The Girardin lab studies the host innate immune responses to pathogenic microbes, using cellular and in vivo models of infection. A major focus of the lab is the intestinal epithelium, which serves as a fundamental interface between, on the one hand, enteric pathogens and the microbiota and, on the other hand, our immune defenses. Together, the ultimate goal of the team is to understand what drives intestinal inflammation, which can cause chronic diseases, such as Crohn’s disease and colorectal cancer.
Accepting MSc or PhD research students for 2021
After undergraduate studies at Ecole Normale Superieure d'Ulm/Paris VI University, Dr. Stephen Girardin studied JNK signal transduction pathways in the laboratory of Moshe Yaniv, at the Pasteur Institute (Paris, France) and obtained his PhD in 2001. Stephen next joined the laboratory of Philippe Sansonetti, also at the Pasteur Institute, to study the host responses to intracellular bacterial pathogens. His worked contributed to the characterization of the role of Nod-like receptors (NLRs) in innate immunity.
He obtained a faculty position at the Pasteur Institute in 2005 and was awarded an Inserm Avenir Junior Group Leader position in the same year. Stephen joined the Department of Laboratory Medicine and Pathobiology of the University of Toronto in 2006 and is now Professor within the LMP Department. Stephen is a recipient of a Burroughs Wellcome Fund (BWF) Award, Ontario Early Researcher Award, CIHR Young Investigator Award and former Canada Research Chair Tier 2 in Innate Immunity and Microbial Pathogenesis.
Stephen is currently the scientific director of the Microscopy Imaging Laboratory (MIL), the microscopy core facility of the Faculty of Medicine. He is also Vice-Chair, Research, for the LMP Department. Stephen is the Coordinator of LMP436H1 Microbial Pathogenesis 36L (detailed syllabus is available by clicking here) and co-coordinator of the LMP1001 course.