LMP363H1 - Principles of Pathobiology 24L

Course description

Pathological changes brought on by foreign compounds; mechanisms of pathologic, toxic and carcinogenic change.

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Adriana Krizova

Office address: St. Michael’s Hospital, 30 Bond St.

Adriana.Krizova@unityhealth.to

Teaching assistant

June Li

silvr.li@mail.utoronto.ca

Term

Fall 2021

Class location and time

Tuesday 1:00 - 3:00 pm

MS3154

Office hours

Contact TA or instructors

Course details

Hours: 24L
Prerequisite: BIO230H1, CHM247H1/ CHM249H1
Exclusions: LMP340H1/LMP350H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 142 students

Student evaluation

Mid-term test: 40%

Final exam: 60%

See information on Academic Integrity

Schedule - Fall 2021

Dates	Topic
September 14	Introduction Response of the Cell and Tissue to Injury	Dr. Douglas Templeton
September 21	Response of the Cell and Tissue to Injury	Dr. Douglas Templeton
September 28	Cell Injury and Cell Death – Mechanisms Apoptosis	Dr. Douglas Templeton
October 5	Acute Inflammation and Innate Immune Response	Dr. Jeff Lee
October 12	Chronic Inflammation and Adaptive Immune Response	Dr. Jeff Lee
October 19	Immunopathology	Dr. Jeff Lee
October 26	Mid-term test - 1 hour Introduction to Neoplasia	Dr. Krizova
November 2	Cancers associated with infectious agents Inherited predispositions to cancer	Dr. Hala Faragalla Dr. Wu
November 8 - 12	Reading week, no classes
November 16	Responses of the Respiratory Tract Responses of the Myocardium	Dr. Valerie Wallace Dr. Jagdish Butany
November 23	Responses of the Brain Responses of the Gastrointestinal Tract	Dr. Lili-Naz Hazrati Dr. Sara Hafezi Bakhtiari
November 30	Pathobiology of Selected Diseases in Autopsy Pathology Pathobiology of Forensic Pathology	Dr. Magdaleni Bellis Dr. Andrew Williams
December 7	Responses of the Genitourinary Tract	Dr. Rola Saleeb
TBC	Final Exam