Miralem Mrkonjic
MD, PhD, FRCPC, FCAP
Research Synopsis
My current research interests are in molecular biology of breast and gynaecologic malignancies, with a special focus in discovery, development and utilization of prognostic and predictive biomarkers that can be utilized for targeted therapy.
My other area of interest is in digital pathology and utilization of whole slide images by machine based learning to extract prognostic information not discerned by the conventional microscopy.
Selected Publications
Breast specimen handling and reporting in the post-neoadjuvant setting: challenges and advances. Mrkonjic M, Berman HK, Done SJ, Youngson B, Mulligan AM. J Clin Pathol. 2019 Feb;72(2):120-132. doi: 10.1136/jclinpath-2018-205598. Review.
The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer. Savio AJ, Mrkonjic M, Lemire M, Gallinger S, Knight JA, Bapat B. Clin Epigenetics. 2017 Mar 9;9:26. doi: 10.1186/s13148-017-0326-6. eCollection 2017.
MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals. Savio AJ, Lemire M, Mrkonjic M, Gallinger S, Zanke BW, Hudson TJ, Bapat B. PLoS One. 2012;7(12):e51531. doi: 10.1371/journal.pone.0051531. Epub 2012 Dec 11.
Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients. Rawson JB, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B. Br J Cancer. 2011 Jun 7;104(12):1906-12. doi: 10.1038/bjc.2011.165. Epub 2011 May 17.
Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. Rawson JB, Manno M, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B. Carcinogenesis. 2011 May;32(5):741-7. doi: 10.1093/carcin/bgr020. Epub 2011 Feb 8.