LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.

Adriana.Krizova@unityhealth.to

Teaching assistant

Karen Fang

k.fang@mail.utoronto.ca

Term	Fall 2022
Class time	Tuesday, 1 pm - 3 pm
Office hours	Appointments scheduled with students as needed by e-mail

Course details

Hours: 24L
Prerequisite: BIO230H1, CHM247H1/ CHM249H1
Exclusions: LMP310H1 and LMP320H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 142 students

Student evaluation

Mid-term test: 40%

Final exam: 60%

See information on Academic Integrity

Schedule - Fall 2022

Dates	Topic
September 13	Introduction Response of the Cell and Tissue to Injury	Dr. Douglas Templeton
September 20	Response of the Cell and Tissue to Injury	Dr. Douglas Templeton
September 27	Cell Injury and Cell Death – Mechanisms Apoptosis	Dr. Douglas Templeton
October 4	Acute Inflammation and Innate Immune Response	Dr. Lee
October 11	Chronic Inflammation and Adaptive Immune Response	Dr. Lee
October 18	Immunopathology	Dr. Lee
October 25	Mid-term test - 1 hour Introduction to Neoplasia	Dr. Adriana Krizova
November 1	Cancers associated with infectious agents Inherited predispositions to cancer	Dr. Hala Faragalla Dr. Wu
November 7 - 11	Reading week, no classes
November 15	Responses of the Respiratory Tract Responses of the Myocardium	Dr. Valerie Wallace Dr. Jagdish Butany
November 22	Responses of the Brain Responses of the Gastrointestinal Tract	Dr. Lili-Naz Hazrati Dr. Sara Hafezi Bakhtiari
November 29	Pathobiology of Selected Diseases in Autopsy Pathology Pathobiology of Forensic Pathology	Dr. Magdaleni Bellis Dr. Andrew Williams
December 6	Responses of the Genitourinary Tract	Dr. Rola Saleeb
TBD	Final Exam