Assistant Professor

Ali Sakhdari

Department of Laboratory Medicine & Pathobiology - Hematological Pathology


Toronto General Hospital: University Health Network (UHN)
200 Elizabeth St., Lab Medicine Program, 11th Floor 11E-453, Toronto, Ontario Canada M5G 2C4
Research Interests
Clinical Interests
Pathology: Hematological
Appointment Status
Accepting medical students for shadowing

Dr Sakhdari received his medical degree from Mashhad University of Medical Sciences.

His post graduation studies included a master degree in Immunology from the University of Toronto, Anatomical and Clinical pathology specialties from the University of Massachusetts and Hematopathology subspecialty from MD Anderson Cancer Center/ University of Texas.

He is certified in Anatomical, Clinical and Hematological pathology from the American Board of Pathology. 

He is currently working as an assistant professor at the University Health Network as a hematopathologist.

Research Synopsis

My main interest is lymphoma. I am currently involved in several research projects related to follicular lymphoma and diffuse large B cell lymphoma.

The major focus of follicular lymphoma studies is on biological and molecular predictors of transformation of low-grade lymphomas to high-grade neoplasms.

In the diffuse large B cell lymphoma field, the main emphasis is on finding new prognostic and predictive factors beyond the cell of origin classification.

Selected Publications

A Sakhdari, Z Tang, CY Ok, CE Bueso-Ramos, LJ Medeiros, YO Huh; Homogeneously staining region (hsr) on chromosome 11 is highly specific for KMT2A amplification in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) Cancer genetics 238, 18-22

Ali Sakhdari, Parnian Ahmadi Moghaddam; Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool; Oncotarget

A Sakhdari; TP53 mutations are common in mantle cell lymphoma, including the indolent leukemic non-nodal variant; Ann Diagn Pathol.

A Sakhdari, LJ Medeiros; Update on Lymphoma classification: the 2016 revised World Health Organization Classification of Hematopoietic and Lymphoid Neoplasms; Advances in Cell and Gene Therapy

A Sakhdari, KH Young, R Miranda, LJ Medeiros, CY Ok; Enhancer of Zeste Homolog 2 (EZH2) Expression in Mantle Cell Lymphoma Correlates with Ki-67 Proliferation Rate, but Does Not Correlate with Trimethylation of Histone H3 at; Laboratory Investigation 99

A Sakhdari, K Lyapichev, LJ Medeiros, G Tang; Acute Myeloid Leukemia (AML) with Sole del (11q) Is Associated with Cytopenia, Dysplasia and a Poor Outcome; Laboratory Investigation 99

A Sakhdari, G Tang, LE Ginsberg, CF Hirsch-Ginsberg, CE Bueso-Ramos; Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy; Case reports in pathology 2019

A Sakhdari, S Loghavi, R Kanagal-Shamanna, CC Yin, Z Zuo, M Routbort; RAS and TP53, Not NOTCH1, Can Predict Survival in Adults with Acute T-Cell Lymphoblastic Leukemia Treated with Hypercvad; Blood 132 (Suppl 1), 4085-4085

EE Delaney, A Larkin, S MacMaster, A Sakhdari, CM DeBenedectis; Rosai-Dorfman Disease of the Breast; Cureus 9 (4)

A Sakhdari, L Hutchinson, N Vaskas, M Scott, EF Cosar, R Al-Turkmani; Routine Analysis of Lipase in Cyst Fluid Is Unnecessary and Does Not Help Discriminate Between Nonneoplastic and Neoplastic Cystic Pancreatic Lesions; Pancreas 46 (3), e25-e27

M Magotra, A Sakhdari, PJ Lee, K Tomaszewicz, K Dresser Immunohistochemical loss of 5‐hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways; Histopathology 69 (6), 1055-1065

A Sakhdari, PA Moghaddam, Y Liu; Endometrial samples from postmenopausal women: a proposal for adequacy criteria; International Journal of Gynecological Pathology 35 (6), 525-530

A Sakhdari, PA Moghaddam, Y Liu; Mutually exclusive extracellular signal‐regulated kinase pathway mutations are present in different stages of multi‐focal pulmonary Langerhans cell histiocytosis supporting; Histopathology 69 (3), 499-509

PA Moghaddam, R Virk, A Sakhdari, ML Prasad, EF Cosar, A Khan; Five top stories in thyroid pathology; Archives of pathology & laboratory medicine 140 (2), 158-170

A Sakhdari, S Mujib, B Vali, FY Yue, S MacParland, K Clayton, RB Jones; Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection; PloS one 7 (7), e40146