Cortisol assays list
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Cortisol assays are poorly standardized across different platforms and methods. A single cortisol cut-off for the ACTH Stimulation Test for adrenal deficiency often differs depending on the testing laboratory. Laboratories generally do not include thresholds for ACTH Stimulation Tests on their reports.
The list below provides the immunoassays used to assist Endocrinologists in the interpretation of cortisol levels where bias may exist between laboratories.
Please contact the laboratory’s biochemist for further information.
Key to Method Principle in table
- CMIA: Chemiluminescent Microparticle Immunoassay
- CLIA: Chemiluminescence Immunoassay
- ECLIA: Electrochemiluminescence Immunoassay
Manufacturer: Abbott
| Laboratory | Platform | Method | Biochemist contact |
|---|---|---|---|
| LifeLabs | Architect | CMIA | Dr. Uvaraj Uddayasankar |
| Sickkids | Architect | CMIA | Dr. Lusia Sepiashvili |
| CAMH | Alinity | CMIA | Dr. Cristiana Stefan |
| UHN | Alinity | CMIA | Dr. Vathany Kulasingam |
Manufacturer: Beckman
| Laboratory | Platform | Method | Biochemist contact |
|---|---|---|---|
| Scarborough | UniCel DxI | CLIA | Dr. Zahraa Mohammed-Ali |
| Mackenzie | UniCel DxI | CLIA | Maria De Oliveira |
Manufacturer: Roche
| Laboratory | Platform | Method | Biochemist contact |
|---|---|---|---|
| Dynacare | Elecsys | ECLIA | Dr. Hui Li |
| Humber River | Elecsys | ECLIA | Dr. Atoosa Rezvanpour |
| Markham Stouffville | Elecsys | ECLIA | Dr. Daniel Beriault |
| Michael Garron | Elecsys | ECLIA | Dr. Paul Yip |
| Mount Sinai | Elecsys | ECLIA | Dr. Felix Leung |
| North York | Elecsys | ECLIA | Dr. Paul Yip |
| Sunnybrook | Elecsys | ECLIA | Dr. Lei Fu |
| Women’s College | Elecsys | ECLIA | Dr. Felix Leung |
Manufacturer: Siemens
| Laboratory | Platform | Method | Biochemist contact |
|---|---|---|---|
| Lakeridge | Centaur XPT | CLIA | Dr. Rajeevan Selvaratnam |
| St. Michael’s | Centaur XP | CLIA | Dr. Daniel Beriault |
| St. Joseph’s | Centaur XP | CLIA | Dr. Daniel Beriault |
| Trillium | Centaur XP | CLIA | Dr. Kun-Young Sohn |
| William Osler | Atellica | CLIA | Dr. Saranya Arnoldo |
References
Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance.
Authors / contact
Compiled by
Associate Professor, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Science Centre and University of Toronto
Clinical lead
Dr. Julie Gilmour
Contributors
Khosrow Adeli, Saranya Arnoldo, Daniel Beriault, Lei Fu, Davor Brinc, Felix Leung, Hui Li, Zahraa Mohammed-Ali, Atoosa Rezvanpour, Lusia Sepiashvili, Kun-Young Sohn, Cristiana Stefan, Uvaraj Uddayasankar, Paul Yip
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