LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore  biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.

Adriana.Krizova@unityhealth.to

Teaching assistant

Scott Ryall

scott.ryall@mail.utoronto.ca

Term  Fall 2021
Class location and time

Tuesday 1:00-3:00 pm; MS2172

Office hours Contact TA or instructors

Course details

  • Hours: 24L
  • Prerequisite: BIO230H1, CHM247H1/​ CHM249H1
  • Exclusions: LMP340H1/LMP350H1
  • Distribution requirements: Science
  • Breadth requirement: Living Things and Their Environment (4)
  • Enrolment limits: 142 students

Student evaluation

In-class mid-term: 40%

Final exam: 60%

See information on Academic Integrity

 

Schedule

Dates TBC Topic
  Introduction
  Response of the Cell and Tissue to Injury
  Response of the Cell and Tissue to Injury
  Response of the Cell and Tissue to Injury
  Cell Injury and Cell Death – Mechanisms
  Cell Injury and Cell Death – Mechanisms
  Apoptosis
  Acute Inflammation and Innate Immune Response
  Acute Inflammation and Innate Immune Response
  Chronic Inflammation and Adaptive Immune Response
  Chronic Inflammation and Adaptive Immune Response
  Immunopathology
  Immunopathology
  Mid-term test
  Autoimmune diseases and testing methods
  Neoplasia
  Neoplasia
No Class Fall reading week
  Introduction to Forensic Pathobiology
  Responses of the Gastrointestinal Tract
  Responses of the Kidney and Urinary Bladder
  Responses of the Respiratory Tract
  Pathobiology of Breast Diseases
  Responses of the Brain
  Responses of the Myocardium
  Final Exam

Recommended readings or text book

Basic Pathology (latest edition), by Kumar, Cotran and Robbins

Pathologic Basis of Disease (latest Edition), by Kumar, Abbas & Fausto OR

Pathology (latest edition), by Rubin & Farber