Assistant Professor

Lei Fu

Department of Laboratory Medicine & Pathobiology - Clinical Chemistry


Sunnybrook Health Science Centre
2075 Bayview Ave., Clin Pathology, Rm B-204, Toronto, Ontario Canada M4N 3M5
Research Interests
Genetics Genomics & Proteomics, Metabolism & Nutrition
Appointment Status

Research Synopsis

  1. Pharmacogenomics and warfarin sensitivity: a study of clinical correlation and molecular mechanism
  2. Molecular relationships of serum vitamin D and its-binding protein with bone and mineral metabolism, diabetes, and cancer 
  3. Biomarkers in assessment of liver fibrosis – a non-invasive diagnostic approach potentially replacing liver biopsy
  4. Serum hyperglycosylated human chorionic gonadotropin as a biomarker for improved diagnosis and management of gestational trophoblastic disease
  5. Clinical studies in biochemistry and molecular diagnostics: quality management, methods development, methods evaluation, clinical utilizations, case investigations, etc.


Recent Publications


In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations.
Dastani Z, Berger C, Langsetmo L, Fu L, Wong BY, Malik S, Goltzman D, Cole DE, Richards JB. J Bone Miner Res. 2014 Feb;29(2):494-9. doi: 10.1002/jbmr.2042. PMID: 23857798

Common variants of the vitamin D binding protein gene and adverse health outcomes. Malik S, Fu L, Juras DJ, Karmali M, Wong BY, Gozdzik A, Cole DE. Crit Rev Clin Lab Sci. 2013 Jan-Feb;50(1):1-22. doi: 10.3109/10408363.2012.750262. Epub 2013 Feb 22. Review. PMID: 23427793

Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers.
Carpenter TO, Zhang JH, Parra E, Ellis BK, Simpson C, Lee WM, Balko J, Fu L, Wong BY, Cole DE. J Bone Miner Res. 2013 Jan;28(1):213-21. doi: 10.1002/jbmr.1735. PMID: 22887780

Evaluation of the warfarin-resistance polymorphism, VKORC1 Asp36Tyr, and its effect on dosage algorithms in a genetically heterogeneous anticoagulant clinic. Shuen AY, Wong BY, Fu L, Selby R, Cole DE.Clin Biochem. 2012 Apr;45(6):397-401. Epub 2012 Jan 13.PMID: 22266406

Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry.
Gozdzik A, Zhu J, Wong BY, Fu L, Cole DE, Parra EJ.
J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):405-12. Epub 2011 Jun 12. PMID: 21684333

The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation.
Wagner D, Hanwell HE, Schnabl K, Yazdanpanah M, Kimball S, Fu L, Sidhom G, Rousseau D, Cole DE, Vieth R.
J Steroid Biochem Mol Biol. 2011 Sep;126(3-5):72-7. doi: 10.1016/j.jsbmb.2011.05.003. Epub 2011 May 13. PMID: 21605672

Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE.
Clin Biochem. 2009 Jul;42(10-11):1174-7. Epub 2009 Mar 18.
PMID: 19302999

Frequency of CYP2C9 polymorphisms affecting warfarin metabolism in a large anticoagulant clinic cohort.
Moridani M, Fu L, Selby R, Yun F, Sukovic T, Wong B, Cole DE.
Clin Biochem. 2006 Jun;39(6):606-12. Epub 2006 Apr 21.
PMID: 16630605