Assistant Professor

Lianna Kyriakopoulou

Department of Laboratory Medicine & Pathobiology - Clinical Chemistry


Hospital for Sick Children (SickKids)
555 University Ave., Department of Paed Lab Med, Room S102 Elm Wing, Toronto, Ontario Canada M5G 1X8
Research Interests
Genetics Genomics & Proteomics, Molecular & Cell Biology
Clinical Interests
Clinical Chemistry
Appointment Status

Research Synopsis

My research focuses on genetic metabolic disorders. Currently,  the emphasis is on understanding the pathobiology of Congenital Disorders of Glycosylation as well as developing new methods for the diagnosis of this group of diseases.

Recent Publications

Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA, Pasic MD, Armbruster D and Adeli K. Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children. Clin Chem. 2012 Feb 27.

Long-term stability of biochemical markers in pediatric serum specimens stored at -80°C: A CALIPER Substudy. Brinc D, Chan MK, Venner AA, Pasic MD, Colantonio D, Kyriakopoulou L, Adeli K. Clin Biochem. 2012 Jul;45(10-11):816-26.  PMID: 22510430

Waye JS, Walker L, Kyriakopoulou LG, Potter MA and Eng B. Characterisation of a novel 49.3 kb Ggamma(Agamma delta beta)(0) -thalassaemia deletion in seven families of Asian descent. Br J Haematol. 2007 Jul;138(1):125-6.

Kyriakopoulou LG, Yousef GM, Scorilas A, Katsaros D, Massobrio M, Fracchioli S, Diamandis EP. Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer. Clinical Biochemistry. 2003 36 135-143.

Kyriakopoulou L G. Book Review of “Molecular testing in Laboratory Medicine-Selections from Clinical Chemistry”. Clinical Biochemistry. 2003 36 583.

Yousef GM, Scorilas A, Kyriakopoulou L, Rendel L, Diamandis M, Ponzone R, Biglia N, Giai M, Roagna R, Sismondi P, Diamandis EP. Human kallikrein Gene 5 (KLK5) expression by quantitative PCR: An independent indicator of poor prognosis in breast cancer. Clinical Chemistry. 2002, 48: 8 1241-1250.

Scorilas A, Kyriakopoulou L, Katsaros D, and Diamandis EP. Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive cancer. Br. J. Cancer. 2001 85(2) 190-198.

Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth L, Kwamie A, Diamandis EP. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. Genomics. 72:217-221, 2001.

Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S4, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D. Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker. Cancer Res. 2001, 61, 7811-7818.