Lei Fu
PhD, DABCC, FADLM, FCACB
Research synopsis
- Study the impact of genetic variations on drug metabolism and the clinical applications of pharmacogenetics.
- Develop bioinformatics tools for next generation sequencing data analysis and pre-emptive pharmacogenetic testing.
- Study the association of genetic variations with vitamin D metabolism and their clinical impact.
- Evaluation, clinical validation and implementation of biomarkers for preeclampsia, and other conditions related to maternal fetal health.
- Quality improvement in laboratory testing in clinical chemistry and molecular diagnostics
Selected publications
Nir Melamed, John Kingdom, Lei Fu, Paul M. Yip, Isabel Arruda_Caycho, Dini Hui, Michelle Hladunewich. Predictive and diagnostic value of the angiogenic proteins in patients with chronic kidney disease. Hypertension. 2024, Aug 20. doi: 10.1161/HYPERTENSIONAHA.124.23411. Online ahead of print.
David Yu Yuan, Jun Hyuk Park, Zhenyu Li, Rohan Thomas, David M. Hwang and Lei Fu. A new cloud-native tool for pharmacogenetic analysis. Genes. 2024, 15(3), 352. https://doi.org/10.3390/genes15030352
Betty Y. L. Wong, Zhenyu Li, Michael Jonathon Raphael, Carlo De Angelis, David M. Hwang, and Lei Fu. Developing DPYD Genotyping Method for Personalized Fluoropyrimidines Therapy. Journal of Applied Laboratory Medicine 2024, 9(2):295-304. doi: 10.1093/jalm/jfad092 PMID: 38084968.
Jessica Miller, Victoria Higgins, Annie Ren, Samantha Logan, Paul M. Yip, and Lei Fu. Advances in Preeclampsia Testing. Advances in Clinical chemistry (Book series), 2023:117:103-161. doi: 10.1016/bs.acc.2023.08.004. PMID:37973318.
Lei Fu, Betty YL Wong, Zhenyu Li, Rashida Williams, Bonnie Lee, Jessica Miller, Thomas O Carpenter, David EC Cole. Genetic variants int eh vitamin D pathway and their association with vitamin D metabolite levels: detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood. Journal of Steroid Biochemistry and Molecular Biology 2023, 233:106369. doi: 10.1016/j.jsbmb.2023.106369. PMID: 37490983.
Angela W.S. Fung, Kenneth I. Shulman, Danijela Konforte, Hilde Vandenberghe, Julia Stemp, Victoria R. Yuan, Paul M. Yip, Lei Fu. Age-stratified lithium therapeutic ranges for older adults with bipolar disorder - From awareness to an action plan. EJIFCC. 2023 Jul 10;34(2):153-166. eCollection 2023 Jul. [electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)]
Jessica J Miller, Victoria Higgins, Nir Melamed, Michelle Hladunewich, Paul M. Yip, Lei Fu. Clinical validation of the sFlt-1:PlGF ratio as a biomarker for pre-eclampsia diagnosis in a high-risk obstetrics unit. The Journal of Applied Laboratory Medicine 2023 8:3, 457-468 doi: 10.1093/jalm/jfad003.
Victoria Higgins, Liyan Ma, Bonny Lem Ragosnig, Nir Melamed, Michelle Hladunewich, Tim James, Joao Leite, Mary Rozmanc, Jon Barrett, Arthur Zaltz, Paul M. Yip, Lei Fu. Analytical Performance and Quality Indicators of Fully Automated Immunoassays for sFlt-1 and PlGF. The Journal of Applied Laboratory Medicine 2022 7:02, 555-567.
Lei Fu, Chad R. Borges, Douglas S. Rehder, Betty Y.L. Wong, Rashida Williams, Thomas O. Carpenter, David E.C. Cole. Characterization of additional vitamin D binding protein variants. Journal of Steroid Biochemistry and Molecular Biology 2016; 159:54-59.
Lei Fu, Francisco Yun, Marko Oczak, Betty Wong, Reinhold Vieth and David EC Cole. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clinical Biochemistry 2009, 42:1174-1177.
Appointments
Clinical Biochemist, Precision Diagnostics and Therapeutics Program (Laboratory Medicine), Sunnybrook Health Sciences Centre and Sunnybrook Research Institute
Assistant Professor and graduate faculty, Department of Laboratory Medicine & Pathobiology, Temerty Faculty of Medicine, University of Toronto