1/LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 142 students

Student evaluation

In-class mid-term: 40%

Final exam: 60%

See information on Academic Integrity

Schedule

Dates TBC

Topic

 

Introduction

 

Response of the Cell and Tissue to Injury

 

Response of the Cell and Tissue to Injury

 

Response of the Cell and Tissue to Injury

 

Cell Injury and Cell Death – Mechanisms

 

Cell Injury and Cell Death – Mechanisms

 

Apoptosis

 

Acute Inflammation and Innate Immune Response

 

Acute Inflammation and Innate Immune Response

 

Chronic Inflammation and Adaptive Immune Response

 

Chronic Inflammation and Adaptive Immune Response

 

Immunopathology

 

Immunopathology

 

Mid-term test

 

Autoimmune diseases and testing methods

 

Neoplasia

 

Neoplasia

No Class

Fall reading week

 

Introduction to Forensic Pathobiology

 

Responses of the Gastrointestinal Tract

 

Responses of the Kidney and Urinary Bladder

 

Responses of the Respiratory Tract

 

Pathobiology of Breast Diseases

 

Responses of the Brain

 

Responses of the Myocardium

 

Final Exam

Recommended readings or text book

Basic Pathology (latest edition), by Kumar, Cotran and Robbins

Pathologic Basis of Disease (latest Edition), by Kumar, Abbas & Fausto OR

Pathology (latest edition), by Rubin & Farber