LMP363H1 - Principles of Pathobiology 24L
Course description
Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.
The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.
The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore biochemical and molecular mechanisms.
We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.
Course coordinator
Office address: St. Michael’s Hospital, 30 Bond St.
Adriana.Krizova@unityhealth.to
Teaching assistant
Karen Fang
Term |
Fall 2022 |
Class time |
Tuesday, 1 pm - 3 pm |
Office hours |
Appointments scheduled with students as needed by e-mail |
Course details
- Hours: 24L
- Prerequisite: BIO230H1, CHM247H1/ CHM249H1
- Exclusions: LMP310H1 and LMP320H1
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 142 students
Student evaluation
Mid-term test: 40%
Final exam: 60%
See information on Academic Integrity
Schedule - Fall 2022
Dates |
Topic |
|
---|---|---|
September 13 |
Introduction Response of the Cell and Tissue to Injury |
|
September 20 |
Response of the Cell and Tissue to Injury |
|
September 27 |
Cell Injury and Cell Death – Mechanisms Apoptosis |
|
October 4 |
Acute Inflammation and Innate Immune Response |
Dr. Lee |
October 11 |
Chronic Inflammation and Adaptive Immune Response |
Dr. Lee |
October 18 |
Immunopathology |
Dr. Lee |
October 25 |
Mid-term test - 1 hour Introduction to Neoplasia |
|
November 1 |
Cancers associated with infectious agents Inherited predispositions to cancer |
Dr. Wu |
November 7 - 11 |
Reading week, no classes |
|
November 15 |
Responses of the Respiratory Tract Responses of the Myocardium |
|
November 22 |
Responses of the Brain Responses of the Gastrointestinal Tract |
|
November 29 |
Pathobiology of Selected Diseases in Autopsy Pathology Pathobiology of Forensic Pathology |
|
December 6 |
Responses of the Genitourinary Tract |
|
TBD |
Final Exam |
Recommended readings or text book
Course notes available on the U of T Blackboard.
Basic Pathology (latest edition), by Kumar, Cotran and Robbins
Pathologic Basis of Disease (latest Edition), by Kumar, Abbas & Fausto
OR
Pathology (latest edition), by Rubin & Farber