LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.

Adriana.Krizova@unityhealth.to

Teaching assistant

Scott Ryall

scott.ryall@mail.utoronto.ca

Term	Fall 2021
Class location and time	Tuesday 1:00-3:00 pm; MS2172
Office hours	Contact TA or instructors

Course details

Hours: 24L
Prerequisite: BIO230H1, CHM247H1/ CHM249H1
Exclusions: LMP340H1/LMP350H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 142 students

Student evaluation

In-class mid-term: 40%

Final exam: 60%

See information on Academic Integrity

Schedule

Dates TBC	Topic
	Introduction
	Response of the Cell and Tissue to Injury
	Response of the Cell and Tissue to Injury
	Response of the Cell and Tissue to Injury
	Cell Injury and Cell Death – Mechanisms
	Cell Injury and Cell Death – Mechanisms
	Apoptosis
	Acute Inflammation and Innate Immune Response
	Acute Inflammation and Innate Immune Response
	Chronic Inflammation and Adaptive Immune Response
	Chronic Inflammation and Adaptive Immune Response
	Immunopathology
	Immunopathology
	Mid-term test
	Autoimmune diseases and testing methods
	Neoplasia
	Neoplasia
No Class	Fall reading week
	Introduction to Forensic Pathobiology
	Responses of the Gastrointestinal Tract
	Responses of the Kidney and Urinary Bladder
	Responses of the Respiratory Tract
	Pathobiology of Breast Diseases
	Responses of the Brain
	Responses of the Myocardium
	Final Exam