LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore  biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.


Teaching assistant

Karen Fang



 Fall 2022

Class time

Tuesday, 1 pm - 3 pm

Office hours

Appointments scheduled with students as needed by e-mail

Course details

  • Hours: 24L
  • Prerequisite: BIO230H1, CHM247H1/​ CHM249H1
  • Exclusions: LMP310H1 and LMP320H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 142 students

Student evaluation

Mid-term test: 40%

Final exam: 60%

See information on Academic Integrity

Schedule - Fall 2022




September 13


Response of the Cell and Tissue to Injury

Dr. Douglas Templeton

September 20

Response of the Cell and Tissue to Injury

Dr. Douglas Templeton

September 27

Cell Injury and Cell Death – Mechanisms


Dr. Douglas Templeton

October 4

Acute Inflammation and Innate Immune Response

Dr. Lee

October 11

Chronic Inflammation and Adaptive Immune Response

Dr. Lee

October 18


Dr. Lee

October 25

Mid-term test - 1 hour

Introduction to Neoplasia

Dr. Adriana Krizova 

November 1

Cancers associated with infectious agents 

Inherited predispositions to cancer

Dr. Hala Faragalla 

Dr. Wu

November 7 - 11

Reading week, no classes


November 15

Responses of the Respiratory Tract

Responses of the Myocardium

Dr. Valerie Wallace 

Dr. Jagdish Butany

November 22

Responses of the Brain 

Responses of the Gastrointestinal Tract

Dr. Lili-Naz Hazrati

Dr. Sara Hafezi Bakhtiari

November 29

Pathobiology of Selected Diseases in Autopsy Pathology

Pathobiology of Forensic Pathology

Dr. Magdaleni Bellis 

Dr. Andrew Williams

December 6

Responses of the Genitourinary Tract

Dr. Rola Saleeb


Final Exam


Recommended readings or text book

Course notes available on the U of T Blackboard.     

Basic Pathology (latest edition), by Kumar, Cotran and Robbins

Pathologic Basis of Disease (latest Edition), by Kumar, Abbas & Fausto


Pathology (latest edition), by Rubin & Farber